Chronic kidney disease epidemic: How do we deal with it?

Ng, Jack Kit-Chung; Li, Philip Kt

doi:10.1111/nep.13464

Cited by 76 publications

(61 citation statements)

References 40 publications

(78 reference statements)

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“…Increasing prevalence of chronic kidney disease (CKD), high costs of treating individuals with kidney failure, and poor outcomes related to renal replacement therapies are important health challenges across the globe [1]. It has been suggested, that the overall burden of CKD is largely driven by the increase in the prevalence of diabetes, mainly that of type 2 https://doi.org/10.1016/j.diabres.2019.06.016 0168-8227/Ó 2019 Published by Elsevier B.V. [2]. However CKD is a major health concern also in type 1 diabetes (T1D) as, over the course of a lifetime, diabetic nephropathy affects approximately one third of this population [3].…”

Section: Introductionmentioning

confidence: 99%

Dietary intake in type 1 diabetes at different stages of diabetic kidney disease

Ahola

Forsblom

Groop

2019

Diabetes Research and Clinical Practice

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Diet plays an important role in the kidney health of individuals with type 1 diabetes. However, not much is known about dietary practices at different stages of diabetic nephropathy. We aimed at investigating food intake, dietary patterns, and nutrient intakes in individuals with type 1 diabetes differing in renal status. Methods: Data were available from 1874 individuals with type 1 diabetes (45% men, age 48 ± 13 years). Diet was assessed at the levels of food items and diet patterns (diet questionnaire), and energy and nutrient intakes (food record). Six groups were formed based on the eGFR or dialysis and transplantation status. Results: Reductions in liquid-milk product and salt consumption, and increase in special diet adherence were observed at the early stages of eGFR decline. Reduced coffee consumption was observed after eGFR was <30 ml/min/1.73 m 2. With advancing kidney failure, rye bread consumption decreased, but that of wheat bread increased. Compared to those with intact kidney function (the index group), the Fish and vegetable diet pattern scores were higher in individuals with mildly-to-severely decreased eGFR. Instead, the Sweet pattern scores were lower than in the index group in all other groups. Energy intake was lower in all groups compared to those with intact kidney function. Advancing kidney failure was associated with reductions in protein intake per body weight, and in the intakes of sodium, potassium, calcium, and phosphorus. Conclusions: Differences in the dietary intake are seen already at the early stages of kidney function decline.

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Section: Introductionmentioning

confidence: 99%

Dietary intake in type 1 diabetes at different stages of diabetic kidney disease

Ahola

Forsblom

Groop

2019

Diabetes Research and Clinical Practice

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“…The prevalence of chronic kidney disease (CKD) has risen significantly during the last several decades, and it is now a major public health issue that poses enormous economic challenges worldwide (1). According to recent epidemiological surveys, more than 500 million people worldwide currently have some stage of CKD (2,3).…”

Section: Introductionmentioning

confidence: 99%

Advances in Understanding the Effects of Erythropoietin on Renal Fibrosis

et al. 2020

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Renal fibrosis is the common manifestation of the pathogenesis of end-stage renal disease that results from different types of renal insult, and is a hallmark of chronic kidney disease (CKD). The main pathologic characteristics of renal fibrosis are renal interstitial fibroblast hyperplasia and the aberrant and excessive deposition of extracellular matrix, pathologies that lead to the destruction of normal renal tubules and interstitial structures. However, the biological significance of fibrosis during the progression of CKD is not clear, and there are no approved clinical treatments for delaying or reversing renal fibrosis. Studies of the mechanism of renal fibrosis and of potential measures of prevention and treatment have focused on erythropoietin (EPO), a hormone best known as a regulator of red blood cell production. These recent studies have found that EPO may also provide efficient protection against renal fibrosis. Future therapeutic approaches using EPO offer new hope for patients with CKD. The aim of the present review is to briefly discuss the role of EPO in renal fibrosis, to identify its possible mechanisms in preventing renal fibrosis, and to provide novel ideas for the use of EPO in future treatments of renal fibrosis.

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“…Delaying the development of CKD is critical. Studies have found that using RAS inhibitors and controlling salt levels, blood pressure, and blood lipid levels can effectively delay the development of CKD, providing the direction for the development of speci c therapeutic drugs [1,6]. In recent years, the replacement therapy of CKD brosis by natural products has attracted the attention of many scholars [7].…”

Section: Introductionmentioning

confidence: 99%

Extract of Corallodiscus Flabellata Attenuates Renal Fibrosis in Aging Mice via the Wnt/β-catenin/RAS Signaling Pathway

Cao

Zeng

et al. 2020

Preprint

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Abstract Background: Renal fibrosis is a common pathological feature of chronic kidney disease (CKD). Aging accelerates renal fibrosis and further aggravates the process of CKD. Corallodiscus flabellata B. L. Burtt (C. flabellata) is a commonly used botanical drug in the Chinese population. However, few studies have reported its physiological effects. This study aimed to explore the effect of C. flabellata extract on renal fibrosis in aging mice and identify potentially active compounds. Methods: Using Senescence-accelerated mouse-prone 8 (SAMP8) mice and β-galactosidase (β-gal)-induced normal rat kidney epithelial cells (NRK-52E cells) as a model, to explore the mechanism of C. flabellata extract on senescence-related renal fibrosis, and initially clarified the material basis of C. flabellata. Results: The C. flabellata extract reduced the senescence and fibrosis of the kidneys in SAMP8 mice by activating nuclear factor erythroid 2–related factor 2 (Nrf2) to balance oxidative stress and inflammation, and interrupting the fibrinogen signaling in the Wnt/β-catenin/renin–angiotensin system. Moreover, 3,4-dihydroxyphenylethanol (SDC-0-14, 16) and (3,4-dihydroxyphenylethanol-8-O-[4-O-trans-caffeoyl-β-D-apiofuranosyl-(1→3)-β-D-glucopyranosyl (1→6)]-β-D-glucopyranoside (SDC-1-8) were isolated compounds from C. flabellata, which reduced the senescence of NRK-52E cells, and maybe the material basis for the function of C. flabellata. Conclusion: Our experiments illuminated that the extract of C. flabellata may improve the aging-related renal fibrosis through the Wnt/β-catenin/RAS pathway, and the material basis of its function may be SDC-0-14, 16 and SDC-1- 8.

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Chronic kidney disease epidemic: How do we deal with it?

Cited by 76 publications

References 40 publications

Dietary intake in type 1 diabetes at different stages of diabetic kidney disease

Dietary intake in type 1 diabetes at different stages of diabetic kidney disease

Advances in Understanding the Effects of Erythropoietin on Renal Fibrosis

Extract of Corallodiscus Flabellata Attenuates Renal Fibrosis in Aging Mice via the Wnt/β-catenin/RAS Signaling Pathway

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