Chronic hepatitis C and liver fibrosis

Sebastiani, Giada; Gkouvatsos, Konstantinos; Pantopoulos, Kostas

doi:10.3748/wjg.v20.i32.11033

Cited by 200 publications

(142 citation statements)

References 199 publications

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“…Zubia Jamil 1 The predictive value of various noninvasive markers have been extensively studied in last two and more decades in detecting esophageal varices (2,3,7,8). These markers are emphasized to a large extend as they are simple, noninvasive, easy to obtain and interpret, and economical, with some markers having good accuracy in predicting esophageal varices.…”

Section: Platelet Count To Splenic Diameter Ratio and Other Noninvasimentioning

confidence: 99%

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Platelet count to splenic diameter ratio and other noninvasive markers as predictors of esophageal varices in patients with liver cirrhosis

Jamil

Malik²,

Durrani³

2017

Turk J Gastroenterol

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Background/Aims: Endoscopy as a screening modality for esophageal varices is becoming difficult because of its invasiveness, cost, and increased burden of liver cirrhosis. This study aims to determine the diagnostic accuracy of simple and noninvasive markers in detecting esophageal varices. Materials and Methods: Four variables (platelet count, portal vein diameter, splenic diameter, and ratio of platelet count to splenic diameter PC/SD] ratio) were studied in 150 cirrhotic patients. Endoscopy was performed to detect esophageal varices in the patients. The diagnostic accuracy of these variables was determined by obtaining area under the receiver operating characteristic (ROC) curve (AUC). The cutoff value of each variable and its sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios were obtained using the Youden index. Pairwise comparison of these variables was performed using the Hanley and McNeil method to determine the most reliable screening tool among them. Results: The PC/SD ratio was the most reliable indicator for the presence of varices: AUC=0.9 (p<0.0001; cutoff value, ≤1077.42; sensitivity, 88.75%; specificity, 81.43%). The AUC for platelets and splenic diameter was 0.85 (p<0.0001) and 0.77 (p<0.0001), respectively, showing they were also good indicators. The portal vein diameter was not a good predictor for esophageal varices (AUC=0.59). Pairwise comparison of these variables showed that the PC/SD ratio is statistically significant for predicting esophageal varices among these markers (p<0.05). Conclusion: The PC/SD ratio is found to be the most reliable marker to prognosticate esophageal varices. It is easy to obtain and can be used with other markers to identify the high-risk patients for developing esophageal varices. It will definitely reduce the need for endoscopy as screening purposes and lower the medical expenditures.

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Section: Platelet Count To Splenic Diameter Ratio and Other Noninvasimentioning

confidence: 99%

“…Liver cirrhosis is characterized by extensive fibrosis not only involving hepatic parenchyma but also the portal tract leading to the well-known complication of portal hypertension (1). Portal hypertension is interpreted by finding portal vein and hepatic vein pressure gradient exceeding 10-12 mmHg (2).…”

Section: Introductionmentioning

confidence: 99%

Platelet count to splenic diameter ratio and other noninvasive markers as predictors of esophageal varices in patients with liver cirrhosis

Jamil

Malik²,

Durrani³

2017

Turk J Gastroenterol

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“…Chronic infection with HCV is a leading cause of liver related morbidity and mortality worldwide and predisposes to liver fibrosis and end-stage liver complications [10] (Tables 1-4 and Figures 1-4). …”

Section: Resultsmentioning

confidence: 99%

Serum Osteopontin and Cytokeratin-18 in Chronic Hepatitis C Patients

El-Saeed¹,

Abo-Raia²,

Noreldin³

et al. 2017

Adv Tech Biol Med

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“…In allusion to semantic [1][2] treatment of heterogeneous data, certain research achievements have been gained correctly. Xu J.…”

Section: Related Researchesmentioning

confidence: 99%

Study on Ontology-based Semantic Extraction Method for Heterogeneous Data

Li¹,

Zhang²,

Yang³

et al. 2015

Proceedings of the First International Conference on Information Sciences, Machinery, Materials and Energy

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Abstract. In allusion to scientific data isomerism and diversity as well as the lack of semantics in petroleum domain, this paper puts forward ontology-based semantic extraction method for heterogeneous data. Firstly, semantic extraction framework for scientific data in petroleum domain is constructed. On this basis, corresponding semantic transformation and abstract rules are worked out in allusion to structured and semi-structured data to form local domain ontology. Then, overall ontology in petroleum domain of data is constructed through dependence mapping among heterogeneous data. Effective organization and uniform management of heterogeneous data are achieved. Finally, correlation methods are applied in petroleum domain to provide support for effective management of petroleum scientific data and service sharing.

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Chronic hepatitis C and liver fibrosis

Cited by 200 publications

References 199 publications

Platelet count to splenic diameter ratio and other noninvasive markers as predictors of esophageal varices in patients with liver cirrhosis

Platelet count to splenic diameter ratio and other noninvasive markers as predictors of esophageal varices in patients with liver cirrhosis

Serum Osteopontin and Cytokeratin-18 in Chronic Hepatitis C Patients

Study on Ontology-based Semantic Extraction Method for Heterogeneous Data

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