Chronic heat stress up-regulates leptin and adiponectin secretion and expression and improves leptin, adiponectin and insulin sensitivity in mice

Morera, P.; Basiricò, Loredana; Hosoda, Kei; Bernabucci, U.

doi:10.1530/jme-11-0054

Cited by 89 publications

(72 citation statements)

References 38 publications

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“…In fact, results suggested that heat stress may not directly affect the expression Table 3 (P<0.05). The up-regulation of adiponectin observed in this study agrees with previous findings in mice and 3T3-L1 adipocytes (Bernabucci et al, 2009;Morera et al, 2012), confirming a role of heat stress in modulating adiponectin expression. Park et al (2005) pointed out that heat stress induced an increase in the fluidity of membrane lipids, may cause signal transduction that would induce the cellular heat shock response to increase the HSP expression, which could directly stimulate adiponectin expression.…”

Section: Resultssupporting

confidence: 92%

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Effects of heat stress on serum insulin, adipokines, AMP-activated protein kinase, and heat shock signal molecules in dairy cows

Cheng

Shi

et al. 2015

J. Zhejiang Univ. Sci. B

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Heat stress affects feed intake, milk production, and endocrine status in dairy cows. The temperaturehumidity index (THI) is employed as an index to evaluate the degree of heat stress in dairy cows. However, it is difficult to ascertain whether THI is the most appropriate measurement of heat stress in dairy cows. This experiment was conducted to investigate the effects of heat stress on serum insulin, adipokines (leptin and adiponectin), AMP-activated protein kinase (AMPK), and heat shock signal molecules (heat shock transcription factor (HSF) and heat shock proteins (HSP)) in dairy cows and to research biomarkers to be used for better understanding the meaning of THI as a bioclimatic index. To achieve these objectives, two experiments were performed. The first experiment: eighteen lactating Holstein dairy cows were used. The treatments were: heat stress (HS, THI average=81.7, n=9) and cooling (CL, THI average=53.4, n=9). Samples of HS were obtained on August 16, 2013, and samples of CL were collected on April 7, 2014 in natural conditions. The second experiment: HS treatment cows (n=9) from the first experiment were fed for 8 weeks from August 16, 2013 to October 12, 2013. Samples for moderate heat stress, mild heat stress, and no heat stress were obtained, respectively, according to the physical alterations of the THI. Results showed that heat stress significantly increased the serum adiponectin, AMPK, HSF, HSP27, HSP70, and HSP90 (P<0.05). Adiponectin is strongly associated with AMPK. The increases of adiponectin and AMPK may be one of the mechanisms to maintain homeostasis in heat-stressed dairy cows. When heat stress treatment lasted 8 weeks, a higher expression of HSF and HSP70 was observed under moderate heat stress. Serum HSF and HSP70 are sensitive and accurate in heat stress and they could be potential indicators of animal response to heat stress. We recommend serum HSF and HSP70 as meaningful biomarkers to supplement the THI and evaluate moderate heat stress in dairy cows in the future.

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Section: Resultssupporting

confidence: 92%

“…Heat stress up-regulates leptin expression and secretion in mice and 3T3-L1 adipocytes (Bernabucci et al, 2009;Morera et al, 2012). Very little work has been done to evaluate changes and the biological role of leptin in heat-stressed dairy cows.…”

Section: Resultsmentioning

confidence: 99%

Effects of heat stress on serum insulin, adipokines, AMP-activated protein kinase, and heat shock signal molecules in dairy cows

Cheng

Shi

et al. 2015

J. Zhejiang Univ. Sci. B

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“…Mice subjected to 8 C for 12 h had decreases in leptin concentrations. 39 Additionally, mouse preadipocytes exposed to 39 C and 41 C produced incremental increases in leptin when compared with cells exposed to 37 C. 43 Similar to leptin in a mouse model, mice that were exposed to chronic heat stress showed elevated adiponectin concentrations, 38 whereas, during a 24 h exposure to 4 C adiponectin levels were decreased. 37 It is difficult to interpret the effect on appetite when an appetite-reducing hormone (leptin) and an appetite-stimulating hormone (adiponectin) are increased or decreased together.…”

Section: Discussionmentioning

confidence: 94%

“…15,16,36 However, in a mouse model, heat exposure generally increased leptin and adiponectin concentration while cold exposure decreased leptin and adiponectin concentration. [37][38][39][40] Temperature and exercise both appear to independently affect leptin, adiponectin, and ghrelin. The potential impact of exercising in different environmental temperatures on appetite-regulating hormones is unknown.…”

Section: Introductionmentioning

confidence: 99%

Leptin, adiponectin, and ghrelin responses to endurance exercise in different ambient conditions

et al. 2017

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Excessive positive energy balance is a major factor leading to obesity. The ability to alter the appetite-regulating hormones leptin, adiponectin, and ghrelin may help decrease excessive energy intake. Exercise and exposure to extreme temperatures can independently affect these appetiteregulating hormones. PURPOSE: To determine the effect of exercising in different environmental conditions on the circulating concentrations of leptin, adiponectin, and ghrelin. METHODS: Eleven recreationally-trained male participants completed 3 separate 1 h cycling bouts at 60% W max in hot, cold, and room temperature conditions (33 C, 7 C, 20 C), followed by a 3 h recovery at room temperature. Blood was drawn pre-exercise, post-exercise, and 3 h post-exercise. Hematocrit and hemoglobin were measured to account for change in plasma volume. RESULTS: Leptin concentrations were lower at post and 3 h post-exercise compared with pre-exercise, with and without correction for plasma volume shifts, regardless of temperature (p < 0.05). Adiponectin was higher post-exercise compared with pre-exercise (p D 0.021) but not 3 h post-exercise (p D 0.084) without correction for plasma volume shifts. However, adiponectin concentrations were not different at any time point when plasma volume shifts were accounted for (p > 0.05). Total ghrelin and acylated ghrelin concentrations were not affected at post and 3 h post-exercise compared with pre-exercise, with and without correcting for plasma volume shifts, regardless of ambient temperature (p > 0.05). No differences in leptin, adiponectin, or ghrelin were found between trials (p > 0.05). CONCLUSION: Temperature does not affect the circulating concentrations of appetiteregulating hormones during an acute bout of endurance exercise.

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“…In chronically heat-stressed mice, adipose tissue leptin mRNA expression was significantly increased, which was paralleled by an increase in circulating plasma leptin despite the concurrent decrease in feed intake; perhaps indicating that heat treatment itself influences leptin (Morera et al 2012).…”

Section: Leptin and Thermogenesismentioning

confidence: 97%

Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review

DiGiacomo¹,

Leury²,

Dunshea³

2014

Anim. Prod. Sci.

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Abstract. Environmental conditions influence animal production from an animal performance perspective and at the carcass level post-slaughter. High rigor temperature occurs when the animal is hyperthermic pre-slaughter, and this leads to tougher meat. Hyperthermia can result from increased environmental temperature, exercise, stress or a combination of these factors. Consumer satisfaction with beef meat is influenced by the visual and sensory traits of the product when raw and cooked, with beef consumers commonly selecting tenderness of the product as the most important quality trait. High rigor temperature leads to a reduction in carcass and eating quality. This review examines some possible metabolic causes of hyperthermia, with focus on the importance of adipose tissue metabolism and the roles of insulin and leptin. Potential strategies for the amelioration or prevention of high rigor temperature are offered, including the use of dietary supplements such as betaine and chromium, anti-diabetic agents such as thiazolidinediones, vitamin D, and magnesium (Mg) to provide stress relief.

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Chronic heat stress up-regulates leptin and adiponectin secretion and expression and improves leptin, adiponectin and insulin sensitivity in mice

Cited by 89 publications

References 38 publications

Effects of heat stress on serum insulin, adipokines, AMP-activated protein kinase, and heat shock signal molecules in dairy cows

Effects of heat stress on serum insulin, adipokines, AMP-activated protein kinase, and heat shock signal molecules in dairy cows

Leptin, adiponectin, and ghrelin responses to endurance exercise in different ambient conditions

Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review

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