Chronic heart failure and aging – effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study

Sandri, Monica; Viehmann, Manuel; Adams, Volker; Rabald, Kristin; Mangner, Norman; Höllriegel, Robert; Lurz, Philipp; Erbs, Sandra; Linke, Axel; Kirsch, Katharina; Möbius‐Winkler, Sven; Thiery, Joachim; Teupser, Daniel; Hambrecht, Rainer; Schuler, Gerhard; Gielen, Stephan

doi:10.1177/2047487315588391

Cited by 86 publications

(121 citation statements)

References 52 publications

(69 reference statements)

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“…Lastly, we only studied sedentary people with no recent history of exercise training. Aerobic exercise training increases EPC number in people with cardiovascular diseases (21,27,30), but further research is needed to determine whether exercise training can restore EPC mobilization in older adults with IGT or T2DM.…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes

et al. 2016

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Lutz AH, Blumenthal JB, Landers-Ramos RQ, Prior SJ. Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes. J Appl Physiol 121: 36 -41, 2016. First published May 19, 2016 doi:10.1152/japplphysiol.00349.2016.-Circulating endothelial progenitor cells (EPCs) contribute to vascular homeostasis and are fewer in those with type 2 diabetes mellitus (T2DM) compared with normal glucose tolerance (NGT), suggesting a link between EPCs and T2DM-associated vasculopathies. The purpose of this study was to assess EPC number and mobilization by acute submaximal exercise in older adults with NGT, impaired glucose tolerance (IGT) or T2DM. We tested the hypothesis that EPC mobilization is lower in IGT compared with NGT and further reduced in older adults with T2DM. Forty-five older (50-75 yr of age) men and women with NGT (n ϭ 18), IGT (n ϭ 10), or T2DM (n ϭ 17) were characterized and underwent submaximal aerobic exercise tests with blood sampling for enumeration of vascular endothelial growth factor receptor 2ϩ (VEGFR2ϩ) cells, CD34ϩ hematopoetic progenitor cells, and CD34ϩ/VEGFR2ϩ EPCs by flow cytometry before and after exercise. Basal EPC number was 65 and 61% lower in the IGT and T2DM groups, respectively, compared with the NGT group (P Ͻ 0.05). EPC number increased 23% after acute exercise in the NGT group (P Ͻ 0.01), but did not change in the IGT or T2DM groups. Before and after exercise, VEGFR2ϩ cell number was lower in a stepwise manner across the NGT, IGT, and T2DM groups (P Ͻ 0.05). Basal CD34ϩ cell number was lower in the IGT group compared with NGT (P Ͻ 0.05), but did not change after exercise in any group. These findings suggest a CD34ϩ/VEGFR2ϩ EPC mobilization defect in IGT and T2DM that could play a role in the cardiovascular diseases and capillary rarefaction associated with insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes

et al. 2016

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“…A recent study (Sandri et al, 2015) has examined whether CHF and aging exert synergistic effects on EPCs, thus counteracting the beneficial effects of ET in old age. After 4 weeks of ET, EPC number and function improved significantly, both in subjects less than 55 year old and in those older than 65 years.…”

Section: Effect Of Exercise On Endothelial Repair Mechanisms In Chfmentioning

confidence: 99%

“…Although pharmacological treatment has considerably improved its prognosis, the life expectancy these patients is limited. CHF prevalence increases with age in both men and women (Sandri et al, 2015 andGo et al, 2014). Given the increased life expectancy of the general population in developed countries, there is a need to identify the mechanisms involved in CHF development and new druggable targets (Williamson et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Physical activity and progenitor cell-mediated endothelial repair in chronic heart failure: Is there a role for epigenetics?

Recchioni

Marcheselli

Antonicelli

et al. 2016

Mechanisms of Ageing and Development

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“…Forty-one patients who fulfilled all the inclusion criteria were enrolled in the study: NoSDB (n=13, 46 [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] years) and SDB (n=28, 57 [54-61] years). In the SDB group, 6 patients had CSA, and 22 had OSA.…”

Section: Baseline Measuresmentioning

confidence: 99%

“…47 Moreover, other studies show that amelioration in SDB contributes to better clinical outcome in patients with chronic HF. For example, exercise training improves sleep pattern in HF patients with SDB 27 and, in addition, improves endothelial function 48 and remarkably reduces MSNA in chronic HF patients with CSA and OSA. 27,49,50 Similar findings have been reported with continuous positive airway pressure.…”

Section: Perspectivesmentioning

confidence: 99%

Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure

Lobo

Trevizan

Toschi‐Dias

et al. 2016

Circ: Heart Failure

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Background— Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and hypoxia and hypercapnia episodes activate chemoreceptors stimulating autonomic reflex responses. We tested the hypothesis that muscle vasoconstriction and muscle sympathetic nerve activity (MSNA) in response to hypoxia and hypercapnia would be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD). Methods and Results— Ninety consecutive patients with HF, New York Heart Association functional class II–III, and left ventricular ejection fraction ≤40% were screened for the study. Forty-one patients were enrolled: NoSDB (n=13, 46 [39–53] years) and SDB (n=28, 57 [54–61] years). SDB was characterized by apnea–hypopnea index ≥15 events per hour (polysomnography). Peripheral (10% O 2 and 90% N 2 , with CO 2 titrated) and central (7% CO 2 and 93% O 2 ) chemoreceptors were stimulated for 3 minutes. Forearm and calf blood flow were evaluated by venous occlusion plethysmography, MSNA by microneurography, and blood pressure by beat-to-beat noninvasive technique. Baseline forearm blood flow, forearm vascular conductance, calf blood flow, and calf vascular conductance were similar between groups. MSNA was higher in the SDB group. During hypoxia, the vascular responses (forearm blood flow, forearm vascular conductance, calf blood flow, and calf vascular conductance) were significantly lower in the SDB group compared with the NoSDB group ( P <0.01 to all comparisons). Similarly, during hypercapnia, the vascular responses (forearm blood flow, forearm vascular conductance, calf blood flow, and calf vascular conductance) were significantly lower in the SDB group compared with the NoSDB group ( P <0.001 to all comparisons). MSNA were higher in response to hypoxia ( P =0.024) and tended to be higher to hypercapnia ( P =0.066) in the SDB group. Conclusions— Patients with HF and SDB have more severe muscle vasoconstriction during hypoxia and hypercapnia than HF patients without SDB, which seems to be associated with endothelial dysfunction and, in part, increased MSNA response.

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Chronic heart failure and aging – effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study

Abstract: Four weeks of exercise training are effective in improving EPC number and EPC function in CHF patients. These training effects were not impaired among older patients, emphasizing the potentials of rehabilitation interventions in a patient group where CHF has a high prevalence.

Cited by 86 publications

References 52 publications

Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes

Exercise-induced endothelial progenitor cell mobilization is attenuated in impaired glucose tolerance and type 2 diabetes

Physical activity and progenitor cell-mediated endothelial repair in chronic heart failure: Is there a role for epigenetics?

Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure

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