Chronic granulomatous disease: a review of the infectious and inflammatory complications

Song, Eun-Kyung; Jaishankar, Gayatri Bala; Saleh, Hanaa; Jithpratuck, Warit; Sahni, Ryan; Krishnaswamy, Guha

doi:10.1186/1476-7961-9-10

Cited by 152 publications

(151 citation statements)

References 162 publications

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“…Infections due to MRSA are a special concern in immunevulnerable populations, including hemodialysis (22), neutropenic (23,24), transplantation (25), and otherwise immunosuppressed patients (26,27), and in patients with inherited immune dysfunctions (28)(29)(30)(31) or cystic fibrosis (32). Patients having deficient interleukin 17 (IL-17) or IL-22 responses (e.g., signal transduction mediators STAT3, DOCK8, or CARD9 deficiencies) exhibit chronic or "cold" abscesses, despite high densities of pathogens such as S. aureus (33,34).…”

mentioning

confidence: 99%

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Yeaman

Filler

Chaili

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Staphylococcus aureus is an opportunistic pathogen of the normal human flora. It is among the most frequent causes of cutaneous abscesses, leading to life-threatening invasive infection. Incomplete understanding of host defenses against S. aureus skin or invasive infection has hindered development of effective vaccines to address these issues. NDV-3 is a unique cross-kingdom vaccine targeting S. aureus and Candida albicans . The present studies offer important new evidence: ( i ) NDV-3 protects against methicillin-resistant S. aureus skin and skin structure infection largely through IL-22– and IL-17A–mediated host defense peptide and neutrophil induction, ( ii ) vaccine-mediated IL-22 and IL-17A play distinct roles in protection against cutaneous versus invasive infection, and ( iii ) NDV-3 vaccine efficacy in this model involves a coordinated induction of innate and adaptive immunity.

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mentioning

confidence: 99%

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Yeaman

Filler

Chaili

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…It has been reported in the literature that a history of infection may not be present until early adult period and these patients have been accepted as mild forms of CGD according to mutation type [2]. This case had also suffered frequent pulmonary infections in recent years and applied to our clinic due to skin abscess.…”

Section: Discussionmentioning

confidence: 98%

“…The disease manifests itself with serious bacterial and fungal infections recurring since childhood [2]. The most frequently affected organ in CGD is the lungs.…”

Section: Introductionmentioning

confidence: 99%

Two Chronic Granulomatous Disease Diagnosed in Adult Age

Akyıl

Sevim

Barış

et al. 2016

Turk Toraks Dergisi

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Chronic granulomatous disease (CGD) is a rare, inherited primary immunodeficiency that is usually diagnosed at adulthood and is presented with recurrent bacterial and fungal infections. In this case report, two adult cases of CGD have been presented. A 29-yearold woman was referred to our clinic with hypoxic respiratory failure, with a pre-diagnosis of multidrug resistant tuberculosis (TB). Her lung biopsy had been reported as granulomatous inflammation, she hadnot responded to a 5 month anti-TB treatment. A complete medical history consisted of 4 occasions of treatment with anti-TB drugs and that her sister and brother had undergone TB therapy. However, since childhood, a TB bacilli had never been isolated microbiologically in the siblings. Patient's parents were third degree consanguineous. The patient still had a purulent drainage around the operation site. Microbiological studies of the wound drainage and respiratory tract have not encountered any specific microorganism. Investigation of an immunodeficiency has proved CGD through nitroblue tetrazolium test. Her siblings has been diagnosed as CGD as well.Second case, a 19-year-old male, has been admitted to our clinic with complaints of fever, chest pain and an abscess lesion in the anterior chest wall. His medical history comprised 3 recurrences of pneumonia within last 2 years. In physical examination, a 3 x 5 cm fluctuant swelling lesion on the anterior chest wall. Radiologically, new pneumonic consolidations were detected. Sputum specimens did not provide any specific microorganism, cultures of the chest-wall abscess fluid grew aspergillus. His parents had been living in the same village but no consanguinity was known. Due to recurrent infections, immunodeficiency tests had been investigated. He was diagnosed as CGD due to dihydrorhodamin test. These two cases signify that, in our country where consanguinity is common, etiology of recurrent unexplained infections, abscesses and granulomas should be investigated and CGD should be in differantial diagnosis list.

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“…The treatment for the disease is designed to help the immune system through antibacterial, antifungal and immunomodulatory therapy. Stem cell transplants and gene therapy are both definitive treatments used as the first clinical interventions [34].…”

Section: The "Good Side" Of Rosmentioning

confidence: 99%

Reactive Oxygen Species: The Good and the Bad

Patel¹,

Rinker²,

Peng³

et al. 2018

Reactive Oxygen Species (ROS) in Living Cells

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This chapter summarizes recent research on the biology of reactive oxygen species (ROS). The chapter is focused on the bimodal actions of ROS, which can be summarized as both beneficial and negative. The beneficial aspects of ROS are related to their effects on the redox state of cells and the important role that some ROS play in signaling cascade. The detrimental effects of ROS are related excess amounts of these chemical moieties, which are caused by excessive production and/or insufficient actions of endogenous antioxidants. The generation of these species is also discussed.

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Chronic granulomatous disease: a review of the infectious and inflammatory complications

Cited by 152 publications

References 162 publications

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection

Two Chronic Granulomatous Disease Diagnosed in Adult Age

Reactive Oxygen Species: The Good and the Bad

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