Chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy: a preliminary analysis

Mundt, Arno J.; Mell, Loren K.; Bonta, Dacian; Lujan, Anthony E.; Roeske, John C.

doi:10.1016/s0360-3016(02)03172-3

Cited by 49 publications

(60 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We [1,2] have demonstrated that IMRT planning significantly reduces the volume of small bowel, bladder and rectum irradiated in gynecology patients undergoing whole pelvic radiation therapy (WPRT). Moreover, we have observed significant reductions in both acute [3,4] and chronic [5] gastrointestinal (GI) sequelae in these women.…”

Section: Introductionmentioning

confidence: 96%

Incorporation of magnetic resonance imaging into intensity modulated whole-pelvic radiation therapy treatment planning to reduce the volume of pelvic bone marrow irradiated

Roeske

Mundt

2004

International Congress Series

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 96%

Incorporation of magnetic resonance imaging into intensity modulated whole-pelvic radiation therapy treatment planning to reduce the volume of pelvic bone marrow irradiated

Roeske

Mundt

2004

International Congress Series

View full text Add to dashboard Cite

“…Compared to a well-balanced cohort of conventional patients, IMRT was associated with less chronic gastrointestinal sequelae (11.1% vs 50%; P = 0.001). On multivariate analysis controlling for age, stage, chemotherapy, surgery, brachytherapy, and length of follow-up, IMRT remained correlated with less chronic gastrointestinal toxicity (P = 0.01; odds ratio 0.16; 95% confidence interval, 0.04-0.67) [42].…”

Section: Chronic Toxicitymentioning

confidence: 95%

“…• Mundt et al [42] evaluated chronic gastrointestinal toxicity in a cohort of 30 patients treated with intensity-modulated pelvic radiotherapy. Patients had a median follow-up time of 19.6 months (range 8-33 months).…”

Section: Chronic Toxicitymentioning

confidence: 99%

Intensity-modulated radiation therapy in gynecologic malignancies

Salama¹,

Roeske²,

Mehta³

et al. 2004

Curr. Treat. Options in Oncol.

View full text Add to dashboard Cite

Radiation therapy occupies an important role in the treatment of gynecologic malignancies. Unfortunately, traditional approaches result in the irradiation of large volumes of normal tissues exposing patients to many toxicities and precluding dose escalation in select patients. A novel approach to the planning and delivery of radiation therapy, known as intensity-modulated radiation therapy (IMRT), has been introduced. Unlike conventional approaches, IMRT conforms the prescription dose to the shape of the target in three dimensions, thus sparing the surrounding normal tissues. Multiple studies have demonstrated the clear superiority of IMRT planning in these patients in terms of normal tissue sparing. Promising clinical results have also been published, suggesting that IMRT reduces the incidence of acute and chronic toxicity in these women. Ongoing studies are focusing on tumor control and patient outcome. Although further work is needed, these results suggest that IMRT may represent a major advancement in the planning and delivery of radiation therapy in patients with gynecologic malignancies.

show abstract

“…Urbano and colleagues found a 26% reduction in bowel volume receiving greater than 45 Gy using IMRT rather than 3D-CRT [63]. Mundt et al found a 30-40% reduction in acute and late GI toxicity, respectively, in patients with gynaecological malignancy treated with IMRT rather than conventional whole-pelvis radiotherapy [64].…”

Section: Treatment and Preventionmentioning

confidence: 99%

Gastrointestinal toxicity associated to radiation therapy

et al. 2010

View full text Add to dashboard Cite

Radiation therapy in combination with other treatments, such as surgery and chemotherapy, increases locoregional control and survival in patients with thoracic, abdominal and pelvic malignancies. Nevertheless, significant clinical toxicity with combined treatments may be seen in these patients. With the advent of tridimensional conformal radiotherapy (3D-CRT), dose-volume histograms (DVH) can be generated to assess the dose received by the organs at risk. The possible relationship between these parameters and clinical, anatomical and, more recently, genetic factors has to be considered. Treatment options include initial conservative medical therapies, endoscopic procedures, hyperbaric oxygen and surgery. Some pharmacological agents to prevent gastrointestinal toxicity are under investigation.

show abstract

Chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy: a preliminary analysis

Cited by 49 publications

References 0 publications

Incorporation of magnetic resonance imaging into intensity modulated whole-pelvic radiation therapy treatment planning to reduce the volume of pelvic bone marrow irradiated

Incorporation of magnetic resonance imaging into intensity modulated whole-pelvic radiation therapy treatment planning to reduce the volume of pelvic bone marrow irradiated

Intensity-modulated radiation therapy in gynecologic malignancies

Gastrointestinal toxicity associated to radiation therapy

Contact Info

Product

Resources

About