Chronic gastritis and enterocolitis associated with<i>Leishmania</i>infection in an 18-month-old, intact female dog

Ruiz, Guillaume; Laloy, Eve; Benchekroun, Ghita

doi:10.1080/01652176.2015.1050529

Cited by 9 publications

(20 citation statements)

References 15 publications

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“…While renal disease, vasculitis, ocular and join disease have been observed less frequently, these are indicators of a worse prognosis because they are clinical signs related to immunocomplex deposition [48][49][50][51][52]. Additionally, other clinical signs have been sporadically observed such as neurological signs [53][54][55][56][57] or digestive disorders [58][59][60]. Although these signs could due to CanL, other diseases must be considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

et al. 2020

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Background: Canine leishmaniosis (CanL) is a parasitic zoonotic disease, endemic in the Mediterranean basin including Spain. While knowledge about CanL, its management, treatment, prevention and control mounts, it remains unclear whether all clinical veterinarians follow the same international recommendations, such as those of the LeishVet group. This study was thus designed to assess recent trends in the clinical management of CanL in veterinary clinics across Spain through a questionnaire-based survey. Results were compared with those of a prior national multicenter questionnaire administered by our research team in 2005.

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Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

et al. 2020

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“…The interpretation of clinicopathologic, serologic, and molecular tests should take into account the history (eg, exposure to phlebotomine vectors), signalment (male dogs > 2 years are at high risk), and clinical presentation. The latter is characterized by a wide spectrum of clinical presentations, ranging from infections characterized by the absence of overt clinical findings in the presence of obvious laboratory abnormalities, to more or less marked clinical and laboratory abnormalities that may require hospitalization, especially in cases with severe life‐threatening complications …”

Section: Clinical Signs Of Canine Leishmaniasismentioning

confidence: 99%

“…The latter is characterized by a wide spectrum of clinical presentations, ranging from infections characterized by the absence of overt clinical findings in the presence of obvious laboratory abnormalities, to more or less marked clinical and laboratory abnormalities that may require hospitalization, especially in cases with severe life-threatening complications. [14][15][16][17][18][19][20][21][22][23][24][25][26]…”

Section: Clinical Signs Of Canine Leishmaniasismentioning

confidence: 99%

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

142

232

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Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α - and/or γ-globulins). Although a potential gammopathy is usually polyclonal, it may also appear oligo- or monoclonal, especially in dogs coinfected by other vector-borne pathogens. When lesions are accessible to fine-needle aspiration (lymphoadenomegaly, nodular lesions, joint swelling), cytology is strongly advised, as the presence of Leishmania amastigotes in a pattern of pyogranulomatous inflammation or lymphoplasmacytic hyperplasia is diagnostic. If the cytologic pattern is inconclusive, the parasite should be identified by histology/immunohistochemistry or PCR on surgical biopsies. Alternatively, cytology and PCR may be performed on bone marrow samples where amastigotes, along with erythroid hypoplasia, myeloid hyperplasia, plasmacytosis, or secondary dysmyelopoiesis can be observed. Dogs with overt leishmaniasis generally have high antibody titers, while low titers predominate in immunologically resistant infected dogs or in exposed dogs with no parasite confirmation. Quantitative serology is recommended in clinically suspect dogs as high-titer antibodies titers may confirm the clinical diagnosis. In confirmed and treated dogs, renal function and inflammatory/immune response variables should be periodically monitored.

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“…While renal disease, vasculitis, ocular and join disease have been less frequently observed, these are indicators of a worse prognosis because they are clinical signs related to immunocomplex deposition [44,45,46,47,48]. Besides, other clinical signs have been sporadically observed such as neurological signs [49,50,51,52,53] or digestive disorders [54,55,56]. Although these signs could due to CanL, other diseases must be considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain (Part II): current clinical management and control according to a national survey in practitioners

Montoya

Gálvez

Checa

et al. 2020

Preprint

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Background Canine leishmaniosis (CanL) is a parasitic zoonotic disease, endemic in the Mediterranean basin including Spain. While knowledge about CanL, its management, treatment, prevention and control mounts, it remains unclear whether all clinical veterinarians follow the same international recommendations, such as those of the LeishVet group. This study was thus designed to assess recent trends in the clinical management of CanL in veterinary clinics across Spain through a questionnaire-based survey. Results were compared with those of our prior national multicenter questionnaire administered by our research team in 2005. Methods A questionnaire consisting of 28 questions about CanL was developed using Google Forms and distributed by email to 1428 veterinary clinics in Spain. Questions were designed to obtain data on common clinical signs, techniques and complementary exams used to diagnose the disease, and on its monitoring, treatment and control measures. Data were collected in a database for statistical analysis. Results Completed questionnaires were returned by 295 clinics. Compared to the situation in 2005, replies indicate that clinical signs of CanL have not changed significantly, cutaneous lesions being still the most prevalent sign observed by practitioners. Quantitative serological techniques are considered an adequate approach to diagnosis, provided their results are supported by the findings of a thorough physical exam, as well as complementary tests (complete blood count (CBC), biochemical profile, plasma protein electrophoretogram and complete urinalysis). Treatment protocols and check-ups follow international recommendations. Finally, a multimodal approach is being endorsed to adequately control CanL including preventive measures such as: annual serological check-ups and the combination of repellents and vaccines. Besides, owners are being better informed about CanL by veterinarians, which translates to the improved control of this zoonosis. Conclusions The clinical management of CanL has recently undergone significant changes owing to improvements in clinical knowledge of the disease, more unified international criteria, improved diagnostic techniques and their adequate interpretation, as well as a greater awareness of the disease transmitted to owners.

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Chronic gastritis and enterocolitis associated withLeishmaniainfection in an 18-month-old, intact female dog

Cited by 9 publications

References 15 publications

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Latest trends in L. infantum infection in dogs in Spain (Part II): current clinical management and control according to a national survey in practitioners

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