Chronic fungal osteomyelitis of the tibia due to Acremonium curvulum: a rare case

Khan, Sadia Hayat; Kumar, Anil; Bhaskaran, VK; Chandran, Sabthami; Dinesh, K.K.J. Ranga

doi:10.11604/pamj.2019.34.173.13737

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…In the current study, Acremonium was isolated from a patient with mycetoma. It was also previously reported to cause keratitis, 111 , 112 osteomyelitis, 113 , 114 disseminated infection, 115–118 brain abscess, 119 pulmonary infections, 120–122 meningitis, 123–125 endocarditis, 126 subcutaneous infections, 127–130 and peritonitis. 131 , 132 …”

Section: Discussionmentioning

confidence: 85%

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

et al. 2022

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Due to an increasing number of patients at risk, (i.e., those with a highly compromised immune system and/or receiving aggressive chemotherapy treatment), invasive fungal infections (IFI) are increasingly being reported and associated with high mortality rates. Aspergillus spp., particularly A. fumigatus, is the major cause of IFI caused by filamentous fungi around the world followed by Fusarium spp., however, other fungi are emerging as human pathogens. The aim of this study was to explore the epidemiology and prevalence of the non-Aspergillus and non-Fusarium filamentous fungi in human clinical samples over an 11-years period in Qatar using molecular techniques. We recovered 53 filamentous fungal isolates from patients with various clinical conditions. Most patients were males (75.5%), 9.4% were immunocompromised, 20.7% had IFI, and 11.3% died within 30 days of diagnosis. The fungal isolates were recovered from a variety of clinical samples, including nasal cavity, wounds, respiratory samples, body fluids, eye, ear, tissue, abscess, and blood specimens. Among the fungi isolated, 49% were dematiaceous fungi, followed by Mucorales (30%), with the latter group Mucorales being the major cause of IFI (5/11, 45.5%). The current study highlights the epidemiology and spectrum of filamentous fungal genera, other than Aspergillus and Fusarium, recovered from human clinical samples in Qatar, excluding superficial infections, which can aid in surveillance of uncommon and emerging mycoses.

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Section: Discussionmentioning

confidence: 85%

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

et al. 2022

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“…We also suggest that early initiation of treatment, and removal of the source of infection are the important steps in achieving a good clinical response in treatment of infections by Acremonium spp. [21,22].…”

Section: Case Reportmentioning

confidence: 99%

Skin ulcerative lesion induced by Acremonium species

Mastroianni,

Vangeli,

Mauro

et al. 2023

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Acremonium (Cephalosporium) species are environmentally widespread saprophytes and considered ubiquitous fungal organisms found in soil and air, but in recent years they have been described increasingly as opportunistic microorganisms in immunocompetent patients that have sustained skin injuries. In recent years, the incidence of invasive infections caused by Acremonium species (spp.) has increased probably as a result of more aggressive modern medical modalities such as chemotherapy, transplantation, intravascular central line insertion, prosthetic valves, and dialysis access grafts and more frequent and widespread use of immunosuppressive agents. An intriguing report of a large cutaneous ulcerative lesion by Acremonium spp. is discussed on the ground of the existing literature in this field. The literature search showed only three cases of ulcerative lesions of the skin due to Acremonium spp. infection. There are no standard therapy guidelines for the treatment of these infections, so we aim to summarize and discuss the currently available data on the promising results obtained with voriconazole for the treatment of these ulcerative skin infections. Clinical experience with other drugs, such as VRC is very encouraging.

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“…Candida spp and Aspergillus are responsible for most of these illnesses. Fungal OM is also thought to be caused by dimorphic fungi and Cryptococcus spp [11] …”

Section: Introductionmentioning

confidence: 99%

“…Fungal OM is also thought to be caused by dimorphic fungi and Cryptococcus spp. [11] There are currently no ideal classifications or treatment strategies for OM. There is an urgent need for better treatment techniques for OM due to its refractoriness, high cost, extended duration of care, and high incidence of impairment.…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

Das,

Ringu,

Ghosh

et al. 2024

ChemistrySelect

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Osteomyelitis (OM), a debilitating disease caused by a microbial infection of the bones, continues to pose a formidable obstacle for orthopedic surgeons. The conventional methods for the prevention and treatment of OM are insufficient. In this research work, we developed a strategic green nanostructure using the antifungal drug Fluconazole (FCZ)‐assimilated zinc oxide nanoparticles (ZnO‐NPs) and hydroxyapatite (HAp) nanostructures as filler and hydrophobic polycaprolactone (PCL) as matrix by a solution‐based chemical method. The ceramic carrier‐like nanostructures ZnO and HAp were synthesized by the in situ precipitation method. The physicochemical characterization of the prepared polymer‐coated drug ceramic nanocomposite (FCZ‐ZnO‐HAp‐PCL) was achieved using Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), particle size distribution (PSD), X‐ray diffraction (XRD), and Energy‐dispersive X‐ray (EDX) analysis. Furthermore, the biocompatibility and anticancer activity of the nanocomposite were explored by an MTT assay study. Successfully synthesized FCZ‐ZnO‐HAp‐PCL nanocomposite exhibited profound antimicrobial activity against targeted microbe species and potential cytotoxicity towards MCF‐7 human breast adenocarcinoma cell lines, which may be potentially used for the treatment of OM and prospective infections.

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Chronic fungal osteomyelitis of the tibia due to Acremonium curvulum: a rare case

Cited by 3 publications

References 11 publications

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

Skin ulcerative lesion induced by Acremonium species

Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

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