Chronic food restriction differentially affects NPY mRNA level in neurons of the hypothalamus and in neurons that innervate liver

Sucajtys-Szulc, Elzbieta; Goyke, Elżbieta; Korczyńska, Justyna; Stelmańska, Ewa; Rutkowski, Bolesław; Świerczyński, Julian

doi:10.1016/j.neulet.2008.01.004

Cited by 23 publications

(21 citation statements)

References 22 publications

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“…The results presented here ( Table 1) and in our previous paper [35], indicate an increase in serum corticosterone concentration in rats maintained on a restricted diet. Based on the data reported by Masuzaki et al [2], we considered the possibility that adipose tissue of rats challenged with restricted diet could release sufficient corticosterone into circulation to cause an increase in serum corticosterone level.…”

Section: Discussionsupporting

confidence: 81%

Chronic food restriction up-regulates 11-β-hydroxysteroid dehydrogenase

et al. 2011

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Corticosterone — product of 11-β-hydroxysteroid dehydrogenase type I (11βHSD1) stimulates adipocytes differentiation and activates lipogenic enzymes gene expression in white adipose tissue (WAT) of rats. The aim of the study was to examine the effect of chronic food restriction, often practised by obese individuals trying to lose body mass, on: a) 11βHSD1 gene expression, b) expression of genes associated with adipocyte differentiation (PPARg, SREBP-1, adiponectin), and c) expression of genes associated with lipogenesis in WAT of rats. Two-month old rats were divided into a control and a food restricted group obtaining 50% of food consumed by controls for 30 days. mRNA levels of studied genes in perirenal WAT were analysed by real-time PCR. 11βHSD1 and lipogenic enzymes activities were measured by radiometric conversion assay and by spectrophotometric assay respectively. Food restriction caused significant increase of 11βHSD1, PPARg, SREBP1, adiponectin and lipogenic enzymes mRNA levels in perirenal WAT. 11βHSD1 and some lipogenic enzymes activities were also increased by food restriction. The coordinated up-regulation of 11βHSD1, and genes associated with adipocyte differentiation and lipogenesis by food restriction suggests that such nutritional condition shifts WAT metabolism, that would permit this tissue to synthesize and accumulate triacylglycerols immediately after refeeding.

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Section: Discussionsupporting

confidence: 81%

Chronic food restriction up-regulates 11-β-hydroxysteroid dehydrogenase

et al. 2011

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“…It has been demonstrated that changes in body mass are regulated by food-limitation degree: if the degree of food restriction is lesser, animals can maintain their energy homeostasis and body weight balance by increasing the intestinal absorption efficiency, adjusting metabolic rate and changing activity. However, when the food-limitation degree is too severe, mammals can't maintain the energy balance, leading to a reduction of body mass (Sucajtys-Szulc et al 2008). In the present study, body mass in E. miletus decreased significantly during food deprivation, similarly to what was observed in mice ).…”

Section: Body Mass and Serum Leptin Levelssupporting

confidence: 68%

“…Physiological adjustment for body mass, energy intake and energy expenditure are the main energy strategies in mammals adapting to a changing environment, but recent research on the effects of food quantity on body mass and energy balance seems to be inconsistent (Liang & Zhang 2006). For example, food restriction induced a decrease of body mass in rats (Sucajtys-Szulc et al 2008), but had no effects in mice (Hambly & Speakman 2005). So it is unclear if animals could adjust the plasticity of the energy budget in order to adapt to changes in food resources on a short time scale.…”

Section: Introductionmentioning

confidence: 99%

Effects of random food deprivation on body mass, behavior and serum leptin levels inEothenomys miletus(Mammalia: Rodentia: Cricetidae)

Zhu

Yuan

Zhang

et al. 2014

Italian Journal of Zoology

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The value of phenotypic plasticity in energy metabolism and behavioral patterns in response to variations of food availability was handled in adult male voles (Eothenomys miletus) acclimated to random food deprivation (FD) for 4 weeks. During this period, in which voles were fed ad libitum for a randomly assigned 3 days each week, changes in body mass, food intake, resting metabolic rate (RMR), non-shivering thermogenesis (NST) and serum leptin levels were measured. Behavioral observations were made to examine behavioral patterns including activity, feeding, grooming and resting behaviors. The results showed that food intake and gastrointestinal mass increased significantly, but RMR and NST decreased significantly in the FD group compared to the control group. Moreover, the FD group had a significantly higher percentage of feeding behavior and lower activity than those in control group. In addition, serum leptin levels were positively correlated with body fat mass, but showed no significant differences between FD and the control group. These results suggest that E. miletus can compensate for an unpredictable reduction of food availability by engaging in an energetic strategy related to food intake and a decrease in energy expenditure associated with RMR, NST plus general activity, together with the mobilization of body fat as well as the adjustment of the gastrointestinal tract, which consequently play an important role in adaptations to food shortage in unpredictable environments.

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“…Under physiological conditions, various factors are involved in the regulation of neuropeptide genes expression [12,13]. Moreover, some studies have indicated that food restriction, fasting or refeeding affect neuropeptide genes expression in hypothalamus [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

Stelmańska

Sucajtys-Szulc²

2014

Endokrynologia Polska

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Enhanced food intake by progesterone-treated female rats is related to changes in neuropeptide genes expression in hypothalamusZwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu AbstractIntroduction: Progesterone-treated females eat more food, but the mechanism underlying this effect is not well understood. The aim of the study was to analyse the effect of progesterone on neuropeptide genes expression in rat hypothalamus. Material and methods: Experiments were carried out on female and male Wistar rats. Animals were treated with progesterone (100 mg per rat) for 28 days. NPY and CART mRNA levels in hypothalamus were quantified by real-time PCR. The serum progesterone concentration was determined by radioimmunoassay. Results: Progesterone administration to females caused an increase in food intake, body mass, and white adipose tissue mass. Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females. In males, elevated blood progesterone concentration had no effect on food intake, body and fat mass and on the neuropeptide genes expression in hypothalamus. Moreover, administration of progesterone in females resulted in decrease of PR mRNA level in hypothalamus. No effect of progesterone administration on PR mRNA level in hypothalamus of males was found. Conclusions: The changes in neuropeptide genes expression in hypothalamus may lead to stimulation of appetite and might explain the observed increase in food intake, body and adipose tissue mass in progesterone-treated females.

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Chronic food restriction differentially affects NPY mRNA level in neurons of the hypothalamus and in neurons that innervate liver

Cited by 23 publications

References 22 publications

Chronic food restriction up-regulates 11-β-hydroxysteroid dehydrogenase

Chronic food restriction up-regulates 11-β-hydroxysteroid dehydrogenase

Effects of random food deprivation on body mass, behavior and serum leptin levels inEothenomys miletus(Mammalia: Rodentia: Cricetidae)

Zwiększone spożycie pokarmu jest związane ze zmianami ekspresji genów neuropeptydów w podwzgórzu samic szczura po podaniu progesteronu

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