Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Baptista-de-Souza, Daniela; Tavares, Lígia Renata Rodrigues; Furuya-da-Cunha, Elke Mayumi; Oliveira, Paulo Eduardo Carneiro de; Canto-de-Souza, Lucas; Nunes-de-Souza, Ricardo Luiz; Canto-de-Souza, Azair

doi:10.3389/fphar.2020.00260

Cited by 9 publications

(1 citation statement)

References 80 publications

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“…In addition, the role of the 5HT2C serotonin receptor in the regulation of appetite, eating behavior, and body weight is not that clear. The only drug approved for the treatment of bulimia nervosa, fluoxetine, is known to block (similarly to clozapine and olanzapine) 5HT2C receptors [48] .…”

Section: Resultsmentioning

confidence: 99%

Pharmacological strategies for appetite modulation in eating disorders: a narrative review

Popov,

Lepik,

Kozlovskii

et al. 2023

Consortium Psychiatricum

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BACKGROUND: Over the past decades, a substantial increase in the prevalence of eating disorders (ED) has been noticed. In the treatment of ED priority is justifiably given to psychosocial interventions. However, it is well known that centrally acting drugs can significantly affect appetite and food consumption. AIM: The aim of this review is to analyze and summarize the available neurobiological data on the mechanisms of central regulation of eating behavior as a rationale for pharmacological strategies for appetite modulation in ED. METHODS: The authors have carried out a narrative review of scientific papers published from 2013 to 2023. The studies presented in the PubMed and Web of Science electronic databases were analyzed. Relevant studies were included regardless of their design. Descriptive analysis was used to summarize the information obtained. RESULTS: Neurobiological mechanisms of central regulation of eating behavior are reviewed. Pharmacological strategies for appetite modulation in ED based on neurobiological and clinical data are discussed. The influence of age on efficacy and safety of pharmacotherapy is also discussed, with an emphasis on adolescence. CONCLUSIONS: The progress in neurobiological understanding of the mechanisms of central regulation of appetite reveals the opportunities for new pharmacotherapeutic approaches aimed at changing the patterns of eating behavior. Obviously, treatment of ED is a much broader problem and cannot be reduced to the correction of food consumption. Nevertheless, at certain stages of treatment, drug-induced modulation of appetite can play an important role among multi-targeted biological and psychosocial interventions. Translation of neurobiological data into clinical practice requires a large number of clinical studies to confirm the long-term efficacy and safety of pharmacotherapeutic approaches and to develop personalized algorithms for the treatment of various forms of ED in different age groups.

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Section: Resultsmentioning

confidence: 99%

Pharmacological strategies for appetite modulation in eating disorders: a narrative review

Popov,

Lepik,

Kozlovskii

et al. 2023

Consortium Psychiatricum

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Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray

et al. 2022

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Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Govindula

Ranadive

Nampoothiri

et al. 2023

J Neuroimmune Pharmacol

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Post-traumatic stress disorder (PTSD) is a chronic incapacitating condition with recurrent experience of trauma-related memories, negative mood, altered cognition, and hypervigilance. Agglomeration of preclinical and clinical evidence in recent years specified that alterations in neural networks favor certain characteristics of PTSD. Besides the disruption of hypothalamus-pituitary-axis (HPA) axis, intensified immune status with elevated pro-inflammatory cytokines and arachidonic metabolites of COX-2 such as PGE2 creates a putative scenario in worsening the neurobehavioral facet of PTSD. This review aims to link the Diagnostic and Statistical Manual of mental disorders (DSM-V) symptomology to major neural mechanisms that are supposed to underpin the transition from acute stress reactions to the development of PTSD. Also, to demonstrate how these intertwined processes can be applied to probable early intervention strategies followed by a description of the evidence supporting the proposed mechanisms. Hence in this review, several neural network mechanisms were postulated concerning the HPA axis, COX-2, PGE2, NLRP3, and sirtuins to unravel possible complex neuroinflammatory mechanisms that are obscured in PTSD condition.

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Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Cited by 9 publications

References 80 publications

Pharmacological strategies for appetite modulation in eating disorders: a narrative review

Pharmacological strategies for appetite modulation in eating disorders: a narrative review

Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

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