Chronic Fatigue in Long-term Survivors of Childhood Lymphomas and Leukemia

Zeller, Bernward; Loge, Jon Håvard; Kanellopoulos, Adriani; Hamre, Hanne; Wyller, Vegard Bruun; Ruud, Ellen

doi:10.1097/mph.0000000000000051

Cited by 45 publications

(55 citation statements)

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“…Cancer‐related fatigue and sleep problems (sleep disturbance, sleep quality, and daytime sleepiness) are among the most common late effects following cancer . If left unmanaged, they can yield important work or school performance difficulties, which may lead to significant distress, anxiety, depression, and impaired quality of life . In fact, sleeping issues seemed to be key contributors to psychological health: both adolescents and adults in the present study were 2 to 10 times more likely to report anxiety, depression or distress if they had sleeping difficulty.…”

Section: Discussionmentioning

confidence: 59%

Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

Anestin

Lippé

Robaey

et al. 2018

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 59%

Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

Anestin

Lippé

Robaey

et al. 2018

Pediatric Blood & Cancer

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“…The CCSS is a large multi‐institutional cohort study of childhood cancer survivors in the United States and Canada . All studies compared the outcomes with one of the following: age‐matched population norms, both age‐matched norms and cancer groups, siblings, both siblings and age‐ and gender‐specific population norms, and other cancer/treatment groups . Three studies compared the samples over two or three time points, and one study compared the samples over three decades .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies compared the samples over two or three time points, and one study compared the samples over three decades . The sample sizes ranged from 388 to 16 079 in the longitudinal studies and from 27 to 14 566 in the cross‐sectional studies . Age at the time of evaluation was generally ≥18 years.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding diagnostic groups, 17 studies included patients with heterogeneous diagnoses . Furthermore, nine studies focused on specific homogenous subgroups of patients with diagnoses such as acute lymphoblastic leukaemia (ALL), leukaemia, lymphoma, Hodgkin's lymphoma, rhabdomyosarcoma, osteosarcoma, soft tissue sarcoma, Ewing's sarcoma, other bone tumours and CNS tumours …”

Section: Resultsmentioning

confidence: 99%

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A systematic review of self‐reported pain in childhood cancer survivors

Reinfjell

Zeltzer

2019

Acta Paediatrica

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Aim The aim of this systematic review was to examine the frequency and risk factors of pain among long‐term childhood cancer survivors based on self‐reported questionnaire studies. Participants aged 21 years or younger at the time of their cancer diagnosis were included. Methods The Medline (OVID), PubMed and PsycINFO databases were searched for manuscripts published between January 1, 1990, and August 31, 2018, following the PRISMA statement for reporting systematic reviews. Results In total, 25 studies, including five prospective cohort studies measuring pain up to 32 years post‐diagnosis, were identified. Female sex, young age at diagnosis, older age at assessment, greater time since diagnosis, specific diagnoses (such as central nervous system [CNS] tumours, bone tumours and sarcoma), fatigue and persistent emotional distress were associated with cancer‐related pain. The most common pain types were migraines, headaches and back pain. Conclusion A subset of childhood cancer survivors reported clinically significant self‐reported pain. Identifying survivor subgroups at risk for pain could be essential for developing tailored intervention and prevention strategies. Prospective studies that use standardised and psychometrically sound tools to evaluate pain are needed.

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“…In childhood cancer survivors, sleep disturbances are closely related to quality of life [11], and survivors reporting poor sleep quality are almost five times more likely to be depressed [3, 13]. Chronic fatigue is also related to higher reports of psychological distress in survivors who experience persistent chronic fatigue relative to survivors without a history of chronic fatigue [19]. Together with the increased risk for mood disturbances, anxiety, and poor quality of life [20, 21], AYA survivors with sleep and fatigue disturbances face high risk for poor psychosocial outcomes.…”

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confidence: 99%

Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls

Daniel

Kazak

et al. 2015

Support Care Cancer

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Purpose How cancer history and distress relate to sleep outcomes of adolescents and young adults (AYAs) is unclear. The current study compares AYA cancer survivors to controls on indicators of sleep and fatigue; examines the concurrent association between psychological status, sleep, and fatigue; and investigates the lagged relationship between sleep and fatigue problems with psychological functioning. Methods AYA cancer survivors (n=167) and controls (n= 170), ages 16 to 30, completed measures at a survivorship clinic/primary care visit (time 1) and 2 months later (time 2). Participants completed questions about sleep quality, quantity, sleep medication use, self-reports of sleep problems, and fatigue in addition to measures of depression, anxiety, and post-traumatic stress symptoms (PTSS). Results There were no differences in sleep quantity or quality between survivors and controls, but survivors reported significantly more fatigue. Within groups, AYAs with self-reported sleep and fatigue problems reported significantly higher depression, anxiety, and PTS symptoms. Controlling for baseline depression, sleep, and fatigue problems at time 1 significantly predicted depression at time 2 in survivors but not in controls. Conclusion This study offers important insight into the psychological functioning of childhood cancer survivors and prospectively describes sleep and fatigue as risk factors for poor psychological functioning in survivors. These findings support screening for sleep problems in AYA survivors as these difficulties are closely related to mental health functioning.

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Chronic Fatigue in Long-term Survivors of Childhood Lymphomas and Leukemia

Abstract: Long-term survivors of childhood cancer with PCF are characterized by more depressive symptoms, anxiety, pain, insomnia, and less physical activity.

Cited by 45 publications

References 10 publications

Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

A systematic review of self‐reported pain in childhood cancer survivors

Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls

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