Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

Anestin, Annélie S.; Lippé, Sarah; Robaey, Philippe; Bertout, Laurence; Drouin, Simon; Krajinović, Maja; Michon, Bruno; Rondeau, Émélie; Samoilenko, Mariia; Laverdière, Caroline; Sinnett, Daniel; Sultan, Serge

doi:10.1002/pbc.27356

Cited by 28 publications

(36 citation statements)

References 89 publications

(212 reference statements)

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“…A similar trend was seen for scoring moderate to extremely severe anxiety whereas levels of distress in YA ALL survivors and siblings were comparable. A prevalence for reporting depression, anxiety and stress in YA ALL survivors has been shown in studies from other contexts [10] and in comparison with siblings [40]. However, the levels of anxiety and distress found in our study were lower and were based on self-report rather than parent report.…”

Section: Discussioncontrasting

confidence: 71%

“…While the long-term prevalence of physical health problems has been more widely investigated, knowledge on the long-term prevalence of mental health problems remains scarce. Results indicate a higher prevalence of mental ill health [8,9] poorer self-image [9] and mild to severe anxiety and depression [10]. There are however studies that have found the opposite, that ALL survivors report better HRQoL healthy controls of similar age [11].…”

Section: Introductionmentioning

confidence: 99%

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Health related quality of life and buffering factors in adult survivors of acute pediatric lymphoblastic leukemia and their siblings

Aili

Arvidsson

Nygren

2021

Health Qual Life Outcomes

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Background The improvement in treatment of pediatric acute lymphatic leukemia (ALL) has introduced new challenges for pediatric oncology care in understanding and handling long-term treatment-related complications later in adult life. The aim of this study was to describe health related quality of life (HRQoL) and the relation to buffering factors among young adult (YA) pediatric ALL survivors and their siblings. Methods This cross-sectional study was performed among 227 adults, treated for pediatric ALL in Sweden between 1985 and 1997 and their siblings (n = 70). Group means of HRQoL (SF-36) were compared between YA ALL survivors and the siblings, as well as to normative values from the general population. Self-efficacy (GSES) and social support (SS-13 subscale AVSI) was considering potential buffering factors for HRQoL and mental health. Associations between HRQoL and mental health respectively and self-efficacy and social support was analyzed. Results The YA ALL survivors scored significantly lower on the HRQoL parameters general health (69.6 vs. 78.4, p = 0.004) and role emotional (77.1 vs. 88.1, p = 0.014), than the siblings. Further, they reported significantly lower general health (69.6 vs. 75.8), vitality (56.9 vs. 68.8), social functioning (84.5 vs. 88.6), role emotional (77.1 vs. 85.7) and mental health (71.3 vs. 80.9) compared with Swedish norms. Both YA ALL survivors and the siblings reported lower vitality and worse mental health than the general population. The HRQoL parameters, depression, stress and anxiety were all associated with both self-efficacy and social support among the YA ALL survivors. Among the siblings however, only general health, vitality, role emotional, mental health and depression were associated with social support, and only general health and mental health were associated with general self-efficacy. Conclusion The results from this study show that buffering factors, like social support and self-efficacy, may play an important role for psychosocial outcomes and HRQoL among YA ALL survivors later in life. The results suggest that this group could benefit from continuous support in adult life to handle consequences of their pediatric disease.

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Health related quality of life and buffering factors in adult survivors of acute pediatric lymphoblastic leukemia and their siblings

Aili

Arvidsson

Nygren

2021

Health Qual Life Outcomes

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“…The rates of neurocognitive deficits affecting executive function, processing speed and memory are threefold higher among survivors of childhood ALL than the general population (4,(6)(7)(8). Survivors also demonstrate behavioral and psychological problems (9)(10)(11), as well as worse academic performance (12,13).…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive and Behavioral Outcomes of Chinese Survivors of Childhood Lymphoblastic Leukemia

et al. 2021

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BackgroundIncreasing attention has been dedicated to investigate modifiable risk factors of late effects in survivors of childhood cancer. This study aims to evaluate neurocognitive and behavioral functioning in a relatively young cohort of survivors of childhood acute lymphoblastic leukemia (ALL) in Hong Kong, and to identify clinical and socio-environmental factors associated with these outcomes.MethodsThis analysis included 152 survivors of childhood ALL who were ≥5 years post-diagnosis (52% male, mean [SD] age 23.5[7.2] years at evaluation, 17.2[7.6] years post-diagnosis). Survivors completed performance-based neurocognitive tests, and reported their emotional and behavioral symptoms using the Child/Adult Behavior Checklist. Socio-environmental variables (living space, fatigue, physical activity, family functioning, and academic stress) were self-reported using validated questionnaires. Clinical variables and chronic health conditions were extracted from medical charts. Multivariable linear modeling was conducted to test identify factors associated with neurocognitive/behavioral outcomes, adjusting for current age, sex, age at diagnosis and cranial radiation. An exploratory mediation analysis was performed to examine the mediating effects of risk factors on neurocognitive and behavioral outcomes.ResultsAs compared to population norms, a minority of survivors developed mild-moderate impairment in motor processing speed (36.2%), memory (9.2%) and attention measures (4.0%-10.5%). Survivors also reported attention problems (12.5%), sluggish cognitive tempo (23.7%) and internalizing (depressive, anxiety and somatic symptoms) problems (17.1%). A minority of survivors developed mild-moderate treatment-related chronic conditions (n=37, 24.3%). As compared to survivors without chronic conditions, survivors with chronic conditions had more executive dysfunction (B=5.09, standard error [SE]=2.05; P=0.014) and reported more attention problems (B=5.73, SE=1.43; P<0.0001). Fatigue and poor family functioning was associated with multiple measures of behavior problems (all P<0.001). A lower level of physical activity was correlated with more self-reported symptoms of inattention (B= -1.12, SE=0.38, P=0.004) and sluggish cognitive tempo (B=-1.22, SE=0.41, P=0.003). Exploratory analysis showed that chronic health conditions were associated with behavioral measures through fatigue as the mediator.ConclusionThe majority of young Chinese survivors of ALL had normal cognitive and behavioral function. Regular monitoring of behavioral function should be performed on survivors who develop treatment-related chronic conditions. Health behavior and socio-environment factors may be potentially modifiable risk factors associated with health outcomes in survivors.

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“…We administered the translated versions of the 16D and 17D to two clinical samples, one being treated for PID, the other having recovered from pediatric cancer (Acute Lymphoblastic Leukemia (ALL)). These samples are drawn from larger studies (Abate et al, 2018 ; Anestin et al, 2018 ; Boulet-Craig et al, 2018 ; Lamore et al, 2020 ; Marcoux et al, 2017 ; Pépin et al, 2017 ; Sultan et al, 2017 ). Full sample description data are available in Tables S4-S5.…”

Section: Methodsmentioning

confidence: 99%

“…Full sample description data are available in Tables S4-S5. Descriptions of participants’ flow are available in the original study reports (Abate et al, 2018 ; Anestin et al, 2018 ; Boulet-Craig et al, 2018 ; Lamore et al, 2020 ; Marcoux et al, 2017 ; Pépin et al, 2017 ; Sultan et al, 2017 ). As we did not have hypotheses we did not calculate the required samples size.…”

Section: Methodsmentioning

confidence: 99%

French-language adaptation of the 16D and 17D Quality of Life measures and score description in two Canadian pediatric samples

Rondeau

Desjardins

Laverdière

et al. 2021

Health Psychology and Behavioral Medicine

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Purpose: The Health state descriptive system includes standardized self-administered instruments for measuring Health-Related Quality of Life (HRQoL) respectively among adolescents, and children. The objectives of the current study were: (1) to translate and adapt the pediatric-adolescent version 16D and 17D from English into French (Canada), (2) to demonstrate their feasibility in pediatric conditions. Methods: The translation methodology combined forward and back translations, and cognitive debriefing with eight adolescents and eight children. Four bilingual translators were involved in the process. We administered the translated versions to two clinical samples, being treated for Primary immunodeficiency (PID, n = 48, aged 14.1 years, 20 girls), and having recovered from pediatric Acute Lymphoblastic Leukemia (ALL, n = 153, aged 14.7 years, 77 girls). Results: Cognitive debriefing indicated that that the instructions, items, and response options were clear, easy to understand, and easy to answer. Adjustments were made for clarity. Translated versions were highly usable (measurement completion >90%). HRQoL levels were high for both samples (range 0.85-0.96). Participants reported lower levels if they were adolescents, particularly if they were girls. Older boys with PID reported a lower HRQoL than their counterparts with a history of ALL. PID and ALL patients mainly reported issues with discomfort and pain, concentration/learning, physical appearance, and psychological distress and sleeping, although to a different degree. Conclusion:The French-language versions of the 16D and 17D are easy to administer and may be used to identify problematic domains. Greater availability of translated versions of short evaluation tools may facilitate broader uptake of screening practices in pediatric care.

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Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

Cited by 28 publications

References 89 publications

Health related quality of life and buffering factors in adult survivors of acute pediatric lymphoblastic leukemia and their siblings

Health related quality of life and buffering factors in adult survivors of acute pediatric lymphoblastic leukemia and their siblings

Neurocognitive and Behavioral Outcomes of Chinese Survivors of Childhood Lymphoblastic Leukemia

French-language adaptation of the 16D and 17D Quality of Life measures and score description in two Canadian pediatric samples

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