Chronic Electrical Stimulation at Acupoints Reduces Body Weight and Improves Blood Glucose in Obese Rats via Autonomic Pathway

Liu, Jiemin; Jin, Haifeng; Foreman, Robert D.; Lei, Yong; Xu, Xiaohong; Li, Shiying; Yin, Jieyun; Chen, Jiande D.Z.

doi:10.1007/s11695-014-1521-6

Cited by 20 publications

(14 citation statements)

References 35 publications

(50 reference statements)

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“…For EA, we used an innovative method, chronic EA, by implanting a pair of electrodes into bilateral ST36 acupoints instead of acutely penetrating acupuncture needles into points. 21 This method has been used for several studies in our laboratory and the advantage of it is that it can avoid stress coming from acupuncture needling, and furthermore it is more inconvenient for repeatable and chronic experiment.…”

Section: Discussionmentioning

confidence: 99%

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Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Zhang

Liu

et al. 2018

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

“…A third pair of the electrode wires was implanted into bilateral ST36 (5 mm below head of fibula under knee joint, 2 mm lateral to the anterior tubercle of the tibia of the hind leg) using a previously established method for EA. 21 All connecting wires were tunneled subcutaneously to and brought out at the back of the neck.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Zhang

Liu

et al. 2018

Neurogastroenterology Motil

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“…Recently, there appears to be a growing interest among researchers on the role of acupuncture in disease prevention and treatment. Some animal studies have found that acupuncture can exert significant effects on the treatment of obesity [23–25]. Acupuncture, a time-honored tradition in Chinese Medicine, has been proven to be an effective weight-loss medication.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture Regulating Gut Microbiota in Abdominal Obese Rats Induced by High-Fat Diet

Wang

Liang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effects of acupuncture on metabolic health and gut microbiota dysbiosis in diet-induced abdominal obese model. Materials and Methods. Male Sprague-Dawley rats were randomly distributed into normal chow diet (NCD) group and high-fat diet (HFD) group. After 12 weeks of HFD feeding, an abdominal obese rat model was established. The abdominal obese rats were further assigned to acupuncture group (n=7) and nontreated HFD group (n=7). Acupuncture was applied to bilateral GB 26 of rats for 8 weeks. Subsequently, the body weight, waist circumference (WC), visceral fat mass, and liver weight were measured weekly in all rats. Metabolic parameters such as total cholesterol, triglyceride, alanine aminotransferase, aspartate transaminase, and blood glucose were measured by an automatic biochemical analyzer. The serum levels of insulin (INS) were determined using Rat INS ELISA Kit. Analysis of gut microbiota was carried out by 16S rRNA gene sequencing. Results. Acupuncture decreased the body weight, WC, and visceral adipose tissues of HFD-induced abdominal obese rats. In addition, insulin sensitivity, glucose homeostasis, and lipid metabolism were improved by this treatment. Furthermore, electroacupuncture effectively modified the composition of gut microbiota, mainly via decreasing Firmicutes/Bacteroidetes ratio and increasing Prevotella_9 abundance. Conclusions. Electroacupuncture can ameliorate abdominal obesity and prevent metabolic disorders in HFD-induced abdominal obese rats, via the modulation of gut microbiota.

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“…This is a painful and stressful event to the animal and could induce unwanted stress effects. To resolve these issues, a novel method of EA has been proposed in our laboratory 32 : For animal research, EA is performed using chronically implanted electrodes at acupoints. This would avoid any stress effects each time during the insertion of the acupuncture needle.…”

Section: Discussionmentioning

confidence: 99%

Autonomically mediated anti‐inflammatory effects of electrical stimulation at acupoints in a rodent model of colonic inflammation

Jin

Guo²,

Liu

et al. 2019

Neurogastroenterology Motil

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Background Acupuncture has been widely accepted for treatments of many diseases. This study was performed to determine effects and mechanisms of electroacupuncture (EA) by chronically implanted electrodes at acupoint ST36 on colonic inflammation induced by TNBS in rats. Methods After intrarectal administration of TNBS, the rats were treated with sham‐EA, EA1/EA2 (two sets of parameters) for 3 weeks. Disease activity index (DAI), macroscopic and microscopic lesions, plasma levels of TNF‐α, IL‐1β and IL‐6 were observed as evaluation of inflammatory responses. The autonomic function was assessed by analysis of the heart rate variability. Results (a) Vagal activity was significantly increased with both acute and chronic EA1/EA2; (b) DAI was significantly decreased with both chronic EA1 and EA2, and EA2 was more potent than EA1 (P < 0.05); (c) The macroscopic score was 6.4 ± 0.6 with sham‐EA and reduced to 4.9 ± 0.1 with EA1 (P < 0.05) and 4.0 ± 0.2 with EA2 (all P < 0.05). The histological score was 4.05 ± 0.58 with sham‐EA and remained unchanged (3.71 ± 0.28) with EA1 (P > 0.05) but reduced to 3.0 ± 0.3 with EA2 (P < 0.01); (d) The plasma levels of TNF‐α, IL‐1β and IL‐6 were significantly decreased with EA2. Conclusions Electrical stimulation at ST36 improves colonic inflammation in TNBS‐treated rats by inhibiting pro‐inflammatory cytokines via the autonomic mechanism.

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Chronic Electrical Stimulation at Acupoints Reduces Body Weight and Improves Blood Glucose in Obese Rats via Autonomic Pathway

Abstract: CEA at ST-36 reduces body weight and improves blood glucose possibly attributed to multiple mechanisms involving gastrointestinal motility and hormones via the autonomic pathway.

Cited by 20 publications

References 35 publications

Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Acupuncture Regulating Gut Microbiota in Abdominal Obese Rats Induced by High-Fat Diet

Autonomically mediated anti‐inflammatory effects of electrical stimulation at acupoints in a rodent model of colonic inflammation

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