Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Zhang, S.; Li, S.; Liu, Y.; Ye, F.; Yin, Jieyun; Foreman, Robert D.; Wang, D.; Chen, J. D. Z.

doi:10.1111/nmo.13381

Cited by 21 publications

(20 citation statements)

References 57 publications

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“…Accordingly, a pre‐experiment was performed to determine the EA stimulation amplitude that was tolerable by all rats and 2 mA was found to be the most suitable value. It was a well‐established set of parameters that had been proven effective in treating gastrointestinal motility and functional dyspepsia . With our methods (our specific parameters in animals and humans), electrical stimulation at non‐acupoints has been shown ineffective in altering gastrointestinal motility as shown in numerous previous studies .…”

Section: Methodsmentioning

confidence: 91%

Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin

Liu

Zhang

Feng

et al. 2018

Neurogastroenterology Motil

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Background Chemotherapy‐associated dyspepsia syndrome (CADS) is among the most intensive side effects and critical concerns for patients with cancer. To investigate the effects and mechanisms of chronic electroacupuncture (EA) at ST36 on chemotherapy‐associated dyspeptic symptoms (CADS) in rats. Methods Cisplatin (8 mg/kg, ip) was given once to establish CADS model. EA or sham‐EA treatment was then performed one hour daily for 21 days. Key Results (a) EA treatment decreased kaolin intake within 24 hours (1.67 ± 0.23 g vs 2.36 ± 0.37 g in sham‐EA, P < 0.05); EA increased food intake (9.43 ± 2.28 vs 4.32 ± 1.26 in sham‐EA, P < 0.05) and cisplatin‐induced reduction of body weight (426.38 ± 13.25 vs 407.92 ± 13.26 in sham‐EA, P = 0.05). (b) The incidence of normal behavioral satiety sequence (53%) in EA group was greater than that in sham‐EA (32%) group (X2 = 17.68, P < 0.01). (c) EA increased the percentage of normal gastric slow waves (82.6 ± 5.98 vs 22.8 ± 1.90 in sham‐EA, P < 0.05). (d) EA normalized cisplatin delayed gastric emptying (71.3% ± 6.8% vs 44.6% ± 11.2% in control, P < 0.05). (e) EA decreased ratio of heart rate variability (0.30 ± 0.03 vs 0.56 ± 0.05 in sham‐EA, P < 0.05). (f) EA decreased fasting ghrelin, glucagon‐like peptide‐1 and peptide YY (P < 0.01 vs sham‐EA for all). Conclusions and Inferences Chronic EA ameliorates dyspepsia symptom and improves gastric dysmotility induced by Cisplatin, mediated via the vagal and gastrointestinal hormonal mechanisms.

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Section: Methodsmentioning

confidence: 91%

Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin

Liu

Zhang

Feng

et al. 2018

Neurogastroenterology Motil

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“…Evidence has shown that gastrointestinal diseases are accompanied by ANS dysfunction ( Zhang S. et al, 2018 ). By detecting 24-h HRV, gastrointestinal motility, and gastric acid secretion, Tominaga et al (2016) found that patients with functional dyspepsia had increased sympathetic tone and decreased vagal reactivity and that patients with ANS disorders had more serious gastrointestinal symptoms with higher indigestion scores.…”

Section: Acupuncture Is Effective In Alleviating Autonomic Nervous Sy...mentioning

confidence: 99%

The autonomic nervous system: A potential link to the efficacy of acupuncture

Wang

et al. 2022

Front. Neurosci.

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The autonomic nervous system (ANS) is a diffuse network that regulates physiological systems to maintain body homeostasis by integrating inputs from the internal and external environment, including the sympathetic, parasympathetic, and enteric nervous systems (ENS). Recent evidence suggests that ANS is one of the key neural pathways for acupuncture signal transduction, which has attracted worldwide attention in the acupuncture field. Here, we reviewed the basic and clinical research published in PubMed over the past 20 years on the effects of acupuncture on ANS regulation and homeostasis maintenance. It was found that acupuncture effectively alleviates ANS dysfunction-associated symptoms in its indications, such as migraine, depression, insomnia, functional dyspepsia, functional constipation. Acupuncture stimulation on some specific acupoints activates sensory nerve fibers, the spinal cord, and the brain. Using information integration and efferents from a complex network of autonomic nuclei of the brain, such as the insular cortex (IC), prefrontal cortex, anterior cingulate cortex (ACC), amygdala (AMG), hypothalamus, periaqueductal gray (PAG), nucleus tractus solitarius (NTS), ventrolateral medulla (VLM), nucleus ambiguus (AMB), acupuncture alleviates visceral dysfunction, inflammation via efferent autonomic nerves, and relieves pain and pain affect. The modulating pattern of sympathetic and parasympathetic nerves is associated with acupuncture stimulation on specific acupoints, intervention parameters, and disease models, and the relationships among them require further exploration. In conclusion, ANS is one of the therapeutic targets for acupuncture and mediates acupuncture’s actions, which restores homeostasis. A systemic study is needed to determine the rules and mechanisms underlying the effects of acupoint stimulation on corresponding organs mediated by specific central nervous networks and the efferent ANS.

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“…The enhancement of vagal activity with EA/TEA was reported in several previous studies and considered as one of major mechanisms involved in the prokinetic effects of EA/TEA. 39,40 EA at ST36 was reported to improve gastric slow waves in a rat model of FD 39 and normalize impaired colonic motility induced by rectal distension in dogs 40 ; the prokinetic effects were inhibited by atropine, an antagonist of acetylcholine (Ach). 39,40 The increase in vagal activity was reported to be associated with the improvement of dyspepsia symptoms in FD patients with the TEA treatment at PC6 and ST36.…”

Section: Autonomic-endocrine Mechanisms Of Teamentioning

confidence: 99%

“…39,40 EA at ST36 was reported to improve gastric slow waves in a rat model of FD 39 and normalize impaired colonic motility induced by rectal distension in dogs 40 ; the prokinetic effects were inhibited by atropine, an antagonist of acetylcholine (Ach). 39,40 The increase in vagal activity was reported to be associated with the improvement of dyspepsia symptoms in FD patients with the TEA treatment at PC6 and ST36. 6 Moreover, vagal nerve activation has been reported to exert anti-inflammatory effects in several experimental and clinical studies.…”

Section: Autonomic-endocrine Mechanisms Of Teamentioning

confidence: 99%

Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

Xuan

Zhu

et al. 2021

Neurogastroenterology Motil

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Background/Aims Gastrointestinal (GI) dysmotility in acute pancreatitis (AP) aggravates inflammation and results in severe complications. This study aimed to explore effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) on abdominal pain, GI dysmotility, and inflammation in AP patients. Methods Forty‐two AP patients were blindly randomized to receive TEA (n = 21) at acupoints PC6 and ST36 or Sham‐TEA (n = 21) at sham points for 2 days. Symptom scores, gastric slow waves, autonomic functions (assessed by spectral analysis of heart rate variability), circulatory levels of motilin, ghrelin, and TNF‐α were measured before and after the treatment. Sixteen healthy controls (HCs) were also included without treatment for the assessment of gastric slow waves and biochemistry. Key Results Compared with Sham‐TEA, TEA decreased abdominal pain score (2.57 ± 1.78 vs. 1.33 ± 1.02, p < 0.05), bloating score (5.19 ± 1.21 vs. 0.76 ± 0.99, p < 0.001), the first defecation time (65.79 ± 19.51 h vs. 51.38 ± 17.19 h, p < 0.05); TEA, but not Sham‐TEA, improved the percentage of normal gastric slow waves by 41.6% (p < 0.05), reduced AP severity score (5.52 ± 2.04 vs. 3.90 ± 1.90, p < 0.05) and serum TNF‐α (7.59 ± 4.80 pg/ml vs. 4.68 ± 1.85 pg/ml, p < 0.05), and upregulated plasma ghrelin (0.85 ± 0.96 ng/ml vs. 2.00 ± 1.71 ng/ml, p = 0.001) but not motilin (33.08 ± 22.65 pg/ml vs. 24.12 ± 13.95 pg/ml, p > 0.05); TEA decreased sympathetic activity by 15.0% and increased vagal activity by 18.3% (both p < 0.05). Conclusions & Inferences TEA at PC6 and ST36 administrated at early stage of AP reduces abdominal pain, improves GI motility, and inhibits inflammatory cytokine, TNF‐α, probably mediated via the autonomic and ghrelin mechanisms.

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Electroacupuncture via chronically implanted electrodes improves gastric dysmotility mediated by autonomic‐cholinergic mechanisms in a rodent model of functional dyspepsia

Abstract: Gastric motility (GSW and GE) is impaired in rats treated with IA, possibly attributed to impaired autonomic functions. EA improves GSW and accelerates GE mediated via the autonomic and cholinergic mechanisms.

Cited by 21 publications

References 57 publications

Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin

Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin

The autonomic nervous system: A potential link to the efficacy of acupuncture

Integrative effects of transcutaneous electrical acustimulation on abdominal pain, gastrointestinal motility, and inflammation in patients with early‐stage acute pancreatitis

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