“…8). Existing evidence indicates that ischemic neuroprotection of PUFAs in chronic dietary supplementation or single injection prior to injury involves stabilization of membrane integrity, improvement of local cerebral blood flow, blockade of glutamatergic transmission, reduction of eicosanoid production, enhancement of antioxidative capacity and/or induction of chaperon proteins [17,26,[28][29][30][31][32][33][34][35]. In comparison with those proposed neuroprotective mechanisms, we found that the beneficial effects of DHA preadministration on ischemic brain injury were well associated with the reduction of oxidative burden, elevation of Bcl-2 expression and/or stimulation of ERK activity.…”