Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD)

Pires, Vanessa Arânega; Pamplona, Fabrício A.; Pandolfo, Pablo; Prediger, Rui Daniel; Takahashi, Reinaldo Ν.

doi:10.1016/j.bbr.2010.06.022

Cited by 41 publications

(39 citation statements)

References 54 publications

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“…This is in line with the proposal of adenosine receptor antagonist caffeine as an alternative pharmacological treatment of ADHD (Pires et al . ), which could be plausible as the arousing effects of caffeine are due to ADORA2A antagonism (Fredholm et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the role of adenosine in sleep–wake homeostasis, with adenosine levels in the brain increasing with prolonged wakefulness and decreasing with sleep (Porkka‐Heiskanen ), lends further support to the notion of an involvement of adenosine in ADHD (Pires et al . ), given the empirical support for an association between ADHD and sleep/alertness alterations (Cortese et al . ).…”

mentioning

confidence: 99%

“…The blockade of ADORA2A in these animals confers improvement in learning impairments (Pires et al . , ). In the same vein, genetic knockout of ADORA2A has been linked to modified psychomotor behavior in mice (Ledent et al .…”

mentioning

confidence: 99%

“…Studies on spontaneously hypertensive rats have been used as an animal model of ADHD as they display hyperactivity, impulsivity and attention problems (Takahashi et al 2008). The blockade of ADORA2A in these animals confers improvement in learning impairments (Pires et al 2009(Pires et al , 2010. In the same vein, genetic knockout of ADORA2A has been linked to modified psychomotor behavior in mice (Ledent et al 1997).…”

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confidence: 99%

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A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

Molero¹,

Gumpert²,

Serlachius³

et al. 2013

Genes Brain and Behavior

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The adenosine A 2A receptor (ADORA2A) is linked to the dopamine neurotransmitter system and is also implicated in the regulation of alertness, suggesting a potential association with attention-deficit hyperactivity disorder (ADHD) traits. Furthermore, animal studies suggest that the ADORA2A may influence ADHD-like behavior. For that reason, the ADORA2A gene emerges as a promising candidate for studying the etiology of ADHD traits. The aim of this study was to examine the relationship between ADORA2A gene polymorphisms and ADHD traits in a large population-based sample. This study was based on the Child and Adolescent Twin Study in Sweden (CATSS), and included 1747 twins. Attention-deficit hyperactivity disorder traits were assessed through parental reports, and samples of DNA were collected. Associations between six single nucleotide polymorphisms (SNPs) and ADHD traits were examined, and results suggested a nominal association between ADHD traits and three of these SNPs: rs3761422, rs5751876 and rs35320474. For one of the SNPs, rs35320474, results remained significant after correction for multiple comparisons. These results indicate the possibility that the ADORA2A gene may be involved in ADHD traits. However, more studies replicating the present results are warranted before this association can be confirmed.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

Molero¹,

Gumpert²,

Serlachius³

et al. 2013

Genes Brain and Behavior

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“…when animals are 63-70 days old) (Pires, Pamplona, Pandolfo, Prediger, & Takahashi, 2010), yet continuing caffeine treatment throughout pre-adolescence, adolescence, and adulthood (between postnatal days 21 and 90) enhances novel object recognition memory when the rats are tested while remaining on caffeine (Abreu, Silva-Oliveira, Moraes, Pereira, & Moraes-Santos, 2011). Furthermore, Ardais and colleagues (2014) demonstrated that exposure to chronic caffeine during adolescence enhances novel object recognition when animals are tested with caffeine on board later in adolescence.…”

Section: Introductionmentioning

confidence: 99%

Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice

Poole

Braak

Gould

2016

Behavioural Brain Research

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Chronic caffeine exerts negligible effects on learning and memory in normal adults, but it is unknown whether this is also true for children and adolescents. The hippocampus, a brain region important for learning and memory, undergoes extensive structural and functional modifications during pre-adolescence and adolescence. As a result, chronic caffeine may have differential effects on hippocampus-dependent learning in pre-adolescents and adolescents compared with adults. Here, we characterized the effects of chronic caffeine and withdrawal from chronic caffeine on hippocampus-dependent (contextual) and hippocampus-independent (cued) fear conditioning in pre-adolescent, adolescent, and adult mice. The results indicate that chronic exposure to caffeine during pre-adolescence and adolescence enhances or impairs contextual conditioning depending on concentration, yet has no effect on cued conditioning. In contrast, withdrawal from chronic caffeine impairs contextual conditioning in pre-adolescent mice only. No changes in learning were seen for adult mice for either the chronic caffeine or withdrawal conditions. These findings support the hypothesis that chronic exposure to caffeine during pre-adolescence and adolescence can alter learning and memory and as changes were only seen in hippocampus-dependent learning, this suggests that the developing hippocampus may be sensitive to the effects of caffeine.

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Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence

Santos

Lima

2016

Molecular and Integrative Toxicology

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Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD)

Cited by 41 publications

References 54 publications

A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice

Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence

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Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD)

Cited by 41 publications

References 54 publications

A study of the possible association between adenosine A2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

A study of the possible association between adenosine A2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice

Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence

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Product

Resources

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A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits

A study of the possible association between adenosine A_2A receptor gene polymorphisms and attention‐deficit hyperactivity disorder traits