Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence

Santos, Roseane Maria Maia; Lima, Darcy Roberto Andrade

doi:10.1007/978-3-319-27449-2_11

Cited by 1 publication

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“…Growing data have shown that the daily consumed product implies negative affect on both central nervous system and cardiovascular system (Nehlig et al, 1992 ; Zulli et al, 2016 ; Grant et al, 2018 ). It has also been reported that caffeine can easily penetrate the mammalian placenta and can increase the risk of causes of teratogenesis in young fetuses (Santos and Lima, 2016 ; Yadegari et al, 2016 ). Caffeine consumption (>300 mg/day) during pregnancy was associated with an increased risk of fetal growth restriction, and this association continued throughout pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

et al. 2021

Front. Cell Dev. Biol.

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Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA expressions of genes involved in myogenesis in the developing chicken embryos. We then used embryo cultures to assess in further detail how caffeine exposure affects the earliest steps of myogenesis, and we demonstrated that the caffeine treatment suppressed somitogenesis of chicken embryos by interfering with the expressions of crucial genes modulating apoptosis, proliferation, and differentiation of myogenic progenitors in differentiating somites. These phenotypes were abrogated by a retinoic acid (RA) antagonist in embryo cultures, even at low caffeine doses in C2C12 cells, implying that excess RA levels are responsible for these phenotypes in cells and possibly in vivo. These findings highlight that excessive caffeine exposure is negatively involved in regulating the development of myogenic progenitors through interfering with RA signaling. The RA somitogenesis/myogenesis pathway might be directly impacted by caffeine signaling rather than reflecting an indirect effect of the toxicity of excess caffeine dosage.

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Section: Discussionmentioning

confidence: 99%

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Coffee Health Effects from Early Fetal Development Through Childhood and Adolescence

Cited by 1 publication

References 75 publications

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

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