Chronic administration of imipramine antagonizes deranged circadian rhythm phases in individually housed rats

Greco, Anna Maria; Gambardella, P; Sticchi, R; D'Aponte, D; Franciscis, P De

doi:10.1016/0031-9384(90)90262-3

Cited by 15 publications

(7 citation statements)

References 9 publications

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“…Similarly inconsistent results have been reported for imipramine, an unspecific monoamine reuptake inhibitor. In rats, imipramine delays the phase position of many brain receptor rhythms (43) and restores abnormally phaseadvanced endocrine rhythms of isolation-stressed rats to the normal phases found in controls (13). On the other hand, imipramine did not affect the phase position or rate of reentrainment of circadian activity rhythms in hamsters (2), and no significant effects on the period length could be observed in rats (36) or hamsters (45).…”

Section: Discussionmentioning

confidence: 85%

“…Lithium, the first and most extensively studied psychoactive drug, lengthens the freerunning rhythm and delays the phase position in a variety of species, including marine algae, higher plants, insects, mammals, and humans [for summaries, see (8,43,44)). Other antidepressant drugs that lengthen or phase delay circadian rhythms in mammals are clorgyline (7 ,25,37 ,45), a monoamine oxidase (MAO) type A inhibitor, pargyline (30,42), a mixed MAO type A and B inhibitor, and imipramine (13,25,43), a tricyclic monoamine reuptake inhibitor. However, the period-lengthening effect of imipramine seems less robust than that of clorgyline (2,8,36,45).…”

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confidence: 99%

“…It should be noted that almost all these investigations examined the effects of psychoactive drugs on animals such as golden hamsters or laboratory rats that have "normal" circadian rhythms rather than "abnormal" rhythms that might be more representative of clinical depression. To my knowledge, there is only one study that demonstrates how chronic antidepressant administration can reestablish a normal phase position in animals with a phase-advanced activity rhythm caused by complete social isolation (13).…”

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confidence: 99%

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Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats

Wollnik

1992

Pharmacology Biochemistry and Behavior

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WOLLNIK, F. E;ffects of chronic administration and Withdrawal of antidepressant agents on circadian activity rhythms in rats.PHARMACOL BIOCHEM BEHAV 43{2) S49-S61, 1992.-Experimental and clinical studies indicate that clinical depression may be associated with disturbances of circadian rhythms. To explore the interaction between circadian rhythmicity, behavioral state, and monoaminergic systems, the present study investigated the effects of chronic administration and withdrawal of the following antidepressant agents on circadian wheel-running rhythms of laboratory rats: a) moclobemide, a reversible and selective monoamine oxidase (MAO) type A inhibitor; b) Ro 19-6327, a selective MAO type B inhibitor; c) desipramine, a preferential norepinephrine reuptalce inhibitor; d) clomipramine and e) fluoxetine, both serotonin reuptake inhibitors; and f) levoprotillne, an atypical antidepressant whose biochemical mechanism is still unknown. Wheel-running activity rhythms were studied in three inbred strains of laboratory rats (ACI, BH, LEW) under constant darkness (DD). Two of these inbred strains (BH and LEW) show proround abnormalities in their circadian activity rhythms, namely, a reduced overall level of activity and bimodal or multimodal activity patterns. Chronic treatment with moclobemide and desipramine consistently increased the overall level, as well as the circadian amplitude, of the activity rhythm. Furthermore, the abnormal activity pattern of the LEW strain was changed into a unimodal activity pattern like that of other laboratory rats. The free-running period r was slightly shortened by moclobemide and dramatically shonened by desipramine. Effects of moclobemide and desipramine treatment on overall activity level and duration were reversed shortly after termination of treatment, whereas long aftereffects were observed for the free-running period. All other substances tested had no systematic effects on the activity rhythms of any of the strains. The fact that moclobemide and desipramine altered the period, amplitude, and pattern of circadian activity rhythms is consistent with the hypothesis that monoaminergic transmitters play a significant role in the neuronal control of behavioral state and circadian rhythmicity. Although the present study found that some antidepressives affect parameters of circadian rhythmicity, it could not demonstrate a common effect of all classes of antidepressives. Circadian rhythmsGenetic differences Inbred strains Antidepressives Moclobemide Ro 19-6327 Desipramine Clomipramine Fluoxetine Levoprotiline IT has often been suggested that there is an association between the pathophysiology of affective disorders and disturbances of circadian rhythms. For example, studies in humans have shown that affective disorders are associated with abnormalities in the period, phase, and/or amplitude of physiological, behavioral, and endocrine rhythms, resulting in quite a number of different hypotheses on the chronobiology of depression (16,18,20,39,41). Special attention has been paid to the ob...

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Section: Discussionmentioning

confidence: 85%

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confidence: 99%

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confidence: 99%

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Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats

Wollnik

1992

Pharmacology Biochemistry and Behavior

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“…The inability of neonatal clomipramine-treated hamsters to exhibit day-night differences in anxiety-related behavior suggests that the circadian component of behavior is altered in these animals. Disarrayed circadian rhythms were reported in other experimental models of depression [36][37][38] and rats neonatally treated with clomipramine reportedly showed an increased amplitude in their drinking activity rhythm [25]. On the other hand, a decreased amplitude of rhythms, including amplitude of sleep and temperature rhythms, was found in depressed patients [3].…”

Section: Discussionmentioning

confidence: 95%

Effects of Neonatal Clomipramine Treatment on Locomotor Activity, Anxiety-Related Behavior and Serotonin Turnover in Syrian Hamsters

Yannielli¹,

Kargieman²,

Gregoretti³

et al. 1999

Neuropsychobiology

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Day-night differences in locomotor and anxiety-related behavior and brain serotonin metabolism were examined in adult Syrian hamsters that received clomipramine (15 mg/kg) or vehicle from day 8 to day 21 of life. Locomotor activity was significantly greater at the beginning of scotophase (20.00 h) than at noon (12.00 h) and it was highest in hamsters treated with clomipramine at both examined times. Significant day-night differences in anxiety-related behavior, as measured in a plus-maze paradigm, were found in saline-treated hamsters only, with higher values at night. Clomipramine-treated hamsters exhibited augmented 5-hydroxyindoleacetic acid/serotonin ratio in hypothalamus and midbrain raphe, while serotonin content decreased in frontal cortex and hypothalamic areas. The results indicate that neonatal clomipramine treatment produces a long-lasting change in locomotion and anxiety-related behavior, as well as reduces brain serotonin content in hamsters.

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“…Abnormalities in the behavioral response of isolated rats to distinct challenges have been associated with functional changes in the endocrine response, although differences in social isolation procedures or test environments among studies have led to apparently discrepant results. For example, the basal level of corticosterone in plasma was found to be either unchanged (Morinan and Leonard 1980;Viveros et al 1988;Haller and Halàsz 1999), increased (Rivier and Vale 1987;Greco et al 1990;Genaro et al 2004;Sandstrom and Hart 2005) or decreased (Miachon et al 1993;Sanchez et al 1998;Chida et al 2005) in socially isolated animals.…”

Section: Discussionmentioning

confidence: 96%

Social isolation-induced changes in the hypothalamic–pituitary–adrenal axis in the rat

Serra

Pisu

Floris³

et al. 2005

Stress

118

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Social isolation of rats both reduces the cerebrocortical and plasma concentrations of 3a-hydroxy-5a-pregnan-20-one (3a,5a-TH PROG) and 3a,5a-tetrahydrodeoxycorticosterone and potentiates the positive effects of acute stress and ethanol on the concentrations of these neuroactive steroids. We now show that social isolation decreased the plasma level of adrenocorticotropin (ACTH), moreover, intracerebroventricular administration of corticotropin releasing factor (CRF) induced a marked increase in the plasma corticosterone level in both isolated and group-housed rats, but this effect was significantly greater in the isolated rats (+121%) than in the group-housed rats (+86%). In addition, in isolated rats, a low dose of dexamethasone had no effect on the plasma corticosterone concentration, whereas, a high dose significantly reduced it; both doses of dexamethasone reduced plasma corticosterone in group-housed rats. Furthermore, the corticosterone level after injection of dexamethasone at the high dose was significantly greater in the isolated animals than in the group-housed rats. These results suggest that social isolation increased sensitivity of the pituitary to CRF and impaired negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis.

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Chronic administration of imipramine antagonizes deranged circadian rhythm phases in individually housed rats

Cited by 15 publications

References 9 publications

Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats

Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats

Effects of Neonatal Clomipramine Treatment on Locomotor Activity, Anxiety-Related Behavior and Serotonin Turnover in Syrian Hamsters

Social isolation-induced changes in the hypothalamic–pituitary–adrenal axis in the rat

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