Social isolation-induced changes in the hypothalamic–pituitary–adrenal axis in the rat

Serra, Mariangela; Pisu, Maria Giuseppina; Floris, Ivan; Biggio, Giovanni

doi:10.1080/10253890500495244

Cited by 118 publications

(83 citation statements)

References 43 publications

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“…Following the activation of the HPA axis, the anterior pituitary secretes ACTH and the adrenal cortex secretes Cor in a few minutes to affect the behavior and neuroendocrine activities associated with the stress. Therefore, ACTH and Cor are often considered as the most classic and important indicators in studying stress (16,17). In the present study, the serum ACTH and Cor levels increased in the HE group, which indicated that the HPA axis of rats was activated in the process of exposure.…”

Section: Discussionsupporting

confidence: 53%

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats

et al. 2015

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Abstract. The aim of the present study was to investigate the effect of acute heat stress on the neuroendocrine and immunological function in rats. Male Sprague-Dawley rats were randomly divided into two groups and respectively exposed to heat (32˚C) or to room temperature (24˚C). After 7 days of heat exposure, the heat-stress rat model was established. The organ coefficients of the pituitary and adrenal glands were determined. The body temperature was measured by telemetry. The average contents of adrenocorticotropic hormone (ACTH), cortisol (Cor), interleukin-2 (IL-2) and IL-12 in serum were detected. The expression of apoptotic genes in the spleen was measured. The results showed that acute heat stress did not evidently affect the body temperature and body weight (P>0.05), but the exposure increased the organ coefficients of the pituitary and adrenal glands (P<0.05). Heat exposure significantly elevated the level of ACTH, Cor, IL-2 and IL-12 (P<0.05). The expression of caspase-3 and Bax were not changed significantly (P>0.05), while Bcl2 was reduced (P<0.05).

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Section: Discussionsupporting

confidence: 53%

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats

et al. 2015

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“…Similar to abuse-prone HR rats, described earlier, isolated animals have an overactive stress axis (Serra et al, 2005). Basal corticosterone is higher in IC than in EC rats, and the amphetamine-stimulated increase in corticosterone is greater in IC rats (Stairs et al, 2011).…”

Section: Psychosocial Influences and Abused Drugsmentioning

confidence: 61%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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“…On the other hand, a single injection of Aβ1-42 (25 pmol/rat) into the hippocampal dentate gyrus of rats transiently induces cognitive decline without appreciable changes in behavior and locomotor activity , suggesting that the dose of Aβ1-42 and its injection site is critical for Aβ1-42 pathophysiology. Social isolation changes the HPA axis activity in the experimental animals (Serra et al, 2005), followed by behavioral abnormality such as aggression (Blanchard et al, 2001;Backström and Winberg, 2013). BPSD-like symptoms may be facilitated by social isolation in Aβ1-42-injected adult mice.…”

Section: Discussionmentioning

confidence: 99%

Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia

et al. 2016

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-In patients with Alzheimer's disease, in addition to the core symptoms, i.e., cognitive dysfunction, behavioral and psychological symptoms of dementia (BPSD) such as aggression, anxiety, and hallucinations are known to occur frequently. Because various environmental factors influence the onset and progression of Alzheimer's disease, in the present study, BPSD-like behavioral abnormality of Amyloid β (Aβ)1-42-injected mice was assessed under social isolation, which induces behavioral abnormality. Aβ protein (500 pmol) was injected into the lateral ventricle of mice, which were individually housed. Two and three weeks after injection into adult mice, the rate of mice that exhibited aggressive behavior, i.e., biting attacks and wrestling, to the total mice, was markedly increased by Aβ injection. Aβ-injected adult mice also showed anxiety-like behavior, in addition to cognitive decline. Serum corticosterone level was markedly increased by Aβ injection. When excitability of hippocampal neurons was checked using hippocampal slices, KCl-induced presynaptic activity was enhanced in hippocampal slices prepared from Aβ-injected mice. These results suggest that social isolation housing of Aβ1-42-injected adult mice induces BPSD-like behavioral abnormality in addition to cognitive decline. It is likely that behavioral abnormality of Aβ1-42-injected adult mice is associated with excitability of hippocampal glutamatergic neurons, which is associated with the elevated corticosterone level.

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Social isolation-induced changes in the hypothalamic–pituitary–adrenal axis in the rat

Cited by 118 publications

References 43 publications

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia

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