Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats

Gamoh, Shuji; Hashimoto, Michio; Sugioka, Kozo; Hossain, Shahdat; Hata, Noriaki; Misawa, Yoshihisa; Masumura, Sumio

doi:10.1016/s0306-4522(99)00107-4

Cited by 270 publications

(201 citation statements)

References 36 publications

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“…We observed that DHA content of brain phospholipids in the n-3 enriched group, i.e., the group fed with an enteral feeding formula containing alpha-linolenic acid, was signifi cantly higher than that in the conventional group fed with a formula lacking n-3 PUFAs. These results confirmed the results of previous studies on rats fed with a diet defi cient in n-3 PUFAs for 3 generations 13 . Moreover, n-6 DPA, which is suggested to increase when the diet is defi cient in n-3 PUFAs, could be detected in the brain, liver, and RBCs of the conventional group only.…”

Section: Discussionsupporting

confidence: 82%

“…In the case where rats were fed an n-3 PUFA lacking diet for 3 generations, the administration of DHA for 10 weeks increased DHA levels in the cerebral cortex and hippocampus 13 . Although brain homeostasis is robust in general and is rarely affected by diet, the fatty acid composition in the brain is affected when there are extreme variations in the fatty acid composition of the diet and when DHA is admin- Data are mean SE (n=10) Signifi cantly different from the conventional group at *p<0.05, **p<0.01.…”

Section: Discussionmentioning

confidence: 99%

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Long-term Effect of an Enteral Diet with a Different n-6/n-3 Ratio on Fatty Acid Composition and Blood Parameters in Rats

et al. 2011

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Long-term Effect of an Enteral Diet with a Different n-6/n-3 Ratio on Fatty Acid Composition and Blood Parameters in Rats

et al. 2011

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“…Consumption of DHA during development [15] or by aged rats [16] can improve learning and memory, and chronic administration of either the uridine source UMP, or especially, of DHA, can increase brain phosphatide levels [14].…”

Section: Introductionmentioning

confidence: 99%

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Holguin

Huang

Liu

et al. 2008

Behavioural Brain Research

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Living in an enriched environment (EC) during development enhances memory function in adulthood; living in an impoverished environment (IC) impairs memory function. Compounds previously demonstrated to improve memory among IC rats include CDP-choline and uridine monophosphate (UMP). Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDPcholine. It also uses the polyunsaturated fatty acid (PUFA) DHA, a precursor for the diacylglycerol incorporated into PC. DHA administration also improves cognition in young and aged rodents and humans; its effects on cognitively-impaired IC rats have not been characterized. We have thus examined the consequences of administering DHA (300 mg/kg ) by gavage, UMP (0.5% in the diet), or both compounds on hippocampal-and striatal-dependent forms of memory among rats exposed to EC or IC conditions for 1 month starting at weaning, and consuming a choline-containing diet. We observe that giving IC rats either dietary UMP or gavaged DHA improves performance on the hidden version of the Morris water maze (all P<0.05), a hippocampal-dependent task; coadministration of both phosphatide precursors further enhances the IC rats' performance on this task (P<0.001). Neither UMP, DHA, nor both compounds affects the performance of EC rats on the hidden version of the Morris water maze (P>0.05), nor the performance by IC or EC rats on the visible version of the Morris water maze (all P>0.05), a striatal-dependent task. We confirm that coadministration of UMP and DHA to rats increases brain levels of the phosphatides PC, PE, SM, PS, PI, and total brain phospholipid levels (all p<0.05), and show that rearing animals in an enriched environment also elevates brain PC, PS, and PI levels (all p<0.01) and total brain phospholipids (p<0.01) compared with their levels in animals reared in an IC environment. These findings suggest that giving DHA plus UMP can ameliorate memory deficits associated with rearing under impoverished conditions, and that this effect may be mediated in part through enhanced synthesis of brain membrane phosphatides.

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“…As a result, emotional behavior (depressivelike symptoms and anxiety) as well as learning and memory are impaired as shown by us and others (Fedorova and Salem, 2006;Lafourcade et al, 2011;Moranis et al, 2011). On the opposite, positive effects of diet enriched in DHA on learning and memory have been demonstrated in laboratory animals (Gamoh et al, 1999;Yehuda et al, 1999;Carrie et al, 2002). During aging, the level and replacement of brain PUFAs decreases, particularly in the hippocampus, cortex, striatum and hypothalamus (figure 3).…”

Section: Consequences Of the Decrease In N-3 Pufas On Age-related Neumentioning

confidence: 96%

Neuroinflammation and aging: influence of dietary n-3 polyunsaturated fatty acid

Layé

Delpech

Smedt-Peyrusse

et al. 2011

OCL

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Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats

Cited by 270 publications

References 36 publications

Long-term Effect of an Enteral Diet with a Different n-6/n-3 Ratio on Fatty Acid Composition and Blood Parameters in Rats

Long-term Effect of an Enteral Diet with a Different n-6/n-3 Ratio on Fatty Acid Composition and Blood Parameters in Rats

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Neuroinflammation and aging: influence of dietary n-3 polyunsaturated fatty acid

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