Neuroinflammation and aging: influence of dietary n-3 polyunsaturated fatty acid

Layé, Sophie; Delpech, Jean-Christophe; Smedt-Peyrusse, Véronique de; Joffre, Corinne; Larrieu, Thomas; Madore, Charlotte; Nadjar, Agnès; Capuron, Lucile

doi:10.1051/ocl.2011.0412

Cited by 5 publications

(3 citation statements)

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“…Numerous studies have also shown that consuming diets deficient in 3 fatty acids will impair cognitive functioning [24]. But the role of PUFAs needs to be better characterized by multidisciplinary studies aimed at assessing the effects of these molecules at different levels, from the molecular level to that of the organism as a whole [25].…”

Section: Consuming Monounsaturated Fatty Acids Andmentioning

confidence: 99%

Nutrition, Neuroinflammation and Cognition

Mandalika¹,

Vaidya²

2015

J. Nutr. Ther.

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Activation of microglia and astrocytes leads to the production of cytokines and other inflammatory mediators which may contribute to the apoptotic cell death of neurons observed in many neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Vulnerability of the central nervous system (CNS) to oxidative and inflammatory stress increases with age and has been postulated to be a leading contributing factor to the cognitive impairment and thereby development of neurodegenerative diseases. Suppression of microglial production of neurotoxic mediators may result in neuroprotection. This heightens the interest in the development of neuroinflammation-targeted therapeutics. Nutrition is involved in the pathogenesis of age-related cognitive decline and also neurodegenerative diseases. Certain nutrients facilitate human brain function with their immediate and long term effects. On the other hand, malnutrition influences the brain throughout life, with profound implications on cognitive decline and dementia. Several phytochemicals with potent antioxidant and anti-inflammatory activities, have been shown to repress microglial activation and exert neuroprotective effects. Thus this review highlights the role of foods, nutrients and phytochemicals in suppressing neuro-inflammation and also enhancing cognition.

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Section: Consuming Monounsaturated Fatty Acids Andmentioning

confidence: 99%

Nutrition, Neuroinflammation and Cognition

Mandalika¹,

Vaidya²

2015

J. Nutr. Ther.

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“…Moreover, these changes in immune functions may promote neurological disorders. As an example, the existence of a pro-inflammatory status in senior population, which includes also neuroinflammation (Layé et al, 2011), may lead to cognitive decline and neurodegenerative diseases (Wyss-Coray, 2016). This potential primary role of inflammation in different age-related diseases has led to the proposal of the 'inflammaging' theory (Franceschi et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Microbiome: Effects of Ageing and Diet

Salazar

González

Nogacka

et al. 2020

Current Issues in Molecular Biology

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The microbial community inhabiting our intestine, known as 'microbiota', and the ensemble of their genomes (microbiome) regulate important functions of the host, being essential for health maintenance. The recent development of next-generation sequencing (NGS) methods has greatly facilitated the study of the microbiota and has contributed to evidence of the strong influence exerted by age and diet. However, the precise way in which the diet and its components modify the functionality of the intestinal microbiome is far from being completely known. Changes in the intestinal microbiota occur during ageing, frequently accompanied by physiological changes of the digestive tract, modification of dietary patterns and impairment of the immune system. Establishing nutritional strategies aiming to counterbalance the specific alterations taking place in the microbiota during ageing would contribute to improved health status in the elderly. This review will analyse changes appearing in the intestinal microbiota from adulthood to old age and their association with dietary patterns and lifestyle factors.

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“…In turn, Tyr serves as the substrate for the enzyme Tyr hydroxylase, the rate‐limiting step in catecholamine (DA and NE) synthesis, as illustrated in Figure (McKean, ). However, upon immune activation or increased oxidative stress, alterations in the metabolism of Tyr may rely on the activation of the guanosine triphosphatecyclohydrolase‐1 (GTP‐CH1) pathway where GTP is converted to tetrahydrobiopterin (BH4) via de novo synthesis (Figure ; Capuron et al, ; Layé et al, ). The initial reaction is the conversion of GTP to 7,8‐dihydroneopterin‐triphosphate via GTP‐CH1 which is the rate‐limiting enzyme for BH4 biosynthesis (Capuron et al, ).…”

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confidence: 99%

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

et al. 2017

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Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants. Ambulatory blood pressure (BP) was monitored for 24 h, whereas carotid intima media thickness (CIMT) and cross-sectional wall area (CSWA) were determined ultrasonically. Essential amino acids were analyzed with a liquid chromatography tandem mass spectrometry method. Oxidative-inflammatory markers were measured by spectrophotometry. African men had poorer health than Caucasian men, including higher alcohol abuse, elevated BP, abdominal obesity, physical inactivity, and elevated inflammation. Phe (p < .001) and Phe/Tyr ratio (p = .006) as well as CIMT (p = .032) were higher in African men. DefS African men had higher levels of Phe (p = .002) and Phe/Tyr (p = .009) compared to DefS Caucasian men; these differences were not observed in non-DefS men. Systolic BP and inflammation (C-reactive protein) were positively associated with left (L-) CSWA, while Phe/Tyr was negatively associated with L-CSWA in DefS African men. African males presented with elevated Phe and Phe/Tyr ratio, catecholamine precursors, worsening during DefS-possibly driven by inflammation and BP contributing to structural vascular abnormalities.

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Neuroinflammation and aging: influence of dietary n-3 polyunsaturated fatty acid

Cited by 5 publications

References 40 publications

Nutrition, Neuroinflammation and Cognition

Nutrition, Neuroinflammation and Cognition

Microbiome: Effects of Ageing and Diet

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

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