Chronic Administration of Aqueous Extract ofHibiscus sabdariffa. Enhances Na+-K+-ATPase and Ca2+-Mg2+-ATPase Activities of Rat Heart

Olatunji, Lawrence Aderemi; Adebayo, Joseph O.; Adesokan, AA; Olatunji, Victoria A.; Soladoye, Ayodele O.

doi:10.1080/13880200600686129

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…The resulting homogenates were diluted appropriately with 0.25 M ice-cold sucrose solution (1:5, w = v) and kept frozen overnight [31]. The cardiac weight index (HW = BW) was calculated as previously reported [32].…”

Section: Methodsmentioning

confidence: 99%

Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

et al. 2019

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Cardiovascular diseases are major causes of non-communicable diseases (NCDs)-related throughout the world. Water pollution has been linked with the high global NCD burden but no report exists on the cardiotoxicity of untreated or poorly treated pharmaceutical effluent, despite its indiscriminate discharge into the aquatic environment in Nigeria, as in many other locations of the world. Thus, this study investigated the cardiotoxic effect of oral exposure to pharmaceutical effluent in mice. Thirty (30) male mice ( Mus musculus ) were randomly divided into 6 groups. Group A (control) received 0.2 ml distilled water, while groups B-F were treated with 0.2 ml 2.5%, 5.0%, 10.0%, 20.0% and 40% concentrations (v/v, effluent/distilled water) of the effluent respectively, for 28 days. Significant reductions ( p< 0.05) in heart weight and cardiac weight index were observed in the groups treated with 5%, 10%, 20% and 40% concentrations of the effluent, without significant change in body weight. Similarly, 28 day administration of the effluent showed significant decrease in cardiac Na + -K + -ATPase activity ( p< 0.05) at concentrations 10% and above, in a concentration dependent manner. However, there was insignificant decrease in cardiac Ca 2+ -Mg 2+ -ATPase activity of the exposed mice, when compared with the control group. This study provides novel information on the cardiotoxic effects of oral exposure to untreated pharmaceutical effluent, showing reduced Na + -K + -ATPase activity and decreseased myocardial atrophy. Therefore, drinking water contaminated with pharmaceutical effluent may promote the incidence of cardiovascular diseases. Further studies on the exact mechanistic routes of the induced cardiotoxicity are recommended.

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Section: Methodsmentioning

confidence: 99%

Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

et al. 2019

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“…28 Anthocyanin pigments and other phenolic compounds (Hibiscus protocatechuic acid) also isolated from dried flowers of H. sabdariffa demonstrated protective effects against tert-butyl hydroperoxide-induced oxidative damage and hepatotoxicity both in vitro and in vivo. 22,29 The aqueous extract was found to be effective against Ascaris galliavium in poultry.…”

Section: +mentioning

confidence: 99%

Determination of Antimicrobial Activity of Sorrel (Hibiscus sabdariffa) onEsherichia coliO157:H7 Isolated from Food, Veterinary, and Clinical Samples

Fullerton

Khatiwada

Johnson

et al. 2011

Journal of Medicinal Food

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The use of medicinal plants as natural antimicrobial agents is gaining popularity. Sorrel (Hibiscus sabdariffa) is widely used for the treatment of diseases. The objective of this study was to investigate the antimicrobial activity of sorrel on Escherichia coli O157:H7 isolates from food, veterinary, and clinical samples. Phenolics of the calyces were extracted from 10 g of ground, freeze-dried samples using 100 mL of 80% aqueous methanol. Concentrations of 10%, 5%, and 2.5% methanol extract of sorrel were investigated for its antimicrobial activity. Inhibition zones were indicated by a lack of microbial growth due to inhibitory concentrations of sorrel diffused into semisolid culture medium beneath the sorrelimpregnated disk. The results of this experiment showed that the most potent sorrel concentration was 10%, then 5%, and finally 2.5%. The overall mean zone of inhibition for the sorrel extract was 12.66 mm for 10%, 10.75 mm for 5%, and 8.9 mm for 2.5%. The highest inhibition zones (11.16 mm) were observed in veterinary samples, and the lowest (10.57 mm) in the food samples. There were significant (P < .05) differences among mean zones of inhibition found in the food, veterinary, and clinical sources. Based on the source of samples and concentration of sorrel extract, the lowest mean inhibition was 7.00 -0.04 mm from clinical samples, and the highest was 15.37 -0.61 mm from a food source. These findings indicated that sorrel was effective at all levels in inhibiting E. coli O157:H7; thus it possesses antimicrobial activity and hold great promise as an antimicrobial agent.

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“…Significant decrease of Na þ -K þ ATPase and Ca 2þ -ATPase showed abnormal energy metabolism of myocardial cells. [56][57][58] It was reported that long-term high-fat diet for 22 In the modeling rats, myocardial ischemia with abnormal energy metabolism led to an insufficient heart pump, resulting in the circulation disorders. Serum enzymes, such as ALP, ALT, and AST, would sensitively increase when liver cells are injured or necrotic.…”

Section: Discussionmentioning

confidence: 99%

An experimental model for hypertensive crises emergencies: Long-term high-fat diet followed by acute vasoconstriction stress on spontaneously hypertensive rats

Liu

Sui

Long

et al. 2018

Exp Biol Med (Maywood)

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Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0.8 mg/kg). Forty-four biochemical parameters were detected, covering hepatic and renal function, blood glucose and lipid levels, myocardial enzymes and energy metabolisms, blood coagulative and anti-coagulative system, oxidative stress and anti-inflammatory cytokine, blood viscosity, and RAAS system. Six tissues including heart, brain, liver, kidney, coronary arteries, and mesenteries were removed for pathological observations with hematoxylin-eosin staining. As a result, multi-organ dysfunctions in the heart, brain, liver, kidney, vascular endothelium, and blood system were testified in the modeling rats at weeks 6 and 8. In conclusion, severe consequences of this animal model were highly similar to those in hypertensive crises emergencies, which could be further utilized in the early intervention of hypertensive crises emergencies including the possible risk factors control and efficient therapies assessment. Impact statement In the late 90s, numerous reports predicted that 1-2% of hypertensive individuals would undergo hypertensive crises (HPC) and figures reached as high as 7% when no antihypertensive therapies were administrated. Currently, clinical failures appear frequently due to the improper or excessive medication regimen instead of the illness itself. Therefore, early evaluations and observations of HPC on appropriate animal models ahead of patients should be discussed and emphasized more widely. In the present study, an appropriate animal model for HPC emergencies was firstly established, in which the consequences of long-term high-fat diet feeding followed by an acute vasoconstriction stress on the spontaneously hypertensive rats were experimentally testified. The proposed model would have a wide application prospects in early intervention of HPC emergencies including the controls of possible risk factors and assessments of efficient therapies.

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Chronic Administration of Aqueous Extract ofHibiscus sabdariffa. Enhances Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase Activities of Rat Heart

Cited by 12 publications

References 14 publications

Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

Determination of Antimicrobial Activity of Sorrel (Hibiscus sabdariffa) onEsherichia coliO157:H7 Isolated from Food, Veterinary, and Clinical Samples

An experimental model for hypertensive crises emergencies: Long-term high-fat diet followed by acute vasoconstriction stress on spontaneously hypertensive rats

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