Chronic administration of aluminum–fluoride or sodium–fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity

Varner, Julie; Jensen, Karl F.; Horvath, William J.; Isaacson, Robert L.

doi:10.1016/s0006-8993(97)01336-x

Cited by 152 publications

(107 citation statements)

References 67 publications

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“…Al appears to synergistically enhance the neurotoxic hazards caused by fluoride [258][259][260][261]. In studies on Methanosarcina thermophila by Miles et al, aluminum fluoride in the form of AlF 3 or AlF 4 − was proposed to mimic the phosphoryl group in the catalytic transition state of acetate kinase [262][263][264].…”

Section: Induction Of Oxidative Genotoxic and Protein Conformationamentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

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This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

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Section: Induction Of Oxidative Genotoxic and Protein Conformationamentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

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“…However, there exist some implications for the combined effects of aluminum with fluoride even at such low levels (Verner et al, 1998).…”

Section: Aluminummentioning

confidence: 99%

Evaluation of quality of drinking water from Baghdad, Iraq

Barbooti¹,

Bolzoni²,

Mirza³

et al. 2010

Science World Journal

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This is a joint work between the Italian Red Cross and the Environmental Laboratories, Baghdad. The drinking water (DW) samples from 16 residential districts in Baghdad were chemically evaluated with reference to the raw water samples and water directly taken from the purification plants. In addition to the routinely measured parameters, 17 metals and 11 trihalomathane (THM) were measured. Generally, the samples of water analysed can be considered of good quality. The relatively high sulphate and aluminium contents results from the use of aluminium sulphate as flocculent. The ammonia and Nitrite concentrations were lower than the detectable limit, because ammonia is converted into chloramines and nitrite is converted into Nitrate during chlorination. This indicates no sewage contamination of the drinking water. The high chloride contents can be referred to the use of partially degraded hypo for the disinfection. The presence of THM's in the samples analysed is indicative of good disinfection process. The presence of these compounds is preferred better than bacterial contamination. The relatively high levels of zinc and iron have no impact on the quality of DW. Iron, however, was efficiently removed during the treatment, together with Manganese. Reference was done to the EU specification of drinking water regarding total hardness, chloride contents, sulphate, iron and THM's. As for the iron content, the original pH of the river water (7.5 and 8.0) ensures that Iron should not be present in soluble form at a detectable level. Corrosion of the pipes could be one of the reasons for the presence of iron.

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“…The research on Fl and the brain that have been studied in humans in India, China, Iran, and Mexico showed that high levels of Fl exposure were associated with IQ deficits in children (NRC, 2006). The animal studies have also documented the considerable evidence on the direct toxic effects of Fl on the brain, even at the low level of 1 ppm Fl in water (Varner, Jensen, Horvath, & Isaacson, 1998). These effects include a reduction in nicotinic acetylcholine receptors, reduction in lipid content, impaired anti-oxidant defense, damage to the hippocampus, Purkinje cells and accumulation of Fl in the pineal gland and the formation of betaamyloid plaques (NRC, 2006).…”

Section: Introductionmentioning

confidence: 99%

A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Thangapandiyan

Abdulla

Yakulasamy

et al. 2018

JoBAZ

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Background: Fluoride (Fl) exposure engenders neurodegeneration and induces oxidative stress in the brain. Therefore, the mechanism of Fl-induced neurotoxic effects needs to be determined. The aim of this study was to investigate the neuroprotective effects of EGCG (40 mg/kg) on Fl (25 mg/kg/bw)-induced oxidative stress mediated neurotoxicity with special emphasis on the hippocampus (4 weeks).Results: Fl-intoxicated rat shows an increased Fl concentration along with the decreased neurotransmitter (AChE, NP, DA and 5-HT) activity in the brain. The oxidative stress markers (ROS, TBARS, NO, and PC) was significantly increased with decreased enzymatic (SOD, CAT, GPx, GR, GST, and G6PD) and nonenzymatic antioxidants (GSH, TSH, and Vit.C) in the rat hippocampus. Moreover, results showed that increases in intrinsic and extrinsic apoptotic pathway leading to DNA damage and cell death were also proved by the immunohistochemical, histological, and ultra-structural studies in the Fl-treated rat hippocampus. In this context, pre-administration of EGCG significantly improved the oxidative stress, biochemical changes, cellular apoptotic and histological alternations by Fl in the hippocampus of rats. Conclusions: These results confirmed the EGCG supplementation might attenuate the Fl-induced neurotoxicity via Nrf2/Keap1 signaling pathway in the rat hippocampus.

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Chronic administration of aluminum–fluoride or sodium–fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity

Cited by 152 publications

References 67 publications

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Evaluation of quality of drinking water from Baghdad, Iraq

A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

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