A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Thangapandiyan, S.; Abdulla, Sharmilabanu; Yakulasamy, Vadivazhagi; Miltonprabu, Selvaraj; Ramesh, Mathan

doi:10.1186/s41936-018-0020-z

Cited by 25 publications

(9 citation statements)

References 53 publications

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“…Epigallocatechin gallate (EGCG) found in tea, particularly green tea, is a flavonoid characterized by very string antioxidative properties. A study revealed a very significant increase in the enzymatic and non-enzymatic antioxidative properties as well as a decrease of oxidative stress indicators in the brains of rats poisoned with NaF after a 4-week application of EGCG [92]. Numerous other studies available in the literature confirm the positive effects of green tea in cases of oxidative stress in the brains of laboratory animals poisoned with prooxidative substances ( Table 2).…”

Section: Phenolic Compoundsmentioning

confidence: 85%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' general condition. One of the main problems related to the treatment of this type of condition is the limited ability to deliver drugs to the brain due to their poor solubility, low bioavailability, and the effects of the blood-brain barrier. Given the above, one of the main objectives of contemporary scientific research focuses on the prevention of neurodegenerative diseases. As disorders related to the competence of the antioxidative system are a marker in all diseases of this type, the primary prophylactics should entail the use of exogenous antioxidants, particularly ones that can be used over extended periods, regardless of the patient's age, and that are easily available, e.g., as part of a diet or as diet supplements. The paper analyzes the significance of the oxidoreductive balance in the pathogenesis of neurodegenerative diseases. Based on information published globally in the last 10 years, an analysis is also provided with regard to the impact of exogenous antioxidants on brain functions with respect to the prevention of this type of diseases.

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Section: Phenolic Compoundsmentioning

confidence: 85%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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“…Sodium fluoride-induced neurotoxicity in rats prevented by EGCG. Utilizing EGCG decreased ROS, TBARS, NO, and protein carbonylation levels, augmented GSH, TSH, and vitamin C activities, increased SOD, CAT, GPX, GST, GR, and G6PD activities, reduced TNF-α, NF-kB, and Fas mRNA expression, declined Bad and Bax, elevated Bcl-2 mRNA expression, attenuated caspase 3, caspase 8, and caspase 9 gene and protein expressions, protected DNA damage, and Nrf2/Keap might be involved (Shanmugam et al, 2018). 1-Methyl-4-phenyl-pyridinium induced neuronal damage in PC12 cells.…”

Section: Neurotoxicitymentioning

confidence: 99%

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Talebi

Farkhondeh

et al. 2021

Phytotherapy Research

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Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes mellitus, renal injuries, respiratory conditions, gastrointestinal disturbances, and general disorders related to oxidative stress, inflammation, apoptosis, gelatinolysis, autophagy, and fibrogenesis processes. Green tea catechins as a rich source of phenolic compounds can deal with various clinical problems and manifestations. In this review, we attempted to focus on intervention between green tea catechins and Nrf2. Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap-1, HO-1, NQO-1, GPx, GCLc, GCLm, NF-kB cross-link, kinases, and apoptotic proteins. Subsequently, we compiled an updated expansions of the Nrf2 role as a gate to manage and protect different disorders and feasible indications of green tea catechins through this signaling pathway. The present review highlighted recent evidence-based data in silico, in vitro, and in vivo studies on an outline for future clinical trials.cancer, catechins, epigallocatechin gallate (EGCG), green tea, nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway, oxidative stress, therapeutic effects | INTRODUCTIONEvidence-based researches have indicated that existing phytochemicals in various natural agents serve as protectants or therapeutics with the possession of benefits such as high therapeutic index, low cost, and feasible availability (Leitzmann, 2016). Green tea is a well-known and popular beverage that has been used in a great proportion of the universe's population. Catechins are major polyphenols of green tea most commonly used and have responsibility for its therapeutic applications. Efficacy of green tea catechins combat malignancies and numerous neoplasms, cardiovascular diseases and metabolic syndrome, neurodegeneration, autoimmune complications, kidney and urinary tract obstructions, respiratory tract ailments, digestive system dysfunctions, toxicities, microbial diseases, and oxidative damages have been confirmed in recent studies (Mak, 2012;Zaveri, 2006).Besides the effective roles of polyphenols in the alleviation of mortality and morbidity rates have been proved. In some conditions, dysfunctionalities do not prognoses through utilizing conventional drugs and other routes of treatment may be invasive. Therefore, consuming worthful nutraceuticals such as green tea catechins with their

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“…Consistent with this finding, several studies have observed that NO inhibits the molecular activity of renal NKA [232,313,316,317,318,319]. Several studies have also shown that F − induces NO synthesis in vivo [320,321,322,323,324,325,326]. Furthermore, experimental studies have shown that F − stimulates cGMP in the kidney and thyroid [327,328].…”

Section: Molecular Mechanisms By Which Fluoride Inhibits Na+ K+-amentioning

confidence: 69%

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neuropeptides and cytokines, as well as biological interface interactions that rely on the bioavailability of chemical elements magnesium and manganese to modulate ATP and Na + , K + -ATPase enzyme activity. Taken together, the findings of this study provide unprecedented insights into the molecular mechanisms and biological pathways by which F inhibits Na + , K + -ATPase activity and contributes to the etiology and pathophysiology of diseases associated with impairment of this essential enzyme. Moreover, the findings of this study further suggest that there are windows of susceptibility over the life course where chronic F exposure in pregnancy and early infancy may impair Na + , K + -ATPase activity with both short- and long-term implications for disease and inequalities in health. These findings would warrant considerable attention and potential intervention, not to mention additional research on the potential effects of F intake in contributing to chronic disease.

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A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Cited by 25 publications

References 53 publications

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

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