Chronic adenohypophysitis in a rhesus monkey immunised with extracts of human placenta

Novel autoantigens in autoimmune hypophysitis

“…Beck and Melvin were, in fact, capable of inducing experimental hypophysitis in one female rhesus monkey by injecting her with human placental extracts and chorionic somatomammotrophin. 35 The five pituitary enzymes revealed by our mass spectrometry sequencing are ubiquitous and not pituitary specific. It is seemingly difficult to reconcile how a ubiquitous antigen could be implicated in the pathogenesis of an organ-specific autoimmune disease such as hypophysitis.…”

“…Notably, there is circumstantial evidence that CSH can indeed be a true pathogenic autoantigen in hypophysitis. Beck and Melvin were, in fact, capable of inducing experimental hypophysitis in one female rhesus monkey by injecting her with human placental extracts and chorionic somatomammotrophin 35 …”