Chromosomes in a Case of Pure Gonadal Dysgenesis

Abstract

These results suggest that the same method might be used against these flies, but it is first necessary to discover the stage of the insect's development at which it is most susceptible to sterilization. This entails working in a laboratory with insect pupae of known age, as near as possible to a good supply of tsetse flies, and the Colonial Pesticides Research Unit at Arusha will undertake this research.

Steroid Synthesis in Vitro by Tumour Tissue From a Dysgenetic Gonad

“…This is of interest, since they are normally found in individuals with a female phenotype but abnormal karyotypes involving sex chromosomes, such as the 46/XO of Turner's syndrome (Jones, Ferguson-Smith & Heller, 1963). That streak gonads are found in patients showing sexual abnormalities, but normal male 46/XY or female 46/XX karyotypes as in the syndrome of gonadal dysgenesis (Harnden & Stewart, 1959) implies that in such cases, if there is a genetic abnormality, it is minor and is not detected by a relatively crude examination of chromosomes at metaphase, or that there may be an undetected gonadal mosaicism. Virilism, in the form of clitoral hypertrophy, may, or may not, be one of the signs of gonadal dysgenesis.…”

Sex Chromatin and Chromosomes in Man

“…Rather it is the absence of functional testes. 37 That the mere presence of testes is insufficient to direct development along masculine lines is emphasized by the situation in the syndrome of testicular feminization which will be discussed later in this paper.…”

Two Cases of Gonadal Dysgenesis with Typical Female Chromosomal Pattern

“…We excluded further from this table cases in which the diagnosis was made on the basis of culdoscopy alone [1,3], or w ithout any inspection of the streaks [7,10,22]. Buhner's [2] patient with ovarian dysgenesis who became pregnant, and Kinch's [30] patient with ovarian follicular dysgenesis are strong argum ents to postulate histological and genetic confirmation of the diagnosis.…”

“…Gonadal dysgenesis in patients with various phenotypes and a num ber of different chromosomal patterns has been reported: \ ( ) [10,15,16,35], XY [18,19,22], XX (Table I), X -X chromosome w ith presumed deletion of the long arm [10,18,19,20], XO /XX [10,20,31], X O /X X X [20], X O /X X /X X X [9,37], XO XY [10], AO XYY [10], XQ/X-isochroinosomc X [10]. This prompted Becker et al [4] to introduce the term " chromosomal spectrum of gonadal dysgenesis."…”