Chromosome Studies in Selected Spontaneous Abortions. Polyploidy in Man

Chromosome studies in selected spontaneous abortions. Polyploidy in man.

“…Triploid/diploid mosaicism is relatively rare among abortuses (Schlegel et al, 1966;Boue and Boue, 1970;Carr, 1970c). There have, however, been 6 reported cases of triploid/diploid mosaicism in living infants.…”

“…This may also apply to tetraploidy but there were too few specimens to be significant. Possible mechanisms have been discussed elsewhere (Carr, 1970c).…”

Three Further Cases of Triploidy in Man Surviving to Birth

“…The possible modes of origin and aetiology of triploidy in man have been discussed by several authors (Edwards et al, 1967;Schindler and Mikamo, 1970;Carr, 1971). There is evidence (Carr, 1970) that triploidy is increased among abortuses from women who became pregnant within six months of ceasing oral contraception.…”

“…Of the three cases reported here no information is available on case 1, but oral contraceptives had not been used in case 2 nor in case 3 except some six years previously, and then for only a brief period. The frequency of all triploid conceptuses has been estimated by Carr (1971) to be in the order of 1%), the majority of which apparently abort by the end of the first trimester. The live birth of a triploid infant is however now well documented and Edward et al (1967) have suggested that perhaps, at a maximum, 0-01%0' of births would be triploid.…”

ABO incompatibility as a cause of spontaneous abortion: evidence from abortuses.

“…In this respect a higher incidence of morphological and chromosomal anomalies, which could be lethal to the conceptuses, was observed in the compatible abortuses (18-6% versus 8-6%). We could not identify the blood type of the fetal placental tissues and, therefore, did not examine the cases of empty sac and growth disorganization which are well known to show very high incidence of chromosomal aberrations (Carr, 1971;Poland and Miller, 1971). In any event, on the basis of this study it seems reasonable to conclude that maternal-fetal ABO incompatibility plays a role as an aetiological factor in some cases of spontaneous abortion.…”