ABO incompatibility as a cause of spontaneous abortion: evidence from abortuses.

Takano, Kiichi; Miller, James R.

doi:10.1136/jmg.9.2.144

Cited by 36 publications

(15 citation statements)

References 14 publications

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“…When preterm delivery and abortion occur, the influence of individual and environmental factors is difficult to assess, but it can be reasonably assumed that genetic factors play an important role in these incidents (3,5). We know that at least four polymorphic genetic systems, i.e., ABO, Rh, haptoglobin, placental alkaline phosphatase, may intervene simultaneously in the selection process that takes place during early intrauterine developnlent and give rise to abortion, and possibly to preterm delivery and neonatal jaundice (5,13). Interactions between these systems can produce pathologic effects in the fetus and in the newborn which are still largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The molecular polymorphism of transferrin (Tf), the iron-binding p globulin of the human serum, has been extensively studied by the use of starch gel electrophoresis (9); subsequently, the isoelectric focusing technique has brought evidence of a greater microheterogenity of the most commonly encountered C allele: two transferrin suballeles can be detected with this technique, C, (anodal) and C2 (cathodal) (7,13,14) (Fig. 1).…”

Section: Speculationmentioning

confidence: 99%

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Transferrin C Subtypes in Extremely Premature Newborn Infants

et al. 1982

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SummaryGenetic typing of serum transferrin was performed in a group of 88 extremely premature infants (gestation age <32 wk) and in a control group of 351 full-term infants, using isoelectric focusing technique on ultrathin layer of polyacrilamide gel. A major incidence bf Cz type was found among the preterm infants when compared to full-term infants X2 = 22,86, (P < 0.001).In view of the previously reported higher incidence of this phenotype in women prone to spontaneous abortion, a selective mechanism associated with this serum transferrin type promoting spontaneous abortion and preterm delivery, seems to occur. The relative risk of preterm delivery were calculated to 1.4 and 8.3 for the Cz-l and Cz types, respectively. Supportive evidence in favour of this hv~othesis is offered bv the correlation existing between ".transferrin Cz allele and placeital alkaline phosphatase;ariant F, the latter being associated with increased risk of spontaneous abortion. SpeculationAssessment of the familial genetic pattern of serum transferrin may result to be a useful procedure for the evaluation of genetic risk of abortion and preterm delivery.The molecular polymorphism of transferrin (Tf), the iron-binding p globulin of the human serum, has been extensively studied by the use of starch gel electrophoresis (9); subsequently, the isoelectric focusing technique has brought evidence of a greater microheterogenity of the most commonly encountered C allele: two transferrin suballeles can be detected with this technique, C, (anodal) and C2 (cathodal) (7,13,14) (Fig. 1).Recently, the Tf suballele Cz was found to have a high incidence in women prone to spontaneous abortion: the relative risk of abortion was found to be 2.3, 1.4, 0.6 for the C2, C2-I, and C I subtypes, respectively (2). The aim of the present study was to investigate on the relationships existing between the transferrin C polymorphism and extremely premature delivery. MATERIALS AND METHODSWe have compared gene frequencies of the Tf C alleles in a group of 88 preterm infants (gestational age <32 wk) and a group of 35 1 term controls taken at random from population of healthy newborn delivered in the same period of time. About 40% of the infants of these two groups originated from the province of Rome, the remaining 60% from the province of Arezzo (Tuscany). It was ascertained that gene frequencies of the Tf alleles are identical in the two provinces and therefore computation was operated regardless of the place of origin.Cord serum samples were obtained at delivery and stored at -20°C before the determination. The informed consent was obtained from the parents.The gestational age was calculated on the basis of the date of the first day of the last menstrual period and on obstetric and neonatal objectivity (8). If discordance aroused between our estimation and that of the mother, the infant was excluded from the study.Four preterm infants were deliberately excluded from this study because preterm delivery was ascribed to specific causes, such as uterus malformation, ac...

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Section: Discussionmentioning

confidence: 99%

Section: Speculationmentioning

confidence: 99%

Transferrin C Subtypes in Extremely Premature Newborn Infants

et al. 1982

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“…Hiraizumi et al, (1970), Takano and Miller,(1972) and Ghasemi et al, (2011) showed ABO incompatibility also caused recurrent abortions and hemolytic disease.…”

Section: Introductionmentioning

confidence: 99%

ABO Blood Groups Compatibility and Incompatibility among Basrah Families

Hassan¹

2017

ijSciences

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Abstract:In the present study, 277 couples were randomly collected from Basra population who have at least two live births and below 60 years of age to study of ABO blood groups compatibility and incompatibility among Basra families. It has been shown that the incidence of compatible matings (51.625%) higher than incompatible matings (48.375%). The study has been revealed the spontaneous abortion and stillbirth were slightly higher in couples with incompatible (11.889%)(2.797%) as a compared with compatible couples (10.778%)(2.333). While the incidence of living births higher in compatible matings (86.889%) than incompatible matings (85.315%). study came to a conclusion that there is an increase in the number of spontaneous abortions and stillbirth among B wife and AB husband couples and followed by O wife and AB husband incompatible couples (35.294),(20.833%) respectively.

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“…The literature expanded greatly in the years since [see C o h en and Sayre, 7 for bibliography] but no clearly consistent rela tionships emerged until recently. Now, several clinical reports on the blood group distribution among abortuses [3,17,26] and epidemiological data on fetal loss by maternal type [7] have established that ABO incompatibility carries with it a substantially increased risk of fetal death.…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, even though it is now clear that such incompatibility does play a role in fetal mortality [3,17,26], other factors would necessarily seem to be responsible for the greater pregnancy wastage of A than of B women [7] and for the low sex ratio of A mothers' A children [2,6,19].…”

Section: Discussionmentioning

confidence: 99%