Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose.

Chapelle, Albert de la; Rekonen, A; Oka, Martti; Ruotsi, Ahti

doi:10.1136/ard.31.6.508

Cited by 69 publications

(23 citation statements)

References 8 publications

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“…The amount of leakage that has been reported after injection ranges from little or no leakage in the majority of patients, to as high as 70% (Rivard et al, 1994;Siegel et al, 1994;Gedik et al, 2004). Joint immobilisation after the procedure is an important measure to minimise leakage (Gratz et al, 1999;de la Chapelle et al, 1972).…”

Section: Radionucleotide Synovectomymentioning

confidence: 99%

Modern management of haemophilic arthropathy

2007

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SummaryCurrently available factor concentrates for treatment of patients with haemophilia are virally inactivated or are made by recombinant technology and their broad use in developed nations has resulted in the dramatic elimination of the treatment‐related viral illnesses that decimated the haemophilia community in the late 20th century. The major morbidity experienced by patients with haemophilia today is joint disease, a result of repeated bleeding episodes into joint spaces. Although administration of factor concentrates to prevent bleeding has been demonstrated to prevent haemophilic joint disease when applied assiduously, repeated bleeding episodes induce synovitis that is irreversible and may progress despite subsequent prophylaxis. Surgical and nuclear medicine interventions are available to reduce the pain of haemophilic arthropathy and to reduce further bleeding episodes. Patients with high titre inhibitors are at great risk for the development of joint disease and present the greatest therapeutic challenges when joint surgery is needed.

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Section: Radionucleotide Synovectomymentioning

confidence: 99%

Modern management of haemophilic arthropathy

2007

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“…Chromosomal abnormalities have been found in peripheral lymphocytes after radiosynovectomy. [6][7][8][9] The clinical significance of these changes remains unknown. To our knowledge, no studies of the incidence of cancer in patients who have received intra-articular yttrium injections have been reported.…”

mentioning

confidence: 99%

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Vuorela

Sokka²,

Pukkala³

et al. 2003

Annals of the Rheumatic Diseases

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“…Dvoreckij et al, 1971;Brewen et al, 1972;Pjatkin, 1976 , Ž in patients undergoing radiotherapy Tamura et al, 1970;Pyatkin et al, 1972b;Schmid et al, 1974a;Silberstein et al, 1974;Chee and Ilbery, 1975;Watson andGillies, . Ž 1975 or therapy with radionuclides Arbor, 1964;Cantolino et al, 1966;De la Chapelle et al, 1972;Stevenson et al, 1973;Blackwell et al, 1974;Boyd et al, 1974; . Lloyd et al, 1976 .…”

Section: ( ) Deõelopment and Standardization Of The Dicentric Dic Assaymentioning

confidence: 99%

How radiation-specific is the dicentric assay?

Hoffmann

Schmitz-Feuerhake

1999

J Expo Sci Environ Epidemiol

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Question: Quantitative cytogenetic analysis of structural chromosome aberrations in human peripheral blood lymphocytes is widely used as an assay to Ž . detect and quantify exposure to a variety of clastogens. Unstable chromosome rearrangements, dicentric chromosomes dic and centric ring chromosomes Ž . Ž . centric r , are routinely used as biomarkers to assess human exposure to ionizing radiation "biological dosimetry" . In the moderate-to high-dose range many authors consider the dic assay sufficiently radiation-specific for both practical and legal purposes. However, specificity has never been evaluated in quantitative terms. The high sensitivity of the assay would in principle allow for applications in the range of low-dose exposure which has been a major concern in epidemiologic studies. Validity of the assay then critically depends on specificity. Methods: A mathematical model is proposed which includes as parameters the decline of dicentric aberrations in ÕiÕo, the linear dose coefficient for the induction of dic and the average total radiation exposure of the population. To assess radiation-specificity of the dic assay the equilibrium dicentric rate due to radiation is compared to measurements of the background rate of dic in unexposed controls. Results: Environmental and medical radiation combined account for at least about 80% of the average background level of dicentrics. Conclusion: It is concluded that the dicentric assay is highly specific for ionizing radiation and can therefore be used to assess prior exposure in the dose range of interest in environmental epidemiology.

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Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose.

Cited by 69 publications

References 8 publications

Modern management of haemophilic arthropathy

Modern management of haemophilic arthropathy

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

How radiation-specific is the dicentric assay?

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