Chromosome analysis and comparison of the benign cystic and malignant squamous component of an ovarian teratoma

Noumoff, Joel S.; LiVolsi, Virginia A.; Deger, Randolph B.; Montone, Kathleen T.; Faruqi, Shamim A.

doi:10.1016/s0165-4608(00)00361-7

Cited by 14 publications

(7 citation statements)

References 7 publications

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“…Other cytogenetic analysis of mature ovarian teratomas showed a very low incidence of numerical and/or structural aberrations (5 -7%) with no consistency or recurrency (4,23,24). Furthermore, some reports described chromosomal anomalies in mature ovarian teratomas that undergo malignant transformation (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…However, some of them were also described in immature teratomas and in benign mature teratomas that undergo malignant transformation. Noumoff et al observed a del(X)(q11) in the malignant squamous component of an ovarian teratoma (24). Loss of heterozygosity on Xq is a common event in ovarian tumors and contributes to the progression of the tumor to an undifferentiated stage or aggressive behavior (25,26).…”

Section: Discussionmentioning

confidence: 99%

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Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies

Ciccarelli

Valdes-Socin

Parma

et al. 2004

European Journal of Endocrinology

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Objective: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We describe a case of struma ovarii that combined two different sources of hyperthyroidism in the same patient and report genetic studies in order to contribute a better understanding of the autonomy and tumorigenesis of the struma ovarii. Case report: A 73-year-old nulliparous woman presented a thyroid toxic adenoma that was successfully treated with 10 mCi radioiodine. Unexpectedly, a new onset of hyperthyroidism prompted us to look for a second etiology. A whole-body scan with 123 I detected a pelvic hyperfixation suggesting struma ovarii, and a thyroid differentiated left ovarian teratoma 3 cm in size was surgically removed. We screened for mutations of thyroid-stimulating hormone receptor and Gs-a protein genes, as these mutations are common in thyroid adenomas. We did not identify any mutations. Androgen receptor study demonstrated a monoclonal status. Comparative genomic hybridization did not reveal any chromosomal abnormality. However, loss of heterozygosity analysis showed several structural abnormalities, compared with the majority of benign ovarian teratomas, which show a normal karyotype. Conclusions: This is the first well-documented report of thyrotoxic struma ovarii revealed after treatment of a single thyroid toxic adenoma. We have shown in this case that struma ovarii originates from a single germ cell, and, albeit benign, this tumor presents several chromosomal abnormalities. Struma ovarii-induced hyperthyroidism is likely to be mediated by mechanisms different from those of the classical thyroid toxic adenoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies

Ciccarelli

Valdes-Socin

Parma

et al. 2004

European Journal of Endocrinology

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“…Regarding the origin of TMT it is known that isochromosome 12p, a typical marker for GCT occurs in somatic malignancies within malignant GCT. On the other hand, chromosomal rearrangements characteristic for the somatic malignancy have also been detected in single cases [23]. Moreover, numerical and structural chromosomal changes have been previously described in a TMT of the ovary and the corresponding underlying ovarian tissue.…”

Section: Cytogeneticsmentioning

confidence: 95%

Teratoma with Malignant Transformation: Experiences of the Cooperative GPOH Protocols MAKEI 83/86/89/96

Calaminus

Schneider

et al. 2006

Klin Padiatr

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Malignant transformation of pure teratomas constitutes a very rare entity in children and adolescents that is most commonly observed in postpubertal girls with ovarian teratoma. Compared to adult patients, similar malignant entities can be observed in association with teratoma. However, in our series, no sarcoma was diagnosed. In localised tumors, complete resection appears to be adequate, whereas chemotherapy should be considered in patients with R1- or R2-resection. Cisplatinum-based chemotherapy was effective as two of four relapsed patients survived tumor free. However, the ideal regimen has not yet been established and the known sensitivity of the histologic components to cytostatic drugs has to be considered in the choice of treatment. Further molecular biologic studies are necessary to understand the origin of these tumors.

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“…39,40 The homozygous nature of the malignant elements in these cases, which is similar to the benign elements, supports derivation of the former from the latter, 17 as do similar cytogenetic changes in the two components. 45 Additionally, immaturity in ovarian teratomas can be seen in a similar light as representing clones of malignant neuroepithelium that develop within a pre-existing teratoma.…”

Section: Dermoid and Epidermoid Cysts Of The Testismentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

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Chromosome analysis and comparison of the benign cystic and malignant squamous component of an ovarian teratoma

Cited by 14 publications

References 7 publications

Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies

Thyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies

Teratoma with Malignant Transformation: Experiences of the Cooperative GPOH Protocols MAKEI 83/86/89/96

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

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