Chromosomal Satellite Association in Women Using Oral Contraceptives and their Progeny

Bishun, N. P.; Mills, J.; Lloyd, Natasha; Williams, D. C.; Gristwood, E.

doi:10.1508/cytologia.37.639

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…(Hsu et al 1965). Some studies in humans show that SA is involved in the etiology of some numerical and structural chromosomal alterations implicated in reproductive failure (Bishun et al 1972, Houghton and Houghton 1978, Hassold and Jacob 1984, Sudhir et al 2016, Karaca et al 2019). However, the occurrence of SA in plants is little known and the specialized literature only records one investigation with Nothoscordum fragrans (Amaryllidaceae) where the high frequency of SA in NOR chromosomes was attributed to the nucleolar fusion recorded (Sato et al 1981).…”

Section: Discussionmentioning

confidence: 99%

Cytogenetics Analysis in Somatic Cells of <i>Dermatophyllum secundiflorum</i> (Mescal Bean) Reveals Satellite Association on Subtelocentric Chromosomes

Tapia-Pastrana

Tapia-Aguirre²

2021

CYTOLOGIA

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A cytogenetic analysis of chromosomes in mitotic metaphase of Dermatophyllum secundiflorum, a recently synonymized species, collected in the municipality of Cardonal (Hidalgo State, Mexico) was performed. The objective was not only to obtain the karyotype, but also cytogenetic markers such as secondary constrictions and satellites. A conventional method of air drying and Giemsa staining was used in cells from root meristems which confirmed a 2n=18. The formula for the haploid karyotype was 6m+2sm+1st sat . The secondary constrictions and microsatellites were clearly located on the short arm of the st chromosomes, which differs from a previous study that placed them on metacentric chromosomes. Occasionally, metaphase plates exhibited satellite associations involving the secondary constrictions and satellites of the st chromosomes, the role of which is discussed in light of the limited information available.

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Section: Discussionmentioning

confidence: 99%

Cytogenetics Analysis in Somatic Cells of <i>Dermatophyllum secundiflorum</i> (Mescal Bean) Reveals Satellite Association on Subtelocentric Chromosomes

Tapia-Pastrana

Tapia-Aguirre²

2021

CYTOLOGIA

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“…Studies of cultured lymphocytes de rived from contraceptive users have demon strated both positive and negative effects in the frequency of chromosome aberrations and aneuploidy [McQuarrie et al, 1970;Bishun et al. 1972;Shapiro et al.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Oral Contraceptives on Sister Chromatid Exchange, Blast Transformation, Mitotic Index and Micronuclei Formation

1983

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Lymphocytes from 5 individuals were cultured to study the effect of mestranol and norethindrone on sister chromatid exchange (SCE), blast transformation, mitotic index and micronuclei formation. Four combinations of the drugs were compared to water and ethanol controls. Some steroid combinations increased the SCE frequency compared to ethanol controls. There was no uniform effect on blast transformation or mitotic index. In 3 individuals, micronuclei formation was reduced in treated cultures. In conclusion, contraceptive steroids may be mutagenic in some individuals.

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The chromosomal effects of the oral contraceptive

Bishun

1982

Journal of Surgical Oncology

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A general review of reports on the chromosomal effects of oral contraceptive has been undertaken, and it is quite apparent that there is a scarcity of literature on these very important investigations. Also, those that have been undertaken, cannot be properly assessed on account of, one supposes, subjects' background and lack of numbers, differences in techniques and, above all, the small number of metaphases analyzed. Apart from the report by Mills and colleagues [16], none of the reports mentioned exogenous agents to which the subjects might have been exposed, especially in cases where there has been an increased frequency of chromosomal aberrations. All these considerations must be taken into account for, as yet, the reports are too conflicting to 'indict' the oral contraceptive as having chromosome-breaking properties.

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Chromosomal Satellite Association in Women Using Oral Contraceptives and their Progeny

Cited by 10 publications

References 4 publications

Cytogenetics Analysis in Somatic Cells of <i>Dermatophyllum secundiflorum</i> (Mescal Bean) Reveals Satellite Association on Subtelocentric Chromosomes

Cytogenetics Analysis in Somatic Cells of <i>Dermatophyllum secundiflorum</i> (Mescal Bean) Reveals Satellite Association on Subtelocentric Chromosomes

The Effect of Oral Contraceptives on Sister Chromatid Exchange, Blast Transformation, Mitotic Index and Micronuclei Formation

The chromosomal effects of the oral contraceptive

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