Chromosomal assignment of the two candidate genes (EGFR, CLCA1) for equine recurrent airway obstruction (RAO) by FISH and RH mapping

Klukowska‐Rötzler, Jolanta; Bugno, M.; Sander, Petra; Słota, E.; Dolf, G.; Chowdhary, Bhanu P.; Leeb, Tosso; Gerber, Vinzenz

doi:10.1111/j.2006.0018-0661.01947.x

Cited by 6 publications

(5 citation statements)

References 13 publications

(14 reference statements)

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“…Concurrently, a medium-density map of the horse genome was also reported by adding 165 gene-specific markers to the existing maps (Perrocheau et al 2006). Additionally, several research groups worldwide have used the RH panel to independently map a number of gene-specific and microsatellite markers during the period 2004Y2007 (e.g., Brenig et al 2004, Mickelson et al 2004, Takahashi et al 2004, Wagner et al 2004a,b,c, Beck et al 2005, Boneker et al 2005, Bricker et al 2005, Leeb et al 2005, Momozawa et al 2005, 2007, Muller et al 2005a,b,c, Wittwer et al 2005, Dranchak et al 2006a, Klukowska-Rotzler et al 2006a.…”

Section: Radiation Hybrid (Rh) Mapmentioning

confidence: 94%

“…This highresolution map is a valuable tool for the identification of genes and/or markers associated with economically important traits such as disease resistance/ susceptibility, growth, reproduction, and performance. The RH panel has been used to map candidate genes for equine conditions such as recurrent airway obstruction (Klukowska-Rotzler et al 2006a), glycogen storage disease IV (Ward et al 2003), and even for traits such as temperament and anxiety (Momozawa et al 2006(Momozawa et al , 2007. Bearing in mind that six years ago only õ350 markers were mapped in the horse, the high-resolution maps presently available for all chromosomes represent a major improvement in understanding the organization of the equine genome.…”

Section: Radiation Hybrid (Rh) Mapmentioning

confidence: 99%

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The Horse Genome Derby: racing from map to whole genome sequence

Chowdhary

Raudsepp

2008

Chromosome Res

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The map of the horse genome has undergone unprecedented expansion during the past six years. Beginning from a modest collection of approximately 300 mapped markers scattered on the 31 pairs of autosomes and the X chromosome in 2001, today the horse genome is among the best-mapped in domestic animals. Presently, high-resolution linearly ordered gene maps are available for all autosomes as well as the X and the Y chromosome. The approximately 4350 mapped markers distributed over the approximately 2.68 Gbp long equine genome provide on average 1 marker every 620 kb. Among the most remarkable developments in equine genome analysis is the availability of the assembled sequence (EquCab2) of the female horse genome and the generation approximately 1.5 million single nucleotide polymorphisms (SNPs) from diverse breeds. This has triggered the creation of new tools and resources like the 60K SNP-chip and whole genome expression microarrays that hold promise to study the equine genome and transcriptome in ways not previously envisaged. As a result of these developments it is anticipated that, during coming years, the genetics underlying important monogenic traits will be analyzed with improved accuracy and speed. Of larger interest will be the prospects of dissecting the genetic component of various complex/multigenic traits that are of vital significance for equine health and welfare. The number of investigations recently initiated to study a multitude of such traits hold promise for improved diagnostics, prevention and therapeutic approaches for horses.

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Section: Radiation Hybrid (Rh) Mapmentioning

confidence: 94%

Section: Radiation Hybrid (Rh) Mapmentioning

confidence: 99%

The Horse Genome Derby: racing from map to whole genome sequence

Chowdhary

Raudsepp

2008

Chromosome Res

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“…The map integrated genetic linkage data from 907 markers shared with the AHT and IHRFP maps. By comparing 1902 equine loci with sequence information from 8 other species, it was possible to identify candidate genes for equine conditions such as recurrent airway obstruction [6] and glycogen storage disease IV [7]. Comparative mapping in addition to cytogenetic and BAC contiguous maps have all contributed to acquiring adequate coverage of the horse genome.…”

Section: The Development Of An Equine Genetic Toolboxmentioning

confidence: 99%

Harnessing the genetic toolbox for the benefit of the racing Thoroughbred

Webbon

2011

Equine Veterinary Journal

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Summary The understanding and application of genetics have grown extremely quickly since it has become possible to sequence the whole genome of an organism. The human genome sequence was completed in 2001 and that of the horse in 2007. The significance of this is that it makes it more feasible to explain how both genetically simple and complex traits are transmitted from one generation to the next and, therefore, to make informed breeding decisions, modify how horses are managed and trained to minimise the risk of disease and injury, and improve methods of prevention, diagnosis and treatment of many conditions. The science of genetics/genomics will continue to grow internationally, limited only by the funds available. The application of the science to man, horses and other species raises very complex moral and commercial issues. Thoroughbred breeders are perceived by some as resistant to change, but their apparent intransigence is often based on a genuine concern for the integrity of the breed. By taking control of the application of the advances in genetics, the Thoroughbred industry potentially has the opportunity to improve both the health and performance of Thoroughbreds. If, however, the science is applied in an uncoordinated manner, driven by commercial interests with no underlying concern for the horses themselves, there is a very real risk that breeders, the Thoroughbred breed and individual horses will all suffer as a consequence.

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“…于 31 条常染色体和X染色体的 1 144 个FISH标记 [11] 。 Looft等 [12] 利用FISH图谱将 6 个基因组BAC克隆定位于 ECA 27q17 。最近所研究的马 ATP2A2 [13] 、 EIF2AK2 [14] 、EGFR、CLCA1 [15] 、HTR [16] 、RSPO [17] 等基因都是应用了FISH图谱进行基因定位的。FISH在染色体重排等复杂的细胞遗传学分析中也是一种有效的补充工具 [18] 。…”

Section: 遗传连锁图谱unclassified

Progress on horse genome project

Yang

Ma²,

Li³

et al. 2010

Hereditas (Beijing)

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There is unique genetic information belonging to various kinds of living beings. Understanding of the formation process of organisms and a variety of vital movement is associated with the achievements of genome study. As horse has a notable health condition and great record of the genealogy in the world, thus it becomes a valuable model animal for studying life science. Despite of a late start, the map of the horse genome has undergone unprecedented expansion during the last few years. The current progresses of the horse genome, including genetic map, physical map, comparative genomic map, and functional genomics, were reviewed in this paper. The maps are currently used worldwide to discover genes associated with various traits of significance in horse including general health, disease resistance, reproduction, fertility, athletic performance, phenotypic characteristics like coat color, etc. The results are believed to provide new ideas and approaches for prevention, diagnostics, and therapeutic for horses, and also better foundation of breed selection and equine genetic breeding.

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Chromosomal assignment of the two candidate genes (EGFR, CLCA1) for equine recurrent airway obstruction (RAO) by FISH and RH mapping

Cited by 6 publications

References 13 publications

The Horse Genome Derby: racing from map to whole genome sequence

The Horse Genome Derby: racing from map to whole genome sequence

Harnessing the genetic toolbox for the benefit of the racing Thoroughbred

Progress on horse genome project

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