Progress on horse genome project

Yang, Hong; Ma, Yuehui; Li, Bei; Dugarjaviin, Manglai

doi:10.3724/sp.j.1005.2010.00211

Cited by 4 publications

(4 citation statements)

References 56 publications

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“…Horses however did not fade from human life. In many countries, horses have become domestic animals of social and economic value [28]. Different breeds are the result of the past long-term human and natural selection.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Detection of Copy Number Variations among Diverse Horse Breeds by Array CGH

Wang

Hou

et al. 2014

PLoS ONE

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Recent studies have found that copy number variations (CNVs) are widespread in human and animal genomes. CNVs are a significant source of genetic variation, and have been shown to be associated with phenotypic diversity. However, the effect of CNVs on genetic variation in horses is not well understood. In the present study, CNVs in 6 different breeds of mare horses, Mongolia horse, Abaga horse, Hequ horse and Kazakh horse (all plateau breeds) and Debao pony and Thoroughbred, were determined using aCGH. In total, seven hundred CNVs were identified ranging in size from 6.1 Kb to 0.57 Mb across all autosomes, with an average size of 43.08 Kb and a median size of 15.11 Kb. By merging overlapping CNVs, we found a total of three hundred and fifty-three CNV regions (CNVRs). The length of the CNVRs ranged from 6.1 Kb to 1.45 Mb with average and median sizes of 38.49 Kb and 13.1 Kb. Collectively, 13.59 Mb of copy number variation was identified among the horses investigated and accounted for approximately 0.61% of the horse genome sequence. Five hundred and eighteen annotated genes were affected by CNVs, which corresponded to about 2.26% of all horse genes. Through the gene ontology (GO), genetic pathway analysis and comparison of CNV genes among different breeds, we found evidence that CNVs involving 7 genes may be related to the adaptation to severe environment of these plateau horses. This study is the first report of copy number variations in Chinese horses, which indicates that CNVs are ubiquitous in the horse genome and influence many biological processes of the horse. These results will be helpful not only in mapping the horse whole-genome CNVs, but also to further research for the adaption to the high altitude severe environment for plateau horses.

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Section: Introductionmentioning

confidence: 99%

Genome-Wide Detection of Copy Number Variations among Diverse Horse Breeds by Array CGH

Wang

Hou

et al. 2014

PLoS ONE

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“…It is economically important throughout the world and has been used for transportation and entertainment. Moreover, horse is a medically valuable animal model because the species shares over 90 hereditary conditions with human disorders [27]–[28] as well as many medical conditions such as allergies and osteoarthritis [29]–[30]. Furthermore, horse can be a valuable model organism for studying biomechanics and exercise physiology [31].…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of MicroRNAs in Normal Equine Tissues by Next Generation Sequencing

et al. 2014

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The role of microRNAs (miRNAs) as a post-transcriptional gene regulator has been elucidated in a broad range of organisms including domestic animals. Characterization of miRNAs in normal tissues is an important step to investigate the functions of miRNAs in various physiological and pathological conditions. Using Illumina Next Generation Sequencing (NGS) technology, we identified a total of 292 known and 329 novel miRNAs in normal horse tissues including skeletal muscle, colon and liver. Distinct sets of miRNAs were differentially expressed in a tissue-specific manner. The miRNA genes were distributed across all the chromosomes except chromosomes 29 and 31 in the horse reference genome. In some chromosomes, multiple miRNAs were clustered and considered to be polycistronic transcript. A base composition analysis showed that equine miRNAs had a higher frequency of A+U than G+C. Furthermore, U tended to be more frequent at the 5′ end of miRNA sequences. This is the first experimental study that identifies and characterizes the global miRNA expression profile in normal horse tissues. The present study enriches the horse miRNA database and provides useful information for further research dissecting biological functions of miRNAs in horse.

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“…The running speed of the server affects the resource scheduling speed for vast calculation. The operation mode is similar to the GPS navigation system [3] .…”

Section: Development Of Integrated Googlementioning

confidence: 99%

Design and Realization of the Intelligent Scheduling and Management System of Transmission Lines

Wang

Xu²

2011

AMR

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Transmission line intelligent distribution and management system is the latest systematic product for optical network intelligent distribution, with the function of detecting, warning and information processing, whose purpose is to realize the delicacy management of transmission line resources and solve the problems appearing in the process of using resource management system., such as input complexity, function singleness and so on. The thesis introduces different functions of each module in this system, puts forward the solutions to this systematic function and provides some realization codes.

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Progress on horse genome project

Cited by 4 publications

References 56 publications

Genome-Wide Detection of Copy Number Variations among Diverse Horse Breeds by Array CGH

Genome-Wide Detection of Copy Number Variations among Diverse Horse Breeds by Array CGH

Identification and Characterization of MicroRNAs in Normal Equine Tissues by Next Generation Sequencing

Design and Realization of the Intelligent Scheduling and Management System of Transmission Lines

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