Chromosomal Anomalies in Patients with Azoospermia and Oligoasthenoteratozoospermia

Vijayalakshmi, J.; Venkatchalam, P.; Paul, Solomon F.D.; Rani, G Usha; Kumarasamy, P.; Kannan, Jayam

doi:10.1080/09723757.2011.11886133

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…These are all due to non-disjunction which may involve in meiosis. An increase in the length of heterochromatic regions namely 1qh+, 9qh+, 15p+, 21p+, 22p+ and Yqh+ were noted in azoospermia and oligoasthenoteratozoospermia groups of infertile men and the pericentric inversion inv(9qh) was noted in one case of azoospermia 19 .…”

Section: Discussionmentioning

confidence: 94%

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Chromosomes Abnormalities Among Recurrent Spontaneous Abortions Cases

Janani¹,

Murugan²,

Santhiya³

2016

Biomed. Pharmacol. J.

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Spontaneous abortion in the first trimester of pregnancy is problem among Indian women accounting for 15 to 20 percent pregnancy loss. Couples with abortion histories are probably at greater risk for cytogenetic abnormality than the couples with normal children. The abnormality associated with recurrent pregnancy loss includes translocation, inversions, recurrent aneuploidy, marker or supernumerary chromosomes, heterochromatic polymorphic etc. Hence, the present study is focused to assess the prevalence of chromosomal abnormalities among couples with repeated abortion cases. It was extrapolated that repeated pregnancy loss has was very common with abnormality in the 22p(stk+) in male.

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Section: Discussionmentioning

confidence: 94%

“…Pooling the data from the different series of infertile males, 0.5% reciprocal translocations were observed as compared to 0.1% in the newborn children. The correlation between reciprocal translocations with involvement of chromosomes 3, 4, 5,6,7,9,11,13,14,15,16,17,19,20,21,22 and the impairment of sperm production is well known 11 .…”

Section: Introductionmentioning

confidence: 99%

Chromosomes Abnormalities Among Recurrent Spontaneous Abortions Cases

Janani¹,

Murugan²,

Santhiya³

2016

Biomed. Pharmacol. J.

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“…Later fix in equal parts of 95% ethanol and ether for 5-15 minutes. Oligozoospermia is defined as low concentration of sperm [22] and Oligoasthenozoospermia is defined as reduced sperm motility and count [23] and Oligoasthenoteratozoospermia is defined as decrease in the sperm count, poor movement and abnormal shape of sperms [24].…”

Section: Assessment Of Sperm Concentrationmentioning

confidence: 99%

Semen analysis in smokers and non-smokers

Singh

Thotakura

2018

Trop J Pathol Microbiol

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Background: Semen analysis still remains as a simple, cost effective screening test for evaluation of male in fertility clinic, which provides information on quantitative and qualitative aspects of testicular function. Except in cases of azoospermia, semen analysis does not separate patients in to sterile and fertile group. Objective: The present study was undertaken to perform the quantitative and qualitative Analysis of Semen and to compare the sperm parameters in smokers and non-smokers. Materials and methods: A total of 150 cases referred to Pathology department for semen analysis in Katuri Medical College & Hospital, from September 2016 to August 2018 were included in the study. The following criteria was used in the selection of the participants. Results: The overall quality of sperm was significantly decreased in smokers when compared with non-smokers. Conclusion: Semen parameters like volume, motility, count, morphologically normal spermatozoa were reduced in cigarette smokers when compared to Non-smokers, but only sperm count was found to have a high significant decrease in Smokers (P: <0.01 ) when compared to Non-smokers. In concordance with other researchers, results of present study support that cigarette smoking have a relatively significant effect on semen. patients in to sterile and fertile group [2]. In recent years, infertility and sub fertility in men has increased which may be associated with their advancing age, habits like tobacco use, alcoholism, working environment, varicocele and other factors. Semen parameters might be sensitive markers for these influencing factors [3,4], hence our study focuses on effects of factors like cigarette smoking on semen parameters. The present study was undertaken to perform the quantitative and qualitative Analysis of Semen and to Compare the sperm parameters in smokers and non-smokers.

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“…Аналіз частот кількісних і структурних перебудов у підгрупах пацієнтів залежно від ступеня тяжкості порушення сперматогенезу виявив достовірне (Р < 0,001) підвищення частоти кількісних аномалій у пацієнтів з азооспермією. Наші результати узгоджуються з попередніми даними про те, що кількісні аномалії гоносом частіше виявляють у пацієнтів з азооспермією, у той час як структурні перебудови реєструють, в основному, у пацієнтів з оліго-та астенозооспермією (Elghezal et al, 2006;Rao et al, 2006;Vijayalakshmi et al, 2011).…”

Section: результати та їх обговоренняunclassified

Хромосомні Аномалії У Чоловіків Із Різним Ступенем Порушення Сперматогенезу

Pylyp¹,

Spinenko²,

Zukin³

et al. 2013

VDNUBM

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Chromosomal abnormalities are among the most common genetic causes of spermatogenic disruptions. Carriers of chromosomal abnormalities are at increased risk of infertility, miscarriage or birth of a child with unbalanced karyotype due to the production of unbalanced gametes. The natural selection against chromosomally abnormal sperm usually prevents fertilization with sperm barring in cases of serious chromosomal abnormalities. However, assisted reproductive technologies in general and intracytoplasmic sperm injection in particular, enable the transmission of chromosomal abnormalities to the progeny. Therefore, cytogenetic studies are important in patients with male factor infertility before assisted reproduction treatment. The purpose of the current study was to investigate the types and frequencies of chromosomal abnormalities in 724 patients with infertility and to estimate the risk of chromosomal abnormalities detection in subgroups of patients depending on the severity of spermatogenic disruption, aiming at identifying groups of patients in need of cytogenetic studies. Karyotype analysis was performed in 724 blood samples of men attending infertility clinic. Chromosomal preparation was performed by standard techniques. At least 20 GTG-banded metaphase plates with the resolution from 450 to 750 bands per haploid set were analysed in each case. When chromosomal mosaicism was suspected, this number was increased to 50. Abnormal karyotypes were observed in 48 (6.6%) patients, including 67% of autosomal abnormalities and 33% of gonosomal abnormalities. Autosomal abnormalities were represented by structural rearrangements. Reciprocal translocations were the most common type of structural chromosomal abnormalities in the studied group, detected with the frequency of 2.6% (n = 19), followed by Robertsonian translocation, observed with the frequency of 1.2% (n = 9). The frequency of inversions was 0.6% (n = 4). Gonosomal abnormalities included 14 cases of sex chromosome aneuploidy and 2 cases of terminal deletion of Y chromosome. Klinefelter syndrome was detected in 67% of patients with azoospermia. A significant increase in the frequency of numerical chromosomal abnormalities was observed in a group of patients with azoospermia (P < 0.001). No differences were detected in the frequency of structural abnormalities in subgroups of patients. An increase in the frequency of chromosomal abnormalities with the decrease of sperm count was observed. Chromosomal abnormalities were detected with frequency 1.1% in a group of patients with normospermia, 1.9% in a group of patients with asthenozoospermia, 4.3% in patients with asthenoteratozoospermia, 6.5% in patients with oligoasthenozoospermia, 11.6% in patients with oligoasthenoteratozoospermia and 35% in a group of patients with azoospermia. Significant increase of the prevalence of chromosomal abnormalities was detected in subgroups of patients with azoospermia (P < 0.001) and oligozoospermia (P = 0.001) as compared to patients with normozoospermia. These results are considered to be criteria for selection of patients in need of cytogenetic studies before in vitro fertilization cycles because of the highest risk of chromosomal abnormalities detection.

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Chromosomal Anomalies in Patients with Azoospermia and Oligoasthenoteratozoospermia

Cited by 9 publications

References 3 publications

Chromosomes Abnormalities Among Recurrent Spontaneous Abortions Cases

Chromosomes Abnormalities Among Recurrent Spontaneous Abortions Cases

Semen analysis in smokers and non-smokers

Хромосомні Аномалії У Чоловіків Із Різним Ступенем Порушення Сперматогенезу

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