Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure

Saxena, Shailaja Gada; Desai, Kundanbala; Shewale, L.; Ranjan, Prabhat; Saranath, Dhananjaya

doi:10.1016/j.rbmo.2012.04.004

Cited by 36 publications

(41 citation statements)

References 33 publications

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“…It was noted as 0.7% [19] , 0.8% [20] and 0.6% [18] in other studies which is less as compared to our study. In the present study this type of abnormality was 1.16% in both male and female, whereas in other study it was found to be 0.5% in males [21] and 0.6% in females [15] .…”

Section: Discussioncontrasting

confidence: 92%

Robertsonian Translocation Between Chromosome Number 13 And 14 Associated With Recurrent Pregnancy Loss

Saba¹,

Rk²,

Rani³

et al. 2016

IOSR

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Section: Discussioncontrasting

confidence: 92%

Robertsonian Translocation Between Chromosome Number 13 And 14 Associated With Recurrent Pregnancy Loss

Saba¹,

Rk²,

Rani³

et al. 2016

IOSR

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“…Recurrent miscarriage, defined as three or more consecutive pregnancy losses before 20-22 weeks of gestation, is a common clinical problem (Gada Saxena et al, 2012). Recurrent spontaneous abortions (RSAs) occur in approximately 15-20% of all clinically recognizable pregnancies (Dutta et al, 2011;Gada Saxena et al, 2012;Turki et al, 2014;Ghazaey et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Recurrent spontaneous abortions (RSAs) occur in approximately 15-20% of all clinically recognizable pregnancies (Dutta et al, 2011;Gada Saxena et al, 2012;Turki et al, 2014;Ghazaey et al, 2015). RSA is considered a multifactorial problem, with different causes involved in its etiology, including genetic, environmental, endocrine, and infectious diseases (Gonçalves et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The frequency of chromosomal abnormalities among couples with RSAs varies from 2 to 8% (Sheth et al, 2013;Ghazaey et al, 2015). Balanced chromosomal rearrangements have been found at an increased frequency in couples with RSAs, compared with the general population (Makino et al, 1990;Gada Saxena et al, 2012;Sheth et al, 2013;Nonaka et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structural chromosomal abnormalities in couples in cases of recurrent spontaneous abortions in Jilin Province, China

Ht¹,

Zhang²,

Zhan³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Recurrent spontaneous abortions (RSAs) occur in approximately 15 to 20% of all clinically recognizable pregnancies. Structural chromosome abnormalities result in increased risk of pregnancy loss. Parental chromosomal abnormalities are an important genetic cause of RSAs. Some cytogenetic investigations have been performed in various countries and regions to determine the pattern of chromosomal abnormalities in parents with RSAs. The aim of this study was to report the prevalence and type of structural chromosomal abnormalities in couples in cases of RSAs in Jilin Province, China. The prevalence of structural chromosomal abnormalities in these couples was 2.98%. The number of female carriers with balanced chromosomal aberrations significantly exceeded that of such male carriers, and the ratio of female/male carriers was approximately 2:1. The number of abortions in the case of female carriers was more than that for male carriers before the structural chromosome abnormality was diagnosed. This indicates that genetic counseling for couples with structural chromosomal abnormalities should consider the gender of the carriers.

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“…Following this additional 21 patients have undergone PGS for aneuploidy screening (data not included), with 10 pregnancies, including 1 twin pregnancy, showing favorable outcome for PGS. It is thus imperative to integrate basic genetic services into the existing primary health care and medical services including karyotyping in couples with reproductive failure,[26] PGS using FISH in the absence of availability of microarray based technology for PGS and community control of common genetic aberrations as priority needs for biomedical intervention.…”

Section: Discussionmentioning

confidence: 99%

Pre-implantation genetic screening using fluorescence in situ hybridization in couples of Indian ethnicity: Is there a scope?

Saxena¹,

Desai²,

Shewale³

et al. 2014

J Hum Reprod Sci

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CONTEXT:There is a high incidence of numerical chromosomal aberration in couples with repeated in vitro fertilization (IVF) failure, advanced maternal age, repeated unexplained abortions, severe male factor infertility and unexplained infertility. Pre-implantation genetic screening (PGS), a variant of pre-implantation genetic diagnosis, screens numerical chromosomal aberrations in couples with normal karyotype, experiencing poor reproductive outcome. The present study includes the results of the initial pilot study on 9 couples who underwent 10 PGS cycles.AIM:The aim of the present study was to evaluate the beneficial effects of PGS in couples with poor reproductive outcome.SETTINGS AND DESIGN:Data of initial 9 couples who underwent 10 PGS for various indications was evaluated.SUBJECTS AND METHODS:Blastomere biopsy was performed on cleavage stage embryos and subjected to two round fluorescence in situ hybridization (FISH) testing for chromosomes 13, 18, 21, X and Y as a two-step procedure.RESULTS:Six of the 9 couples (10 PGS cycles) conceived, including a twin pregnancy in a couple with male factor infertility, singleton pregnancies in a couple with secondary infertility, in three couples with adverse obstetric outcome in earlier pregnancies and in one couple with repeated IVF failure.CONCLUSION:In the absence of availability of array-comparative genomic hybridization in diagnostic clinical scenario for PGS and promising results with FISH based PGS as evident from the current pilot study, it is imperative to offer the best available services in the present scenario for better pregnancy outcome for patients.

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Chromosomal aberrations in 2000 couples of Indian ethnicity with reproductive failure

Cited by 36 publications

References 33 publications

Robertsonian Translocation Between Chromosome Number 13 And 14 Associated With Recurrent Pregnancy Loss

Robertsonian Translocation Between Chromosome Number 13 And 14 Associated With Recurrent Pregnancy Loss

Structural chromosomal abnormalities in couples in cases of recurrent spontaneous abortions in Jilin Province, China

Pre-implantation genetic screening using fluorescence in situ hybridization in couples of Indian ethnicity: Is there a scope?

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