Chromones and coumarins from Skimmia laureola

Waight, E. S.; Razdan, T. K.; Qadri, B.; Harkar, S.

doi:10.1016/s0031-9422(00)81759-8

Cited by 100 publications

(20 citation statements)

References 11 publications

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“…From the CH 2 Cl 2 extract: Fraction 15-18 gave scoparone (100% CH 2 Cl 2 , 25 mg) (Razdan et al, 1987), fraction 19-20 eluted using 100% CH 2 Cl 2 gave scopoletin (6, 100% CH 2 Cl 2 , 15 mg) (Imai et al, 1989), fraction 5-13 eluted using 1:1 hexane:methylene chloride gave oleanolic acid (7, 10% EtOAc/hexane, 70 mg) (Ahmad and Rahman, 1994) and lupeol (8, 10% EtOAc/hexane, 20 mg) . …”

Section: Phytochemistry Lettersmentioning

confidence: 99%

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Langat

Milijaona

Langat

et al. 2014

Phytochemistry Letters

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Section: Phytochemistry Lettersmentioning

confidence: 99%

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Langat

Milijaona

Langat

et al. 2014

Phytochemistry Letters

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“…SLJ0003) was deposited in the Department of Natural Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, China. Aviprin, isopimpinellin, bergapten, isooxypeucedanin, gosferol, imperatorin, phellopterin, isoimperatorin were extracted, separated and purified from the dried roots of Zijinsha in our laboratory and their structures were elucidated by comparison of their spectral data (UV, MS and NMR) with those of references [25][26][27][28][29][30]. The purity of these reference substances were determined to be more than 95% by TLC and normalization of the peak areas detected by LC with UV detecting wavelength at 300 nm.…”

Section: Reagents and Materialsmentioning

confidence: 99%

Simultaneous Qualitative Analysis of Coumarins in the Rhizome of Angelica polymorpha Maxim. by LC–DAD–ESI–MS

Liu

Yu²,

et al. 2011

Chromatographia

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A novel method has been developed for simultaneous qualitative analysis of coumarins in the rhizome of Angelica polymorpha Maxim. with the use of high-performance liquid chromatography (LC)-photodiode array detection (DAD)-electrospray ionization (ESI)-tandem mass spectrometry (MS). LC analysis was performed on an Agilent Eclipse XDB-C 18 analytical column with a gradient solvent system of water and methanol, ultraviolet (UV) absorption detection was at 300 nm and peak UV spectrum and (?) ESI-MS data were acquired by DAD and a quadrupole mass spectrometer, respectively. Eight peaks were identified as linear furocoumarins including aviprin, isopimpinellin, bergapten, isooxypeucedanin, gosferol, imperatorin, phellopterin and isoimperatorin by comparing their retention time, UV, and MS spectra with that of the authentic standards, and the analysis of UV spectra and ESI-MS data of the standards gave the characteristics of UV absorption and ESI-MS fragmentation. On the basis of the above characteristics, the possible structures of four other linear furocoumarins were deduced in LC. The other chemical structures were proposed as three angular furocoumarins, a simple coumarin, two chromones, and a cinnamic acid by comparing their UV and MS data with that of literature reports. Accordingly, the method we established can simply and accurately identify the key chemical constituents in the rhizome of A. polymorpha.

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“…The known isolates were readily identified by a comparison of physical and spectroscopic data (UV, IR, 1 H-NMR, [α] D , and MS) with corresponding authentic samples or literature values, and this included 13 coumarins, murraol ( 4 ) [12,13], peroxymurraol ( 5 ) [12,13], osthol ( 6 ) [12,17], osthenol ( 7 ) [18], auraptenol ( 8 ) [6,19], peroxyauraptenol ( 9 ) [12] [13], meranzin hydrate ( 10 ) [12,13], demethylauraptenol ( 11 ) [20], xanthotoxin ( 12 ) [17,21], xanthotoxol ( 13 ) [17], imperatorin ( 14 ) [17], bergapten ( 15 ) [17,21], and isopimpinellin ( 16 ) [17,21], and a chromone, cnidimol A ( 17 ) [22]. …”

Section: Resultsmentioning

confidence: 99%

New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri

Lee

Chen

Hwang

et al. 2014

IJMS

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The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4–17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–12, and 14–17 exhibited inhibition (IC50 ≤ 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9–11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.

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Chromones and coumarins from Skimmia laureola

Cited by 100 publications

References 11 publications

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Simultaneous Qualitative Analysis of Coumarins in the Rhizome of Angelica polymorpha Maxim. by LC–DAD–ESI–MS

New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri

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