Chromone-based Schiff base metal complexes as catalysts for catechol oxidation: Synthesis, kinetics and electrochemical studies

Beyazit, Neslihan; Çakmak, Didem; Demetgül, Cahıt

doi:10.1016/j.tet.2017.03.081

Cited by 34 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metal complexes, particularly those containing sp 2 hybrid nitrogens as part of the aromatic system of the ligands, find significant applications as drugs . Schiff bases containing nitrogen heterocyclic moieties act as efficient ligands and form chelating complexes with transition metal ions . Several derivatives of quinoxaline were reported to exhibit a wide range of pharmacological activities such as antimicrobial, anti‐inflammatory, antidiabetic, antitumour and antidepressant activities, in addition to their use in catalysis and organic synthesis .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

Sukanya

Reddy

2018

Applied Organom Chemis

View full text Add to dashboard Cite

A Schiff base ligand, 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one (BZHQO), has been synthesized by the condensation of 3‐hydrazinylquinoxalin‐2(1H)‐one and 1‐(1H‐benzoimidazol‐2‐yl) ethanone and characterized using spectral and single‐crystal X‐ray analyses. Mn (II), Co (II), Ni (II) and Cu (II) complexes of the BZHQO ligand have been synthesized and characterized. The interactions of the ligand and its metal complexes with calf thymus DNA have been investigated using absorption spectroscopy and the intrinsic binding constant has been evaluated. Agarose gel electrophoresis has been performed to study the abilities of the ligand and its metal complexes to cleave supercoiled pBR322 DNA into nicked circular form. In vitro anticancer activities of the Cu (II) and Ni (II) complexes have been investigated by MTT assay, using the cell lines HeLa, B16‐F10, SKOV3 and MCF7. The Cu (II) complex has been found to be active against HeLa, B16‐F10 and MCF7, while the Ni (II) complex has been found to be active against MCF‐7.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

Sukanya

Reddy

2018

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…Docking of the synthesized heterocyclic Schiff base derivative (1-8) was carried out with DNA duplex of the Compounds 1-5 showed heist binding activity with 1BNA followed by other compounds, as shown in Table 1. Docked compounds were analysed in terms of hydrogen bonding, energy, noncovalent, and hydrophobic interaction between compounds and DNA ( Figure 6) [48,49]. e docked results clearly explained that there is strong interaction between the compounds and 1BNA.…”

Section: Circular Dichroism Study Circular Dichroism (Cd)mentioning

confidence: 99%

Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases

Almarhoon

Al-onazi

Alothman

et al. 2019

Journal of Chemistry

View full text Add to dashboard Cite

A new series of p-dimethylaminobenzaldehyde derivatives were tested for therapeutic potential by exploring their properties through characterization. The derivatives were synthesized by 1 : 1 condensation reaction of p-dimethylaminobenzaldehyde and substituted amines. The synthesized compounds 1–8 were characterized by different characterization techniques including IR, mass, 1H NMR, and 13C NMR spectroscopy, elemental analysis, and mass spectrometry. Furthermore, binding of these Schiff bases to Ct-DNA was examined by absorption spectroscopy, fluorescence quenching, circular dichroic, viscosity measurement, molecular docking, and molecular dynamics simulation methods. Schiff bases were tested for antimicrobial activity against bacterial species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus by the disc diffusion method. The pharmacological treatment of Schiff bases showed that 1–8 have promising potential against tested bacterial strains. The molecular docking study of the target compounds was also carried out against B-DNA dodecamer d(CGCGAATTCGCG)2, and it has been found that 1–8 can bind to Ct-DNA via an intercalative mode. DPPH free radical and hydrogen peroxide scavenging assays were employed to assess the antioxidant potential of synthesized Schiff bases.

show abstract

“…Catecholase widespread in plant enzyme, to save plant from harm result by insects and pathogens by catalytic oxidation of catechol to o-quinones in the presence of oxygen air [14,15] catecholase activity mimicking by biomaterials structural, metal complexes considered in recent years the most important in a study of their catalytic activity in oxidation reactions [16] in spite of the powerful site of catecholase enzyme consists of a hydroxo-bridged dicopper(II) center, it is fully certified that many monometallic complexes of Mn(II) [17], Ni(II) [18], copper(II) [19] and Fe(II) [20] are show catecholase activity.…”

Section: Introductionmentioning

confidence: 99%

New Nickel Metal Complex towards Biomimetic Catecholase Enzyme Oxidation: Synthesis and Kinetics Studies

Al-Sayed¹

2018

BMB

View full text Add to dashboard Cite

Pyrano[2,3-c]pyrazole ligand and their transition metal complex with nickel (Ni II MPC) were synthesized and characterization by elemental analyses, magnetic susceptibility, FT IR, UV-Vis, and mass spectroscopy. Complex have been investigated as functional models for catechol oxidase activity by using a catechol as a model substrate. According to the kinetic measurement results, the rate of catechol oxidation follows first order kinetics. Nickel complex has been used in homogenous oxidation of catechol in presence of a green oxidant H 2 O 2. kinetic parameters were obtained V max = 2.

show abstract

Chromone-based Schiff base metal complexes as catalysts for catechol oxidation: Synthesis, kinetics and electrochemical studies

Cited by 34 publications

References 35 publications

Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases

New Nickel Metal Complex towards Biomimetic Catecholase Enzyme Oxidation: Synthesis and Kinetics Studies

Contact Info

Product

Resources

About