Chromogenic, Specific Detection of the Nerve‐Agent Mimic DCNP (a Tabun Mimic)

Abstract

Pybox schafft das Umfeld: Hoch enantioselektive Aminierungen allylischer und benzylischer C‐H‐Bindungen werden durch kationische Ruthenium(II)‐Pybox‐Komplexe katalysiert (siehe Struktur). Die ausgezeichnete Enantioselektivität dieser Reaktionen wurde auf eine neue Form der Stereokontrolle durch den Pybox‐Liganden zurückgeführt. Boc=tert‐Butoxycarbonyl, pybox=Pyridinbis(oxazolin).

A Molecular Probe for the Highly Selective Chromogenic Detection of DFP, a Mimic of Sarin and Soman Nerve Agents

“…For instance, even though the emergency response protocol is similar for all nerve gases, different toxicities and experimental evidence that some antidotes are ineffective for certain nerve agents indicate the importance of distinguishing certain agents within this family of lethal chemicals. [18] Following our interest in the development of chromofluorogenic probes for nerve agents, [15,17] we report herein a simple colorimetric system that is not only able to respond to nerveagent mimics, but is also able to distinguish DFP (a mimic of Sarin and Soman nerve gases) from other simulants and organophosphates. The signaling protocol involves chromogenic probe 1 (Scheme 1).…”

Functionalized Gold Nanoparticles as an Approach to the Direct Colorimetric Detection of DCNP Nerve Agent Simulant

“…The addition of 30 equiv. [6] On the basis of these results we expected that the phosphorylation of the pyridine moiety in nanoparticles AuNP2-AuNP7 or the formation of an ammonium salt in AuNP8 promoted by the presence of DCNP would change the overall electrostatic charge on the surfaces of the nanoparticles, triggering an aggregation process coupled with a bathochromic shift of the SPR absorption band and a change in the color of the solution. The UV spectrum of ligand 7 in acetonitrile (5 ϫ 10 -5 m) shows a band centred at 454 nm (log ε = 4.15 m -1 cm -1 ).…”

“…[3] However, these protocols usually have limitations, such as low selectivity, poor portability and a certain level of complexity. [6] In both cases, the reaction between the probe and the simulant generates a positive charge on the molecule. [4] Colorimetric detection is particularly appealing because it uses low-cost, widely available instruments and allows assays to be detected by the naked eye.…”

Anionic chromogenic chemosensors highly selective for cyanide based on the interaction of phenyl boronic acid and solvatochromic dyes

“…This anion is lethal in very small amounts due to its ability to bind strongly to the active site of cytochrome-oxidase, which leads to the inhibition of the mitochondrial electron transport chain and consequently to a decrease in the oxidative metabolism [21][22][23]. Many chemical warfare compounds, such as sarin, soman, and tabun [26][27][28] deliver F − and CN − through hydrolysis [29] and this has motivated the development of efficient optical chemosensors able to detect these neurotoxic agents [30][31][32][33].…”