Chromogenic and fluorogenic detection and discrimination of nerve agents Tabun and Vx

Abstract

Our approach uses squaraine (SQ) as the molecular-receptor as well as an indicator for the chromogenic and fluorogenic detection and discrimination of nerve agents Tabun and Vx. To mimic a real-life scenario, the protocols were implemented in spiked water and soil samples, on surfaces, and in the gas phase. The lower detection limit will be useful to protect human health and national security.

A Naphthalimide‐Based Fluorescent Turn‐On Sensor for the Selective Detection of Diethyl Chlorophosphate

“…Moreover, as can be seen from 31 P NMR spectrum(Figure S12, Supporting Information), 31 P signal of AEN‐DCP complex arose at 4.18 ppm and showed an observable shift to higher field comparing to the 31 P NMR spectrum without AEN. These NMR titration results jointly demonstrated that the nucleophilic substitution reaction may occur between the amino group of AEN and DCP to form phosphinate product . The formation of the 1:1 AEN‐DCP complex was also evidenced by ESI‐MS.…”

A Self-Degradable Hydrogel Sensor for a Nerve Agent Tabun Surrogate Through a Self-Propagating Cascade

“…The Kumar group has reported the analysis of cyanide due to its nucleophilic ability after being released from an analogous mimic. [29][30][31] In our study, the two reactions that use initiator 4 were anticipated to impart selectivity to the sensing event. To test this, we conducted experiments on three nerve agent surrogates (Figures S10-S12).…”

A Single Fluorescent Chemosensor for Simultaneous Discriminative Detection of Gaseous Phosgene and a Nerve Agent Mimic

“…The broad utility of chemosensors is a consequence of their high selectivity and sensitivity, facile operation, and capability for use in situ and real-time detection. − Not unexpectedly, a number of fluorescent chemosensors have been devised for the detection of phosgene and nerve agents. However, the majority of these chemosensors respond only to phosgene or nerve agents and not both. − So far, only one fluorescent chemosensor for discrimination between phosgene and the nerve gas mimic diethyl chlorophosphate (DCP) has been developed based on pyronin Y and o -phenyenediamine (OPD) . Compared with those chemosensors that can be used to sense only one analyte, single fluorescent chemosensors that generate different emission responses toward multiple targets are advantageous for two reasons: (1) they are more economical and (2) they avoid cross-talk that can occur when two or more fluorescent chemosensors are utilized simultaneously. , Nevertheless, pyronin Y can easily undergo a nucleophilic addition reaction with some nucleophilic species, which affects the selectivity of this sensor.…”