Chromobacterium violaceum causing deadly sepsis

Sachu, Arun; Antony, Sunil; Mathew, Philip; Sunny, Sanjo; Koshy, Jency Maria; Kumar, Vijaya; Mathew, Robert

doi:10.18502/ijm.v12i4.3941

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…In this study, seven strains of model microorganisms were employed to evaluate the antimicrobial effects of the medicinal plant-derived honey native to China. These pathogens can invade many parts of the human body, such as the intestine, urinary tract and respiratory tract, causing severe systemic infections and even mortality (Gravina et al, 2018;Bretón et al, 2002;Sachu et al, 2020;Sindeldecker and Stoodley, 2021;Tang et al, 2020). Almost all of them have developed multidrug resistance, making clinical therapeutics increasingly difficult (Yang et al, 2014;Krawczyk et al, 2021;Poirel et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS

Lin

Huang

Cheng

et al. 2022

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS

Lin

Huang

Cheng

et al. 2022

Journal of Ethnopharmacology

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“…18 Cases of urinary tract infection because of recurrent use of a catheter in a chronic kidney disease patients have also been reported. 88,109 Two cases of infection were probably acquired through the use of a humidified Venturi mask while in transfer to or from an intensive care ward. 38 Antibiotic susceptibility testing revealed high rate of sensitivity to carbapenems, aminoglycosides, chloramphenicol, quinolones, tetracyclines and trimethoprimsulfamethoxazole.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Chromobacterium violaceum: A Review of an Unexpected Scourge

Alisjahbana¹,

Debora²,

Susandi³

et al. 2021

IJGM

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Chromobacterium violaceum is a common environmental bacterium that rarely causes disease in humans but has a high fatality rate if it does. Due to the rarity of the cases, clinicians are often unaware of the rapid progression of C. violaceum infection and its unexpected antibiotic resistance pattern, which contribute to the failure of patient management. Our review provides the clinical characteristics, possible sources of exposure, and comorbidities and determines factors associated with survival. We gathered information on 132 cases of C. violaceum causing disease in humans published between 1953 and 2020. Patients were predominantly male with a median age of 17.5, interquartile range (IQR) of 5.0-40.0 years, and a third of them were known to have immune deficiencies or comorbidities. Portals of entry were mainly through a wound in the leg and feet (28.0%), the torso (8.5%), or hands and arms (6.8%). It is not uncommon to acquire infection through unintended contact with contaminated water or dust through the mouth or inhalation. The median incubation period is 4.0 days (IQR 2.0-8.0 days) with a duration of clinical course of 17.5 days (IQR 8.0-30.8 days). The high rate of positive blood cultures (56.1%) and abscesses in internal organs (36.4%) shows the significant severity of this disease. Sepsis and Bacteremia were related to mortality with a risk ratio (RR) of 5.20 (95% CI, 0.831-32.58) and 2.14 (95% CI, 1.05-4.36), respectively. Appropriate antibiotic use prevented death at a RR 0.33 (95% CI, 0.21-0.52). Most patients who recovered and survived were treated with aminoglycosides, fluoroquinolones and carbapenems. This review shows the malignant nature of C. violaceum infection and the need for clinicians to be aware and provide prompt source management for patients. Appropriate empiric and targeted antibiotic regiment guided by susceptibility test results is of vital importance.

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“…The association of Chromobacterium violaceum infection with CGD has been previously described, mainly in children since the hereditary nature of the disease and almost none in adults with skin and soft tissue infections [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Nonetheless, this association does not seem to be directly related to an increase in mortality [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Chromobacterium violaceum Periareolar Infection, First Non-Lethal Case in Colombia: Case Report and Literature Review

Díaz

Martin

Ortiz

et al. 2021

Infectious Disease Reports

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Chromobacterium violaceum is a facultative anaerobic, Gram-negative rod found in different ecosystems, especially tropical and subtropical areas. Human infections are rare, and just a few cases have been reported in literature. In this paper, we present the first non-lethal infection due to Chromobacterium violaceum, in an adult male with polycystic kidney disease in Colombia. Periareolar soft tissue infection was documented with isolation of Chromobacterium violaceum. Clinical manifestations, treatment, and outcome are shown.

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Chromobacterium violaceum causing deadly sepsis

Cited by 5 publications

References 13 publications

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS

The in vitro and in vivo antibacterial activities of uniflorous honey from a medicinal plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS

Chromobacterium violaceum: A Review of an Unexpected Scourge

Chromobacterium violaceum Periareolar Infection, First Non-Lethal Case in Colombia: Case Report and Literature Review

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