Chromium picolinate inhibits cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats

Seif, Ansam Aly

doi:10.1007/s11845-014-1102-7

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…The antioxidant and anti-inflammatory activity of CrPic has been studied in some experiments and explainable in many mechanisms, one of them is induced the decreasing of nitrite serum production, which inhibits nitrite reaction with superoxide and reduces peroxynitrite production (Cefalu et al, 2010;Seif, 2015). Similarly to CrYst, yeast contained in the feed was assumed to affect antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Stress responses of transportation on red tilapia which given feed containing chromium

Rakhmawati¹,

Suprayudi

Setiawati

et al. 2018

Jurnal Akuakultur Indonesia

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This study was conducted to evaluate stress responses of transportation on red tilapia Oreochromis sp. which given feed containing chromium. Three isonitrogenous and isocaloric experimental feeds were prepared, these diets were control (without chromium), CrPic 1 mg/kg, and CrYst 2 mg/kg supplementation in feed, all group were arranged triplicate. Satiation feeding was done three times a day. After a 60-day feeding experiment, the experimental fishes were fasted and distributed in polyethylene bags (N=60 fish/bag) containing 3 L of water, subjected to condition of transport simulation for 13 hours. Survival rate, levels of plasma cortisol, blood glucose, superoxide dismutase (SOD), and malondialdehyde (MDA) enzyme were observed at before transportation, after transportation, one day, and two days after transportation. The result showed that chromium supplementation reduced the levels of plasma cortisol before and after transportation, one day, and two days after transportation. Also, it decreased blood glucose compared with control significantly before transportation and one day after transportation. The SOD enzyme concentration increased significantly after fish was fed with feed containing chromium for 30 days, while the MDA enzyme concentration increased significantly after two days of transportation. However, there was no significant difference in the survival of red tilapia between treatments. The best result was obtained in the treatment of fish which fed with feed containing chromium. A 1 mg/kg of CrPic supplementation and 2 mg/kg CrYst increased the body resistance in red tilapia by decreasing the negative effect of stress while transportation.Keywords: stress, transportation, red tilapia, chromium ABSTRAKPenelitian dilakukan untuk mengevaluasi respons stres transportasi ikan nila merah Oreochromis sp. yang diberikan pakan yang mengandung kromium. Pada penelitian ini digunakan tiga jenis pakan, terdiri atas pakan tanpa suplementasi kromium (kontrol), pakan bersuplementasi kromium pikolinat (CrPic 1 mg/kg), dan kromium yeast (CrYst 2 mg/kg), semua perlakuan diulang sebanyak tiga ulangan. Pemberian pakan sebanyak tiga kali sehari dan dilakukan secara at satiation. Setelah 30 hari pemeliharaan, ikan uji dipuasakan dan didistribusikan dalam plastik polietilen (N=60 ekor ikan/kantong plastik) yang berisi 3 L air, dilakukan dengan simulasi transportasi selama 13 jam. Parameter yang diamati pada penelitian ini adalah kelangsungan hidup, kortisol, glukosa darah, enzim superoksida dismustase (SOD), dan malondialdehida (MDA) saat sebelum transportasi, sesaat setelah transportasi, sehari, dan dua hari setelah transportasi. Hasil yang didapatkan adalah suplementasi kromium menurunkan konsentrasi kortisol secara signifikan sebelum transportasi, sesaat, sehari, dan dua hari setelah transportasi. Suplementasi kromium menurunkan glukosa darah secara signifikan pada saat sebelum transportasi dan sehari setelah transportasi. Konsentrasi enzim SOD meningkat secara signifikan setelah pemberian pakan bersuplementasi ...

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Section: Discussionmentioning

confidence: 99%

Stress responses of transportation on red tilapia which given feed containing chromium

Rakhmawati¹,

Suprayudi

Setiawati

et al. 2018

Jurnal Akuakultur Indonesia

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“…Catechin is a polyphenol that is found in apples, citrus fruits, and tea, and promotes weight loss, metabolic syndrome alleviation, and prevention of diabetes and cardiovascular disease . Chromium is an essential trace element that is found in seafood and seaweed, and improves lipid metabolism . Boron is an essential trace element for plants that is present in vegetables at high levels and is found in legumes, fruits, and marine algae .…”

Section: Discussionmentioning

confidence: 99%

“…[20] Chromium is an essential trace element that is found in seafood and seaweed, and improves lipid metabolism. [21] Boron is an essential trace element for plants that is present in vegetables at high levels and is found in legumes, fruits, and marine algae. [22] Boron-containing compounds improve lipid homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Identification of Characteristic Components and Foodstuffs in Healthy Japanese Diet and the Health Effects of a Diet with Increased Use Frequency of these Foodstuffs

Iwagaki

Sakamoto

Sugawara

et al. 2017

Molecular Nutrition Food Res

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“…However, it did not affect carbohydrate metabolism parameters such as FBG, serum insulin concentrations, IR-index and related enzymes (G6PD and GCK level), and other biochemical indices (ALT, AST, ALP, TP, BUN, Crea) in rodents of both gender. Seif [ 72 ] noted that Cr supplementation of hypercholesterolemic rats at a dose of 200 µg/day CrPic for 10 weeks improved their lipid profile and reduced excessive platelet aggregation, mainly by lowering the cholesterol concentration.…”

Section: Discussionmentioning

confidence: 99%

The Interactive Effect of High Doses of Chromium(III) and Different Iron(III) Levels on the Carbohydrate Status, Lipid Profile, and Selected Biochemical Parameters in Female Wistar Rats

2020

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The aim of the study was to evaluate the main and interactive effects of chromium(III) propionate complex (Cr3) supplementation and different iron supply on the carbohydrate metabolism, lipid profile and other selected biochemical parameters of rats. The experiment was carried out in a two-factor design, in which rats were fed a diet with different proportions of Fe(III) and Cr(III) for six weeks. Fifty-four healthy female Wistar rats were divided into nine experimental groups with different Fe(III) levels, i.e. adequate—control group (45 mg/kg)—100% recommended daily dietary dose of Fe for rodents, deficient (5 mg/kg) and oversupply (180 mg/kg—400%). At the same time they were supplemented with Cr(III) of doses 1 (adequate), 50 and 500 mg/kg of diet. The activity and concentrations of most biochemical parameters were measured with standard enzymatic, kinetic, and colorimetric methods. HOMA-IR and QUICKI indexes were calculated according to appropriate formulas. It was found that there was an interactive effect of high Cr(III) doses and different Fe(III) levels in the diet on the carbohydrate metabolism and insulin resistance indexes. The presented results suggested that iron deficient diet fed animals led to insulin resistance; however, an effect is attenuated by Cr(III) supplementation at high doses. There were no significant changes in the rats’ lipid profile (except for the high density lipoprotein cholesterol (HDL-C) level) and most of the other biochemical parameters, such as the leptin, aspartate aminotransferase (AST), alanine transaminase (ALT), total protein (TP), creatinine (Crea) and the urea (BUN) concentrations. The study proved that the Cr(III) supplementation, independently and in combination with diversified Fe(III) content in the diet, affected the carbohydrate metabolism and insulin resistance indexes but did not affect lipid profile and most of the other biochemical parameters in healthy rats. The findings proved the role of Fe and Cr(III) and their interactions on disturbances carbohydrates metabolism.

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Chromium picolinate inhibits cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats

Abstract: Chromium supplementation to hypercholesterolemic rats improves the lipid profile and returns platelet hyperaggregability to control levels. This normalization is mostly due to a reduction in plasma cholesterol level.

Cited by 12 publications

References 27 publications

Stress responses of transportation on red tilapia which given feed containing chromium

Stress responses of transportation on red tilapia which given feed containing chromium

Identification of Characteristic Components and Foodstuffs in Healthy Japanese Diet and the Health Effects of a Diet with Increased Use Frequency of these Foodstuffs

The Interactive Effect of High Doses of Chromium(III) and Different Iron(III) Levels on the Carbohydrate Status, Lipid Profile, and Selected Biochemical Parameters in Female Wistar Rats

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