Chromium downregulates the expression of Acetyl CoA Carboxylase 1 gene in lipogenic tissues of domestic goats: a potential strategy for meat quality improvement

Najafpanah, Mohammad Javad; Sadeghi, Mostafa; Zali, A.; Moradi-Shahrebabak, Hossein; Mousapour, Hojatollah

doi:10.1016/j.gene.2014.04.006

Cited by 15 publications

(10 citation statements)

References 35 publications

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“…Supplementing goats with Cr decreased the expression level of ACACA, FASN , and FABP4 (Sadeghi et al, 2015) as measured by RT-PCR. Furthermore, increased Longissimus muscle area and reduced fat thickness was associated with a downregulation of ACACA expression in Cr-supplemented goats (Najafpanah et al, 2014). It seems to follow that Cr supplementation can improve meat quality by altering the direction of energy accumulation from fat deposition toward muscle growth in goats (Najafpanah et al, 2014; Sadeghi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, increased Longissimus muscle area and reduced fat thickness was associated with a downregulation of ACACA expression in Cr-supplemented goats (Najafpanah et al, 2014). It seems to follow that Cr supplementation can improve meat quality by altering the direction of energy accumulation from fat deposition toward muscle growth in goats (Najafpanah et al, 2014; Sadeghi et al, 2015). Cr-supplemented Angus-cross steers were also found with increased Longissimus muscle area and decreased IMF without affecting growth performance (Kneeskern et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

et al. 2019

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Meat quality is a complex trait that is influenced by genetic and environmental factors, which includes mineral concentration. However, the association between mineral concentration and meat quality, and the specific molecular pathways underlying this association, are not well explored. We therefore analyzed gene expression as measured with RNA-seq in Longissimus thoracis muscle of 194 Nelore steers for association with three meat quality traits (intramuscular fat, meat pH, and tenderness) and the concentration of 13 minerals (Ca, Cr, Co, Cu, Fe, K, Mg, Mn, Na, P, S, Se, and Zn). We identified seven sets of co-expressed genes (modules) associated with at least two traits, which indicates that common pathways influence these traits. From pathway analysis of module hub genes, we further found an over-representation for energy and protein metabolism (AMPK and mTOR signaling pathways) in addition to muscle growth, and protein turnover pathways. Among the identified hub genes FASN, ELOV5, and PDE3B are involved with lipid metabolism and were affected by previously identified eQTLs associated to fat deposition. The reported hub genes and over-represented pathways provide evidence of interplay among gene expression, mineral concentration, and meat quality traits. Future studies investigating the effect of different levels of mineral supplementation in the gene expression and meat quality traits could help us to elucidate the regulatory mechanism by which the genes/pathways are affected.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

et al. 2019

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“…Perhaps the supplements are enabling fatty acid mobilization from subcutaneous fat depots over internal fat depots. Many compounds have induced different changes in subcutaneous and visceral depots [ 20 , 32 – 37 ] and some of these compounds are contained in the thermogenic supplement in the present study [ 20 , 34 , 35 ]. For example, Maki and colleagues demonstrated that individuals who supplemented with green tea significantly reduced their subcutaneous fat compared to control (p < 0.019), whereas intra-abdominal fat was not significantly reduced (p < 0.05) [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous and Segmental Fat Loss with and without Supportive Supplements in Conjunction with a Low-Calorie High Protein Diet in Healthy Women

et al. 2015

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BackgroundWeight loss benefits of multi-ingredient supplements in conjunction with a low-calorie, high-protein diet in young women are unknown. Therefore, the purpose of this study was to investigate the effects of a three-week low-calorie diet with and without supplementation on body composition.MethodsThirty-seven recreationally-trained women (n = 37; age = 27.1 ± 4.2; height = 165.1 ± 6.4; weight = 68.5 ± 10.1; BMI = 25.1 ± 3.4) completed one of the following three-week interventions: no change in diet (CON); a high-protein, low-calorie diet supplemented with a thermogenic, conjugated linoleic acid (CLA), a protein gel, and a multi-vitamin (SUP); or the high-protein diet with isocaloric placebo supplements (PLA). Before and after the three-week intervention, body weight, %Fat via dual X-ray absorptiometry (DXA), segmental fat mass via DXA, %Fat via skinfolds, and skinfold thicknesses at seven sites were measured.ResultsSUP and PLA significantly decreased body weight (SUP: PRE, 70.47 ± 8.01 kg to POST, 67.51 ± 8.10 kg; PLA: PRE, 67.88 ± 12.28 kg vs. POST, 66.38 ± 11.94 kg; p ≤ 0.05) with a greater (p ≤ 0.05) decrease in SUP than PLA or CON. SUP and PLA significantly decreased %Fat according to DXA (SUP: PRE, 34.98 ± 7.05% to POST, 32.99 ± 6.89%; PLA: PRE, 34.22 ± 6.36% vs. POST, 32.69 ± 5.84%; p ≤ 0.05), whereas only SUP significantly decreased %Fat according to skinfolds (SUP: PRE, 27.40 ± 4.09% to POST, 24.08 ± 4.31%; p ≤ 0.05). SUP significantly (p ≤ 0.05) decreased thicknesses at five skinfolds (chest, waist, hip, subscapular, and tricep) compared to PLA, but not at two skinfolds (axilla and thigh).ConclusionsThe addition of a thermogenic, CLA, protein, and a multi-vitamin to a three-week low-calorie diet improved weight loss, total fat loss and subcutaneous fat loss, compared to diet alone.

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“…ACC‐α (or ACACA), which is the rate‐limiting enzyme in the biogenesis of long‐chain fatty acid, converts acetyl‐CoA to malonyl‐CoA and ACC‐β (or ACACB). It also stimulates the process to generate malonyl‐CoA and control mitochondrial fatty acid oxidation (Moibi and others ; Najafpanah and others ). ACC affects the biosynthesis of palmitic acid and long‐chain fatty acids, being one of the most important enzymes involved in the synthesis of SFAs (Garcia‐Fernandez and others ).…”

Section: Gene Expression Of the Long‐chain Pufasmentioning

confidence: 99%

Manipulation of Omega‐3 PUFAs in Lamb: Phenotypic and Genotypic Views

Alvarenga

Garcia

Pérez

et al. 2015

Comp Rev Food Sci Food Safe

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A number of studies have shown that dietary omega-6 and omega-3 long-chain fatty acids can be incorporated into muscle tissue of ruminants despite the biohydrogenation of dietary fatty acids in the rumen. The main focus of this review is on eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) fatty acids because health authorities around the world consider the sum of these fatty acids as the basis of classifying a food as a source or good source of omega-3 polyunsaturated fatty acids (PUFAs). A high proportion of polyunsaturated fatty acids are hydrogenated in the rumen, leading to a higher concentration of 18:0, but some escapes the rumen to be absorbed intact by the small intestine. Feeding strategies for ruminants have been successfully applied to increase the absorption of PUFAs in the small intestine and therefore to increase the levels of PUFAs in muscle tissue. Protected fats and algae are strong candidates to improve the nutritional value of red meat in ruminants in terms of health-claimable omega-3 fatty acids. Efforts to understand the genetic basis of fatty acid metabolism have been underway. The knowledge of the main genes which control the output of omega-3 fatty acids is still lacking, but gene expression studies have helped to explain the deposition of these acids in muscle, liver, and subcutaneous fat.

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Chromium downregulates the expression of Acetyl CoA Carboxylase 1 gene in lipogenic tissues of domestic goats: a potential strategy for meat quality improvement

Cited by 15 publications

References 35 publications

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle

Subcutaneous and Segmental Fat Loss with and without Supportive Supplements in Conjunction with a Low-Calorie High Protein Diet in Healthy Women

Manipulation of Omega‐3 PUFAs in Lamb: Phenotypic and Genotypic Views

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