Chromium and Parenteral Nutrition in Children

Bouglé, Dominique; Bureau, F.; Deschrevel, G; Hecquard, C.; Neuville, Dominique; Drosdowsky, M. A.; Duhamel, J.F.

doi:10.1097/00005176-199307000-00010

Cited by 24 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with reports of previous researchers, we found that the affected infants were more immature Early amino-acid support and cholestasis M Steinbach et al and had lower birth weight than the non-affected group. 5,[7][8][9] Other investigations have also described an association between cholestasis and the quantity and formulation of amino acids administered parenterally, excess caloric intake of fats and carbohydrates, 10,11 toxicity of trace minerals, [12][13][14][15][16] male gender, 17 perinatal asphyxia, 18 phototoxicity of multivitamin 2 Aggressive administration of parenteral amino acids to improve protein accretion rates in very preterm neonates has been supported in the literature. [24][25][26][27] Although tolerance of high-dose amino acids has been described, researchers acknowledge that sensitive tests to monitor amino-acid toxicity are not readily available in the clinical setting.…”

Section: Discussionmentioning

confidence: 99%

Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant

et al. 2007

View full text Add to dashboard Cite

Objective: The primary aim of this study was to determine if an association exists between amino-acid levels and development of cholestasis. The secondary aim of our amino-acid dose comparison trial was to identify factors associated with the development of prolonged cholestatic jaundice.Study Design: We compared demographic characteristics and amino-acid levels in neonates who developed cholestasis with those who did not. Parenteral-associated cholestatic liver disease was defined as a direct serum bilirubin above 5 mg per 100 ml any time during the first 28 days after birth in neonates with no history of biliary atresia or viral hepatitis. We obtained filter paper blood spots for amino acid and acylcarnitine measurements on the day of randomization and days 7 and 28 of age to identify a profile of values that could be used to identify neonates with evidence of abnormal liver function. Result:We enrolled 122 neonates in our study; 13 (10.7%) developed cholestasis. Neonates who developed cholestasis were more immature, had lower birth weight, were exposed to parenteral nutrition for a longer period, had a higher cumulative dose of amino acids, were less often on enteral nutrition by day 7 of age, more often had a patent ductus arteriosus and severe intraventricular hemorrhage and were more commonly treated with steroids by 28 days of age. Amino acid and acylcarnitine values were not different for the two groups on the day of randomization. On day 7 (parenteral phase of nutrition), blood urea nitrogen, citrulline, histidine, methionine and succinyl carnitine were higher, and serine, glutamate and thyroxine levels were lower in the neonates who developed cholestasis than in who did not. Conclusion:Cholestasis remains an important complication of parenteral nutrition, and several clinical and biochemical factors may be helpful in identifying high-risk patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This effect on iron status has also been observed in humans. In children receiving total parenteral nutrition, higher Cr serum levels correlated with lower serum iron levels [120]. Men in a weight training program who were given chromium picolinate supplements showed a 24% decrease in transferrin saturation, compared to a 10-13% decrease for those given chromic chloride or a placebo [106].…”

Section: Is Chromium Metabolism Related To Iron Metabolism?mentioning

confidence: 90%

Is chromium a trace essential metal?

Stearns

2000

BioFactors

127

View full text Add to dashboard Cite

If chromium is an essential metal it must have a specific role in an enzyme or cofactor, and a deficiency should produce a disease or impairment of function. To date, no chromium-containing glucose tolerance factor has been characterized, the purpose of the low-molecular-weight chromium-binding protein is questionable, and no direct interaction between chromium and insulin has been found. Furthermore, chromium3+ is treated like the toxic metals arsenic, cadmium, lead and mercury in animals. Chromium3+ may be involved in chromium6+-induced cancers because chromium6+ is converted to chromium3+ in vivo, and chromium3+ is genotoxic and mutagenic. Although there is no direct evidence of chromium deficiencies in humans, dietary supplements exist to provide supraphysiological doses of absorbable chromium3+. Chromium3+ may act clinically by interfering with iron absorption, decreasing the high iron stores that are linked to diabetes and heart disease. If so, this would make chromium3+ a pharmacological agent, not an essential metal.

show abstract

“…14,15 However, in children receiving parenteral nutrition, although elevated serum Cr was shown to correlate inversely with serum Fe, hemoglobin values did not diminish. 16 We are aware of a single animal study that found anemia that ameliorated with time with exposure to Cr. 17 Anemia from Pb or arsenic exposure is well documented.…”

Section: Discussionmentioning

confidence: 99%

An Investigation of Aircraft Worker Anemia

Muller

Allstadt²,

Rennix³

et al. 2011

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

Anemia may be more prevalent in middle-aged workers than expected. Modern laboratories generally report a calculated hematocrit value, and using hemoglobin for most classification purposes is preferred. Characteristics of a specific workforce, including age, health, hobbies, and diet, should be taken into account when interpreting medical surveillance program findings. The value of a team approach in addressing occupational health problems was demonstrated.

show abstract

Chromium and Parenteral Nutrition in Children

Cited by 24 publications

References 0 publications

Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant

Demographic and nutritional factors associated with prolonged cholestatic jaundice in the premature infant

Is chromium a trace essential metal?

An Investigation of Aircraft Worker Anemia

Contact Info

Product

Resources

About