Chromatographic separation of selenium and arsenic: A potential 72Se/72As generator

Abstract

Summary An anion exchange method was developed to separate selenium and arsenic for potential utility in a 72Se/72As generator. The separation of the daughter 72As from the 72Se parent is based on the relative acid-base behavior of the two oxo-anions in their highest oxidation states. At pH 1.5, selenate is retained on strongly basic anion exchange resin as HSeO4− and SeO42−, while neutral arsenic acid, H3AsO4, is eluted.

Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals

“…Arsenic-72 is a 26 h positron emitter for which development of a 72 Se/ 72 As generator has been reported, potentially leading to portable availability of this PET radionuclide [2–6]. Arsenic-77 is a 38.8 h beta emitter that is reactor produced through neutron irradiation of enriched 76 GeO 2 followed by beta decay of 77 Ge (11.3 h).…”

Radionuclide candidates for β+γ coincidence PET: An overview

“…There are many methods for the direct production of 72 As, however much more attention is paid to the generator 72 Se/ 72 As due to its convenient half-life of 8.4 d. Many practical extraction methods for this generator have already been reported (Al- Kouraishi and Boswell, 1978;Phillips et al, 1991;Jennewein et al, 2004Jennewein et al, , 2005Ballard et al, 2012Ballard et al, , 2012bChajduk et al, 2012;Wycoff et al, 2014;Feng et al, 2019). According to the literature, the best method for the production of 72 Se/ 72 As leads via 70 Ge( ⍺ ,2n) reaction (Amiel, 1959;Al-Kouraishi and Boswell, 1978;Calboreanu et al, 1987;Mushtaq and Qaim, 1990;Levkovskij, 1991;Jennewein et al, 2005;Szkliniarz et al, 2015;Takács et al, 2016;Feng et al, 2019).…”

Labelling with positron emitters of pnicogens and chalcogens

“…The radionuclide 72 As can be produced directly via various nuclear reactions; particularly noteworthy are the 72 Ge(p,n) 72 As and 72 Ge(d,2n) 72 As reactions at low‐energy cyclotrons. An alternative availability is the indirect way as a daughter radionuclide of the relatively long‐lived 72 Se using a generator system . Selenium‐72 can be produced via various charged particle reactions on Ge, Br, or As targets, the most common routes being the 70 Ge(α,2n) 72 Se or 75 As(p,4n) 72 Se reaction, which are feasible only at multiparticle and intermediate‐energy cyclotrons …”

“…An alternative availability is the indirect way as a daughter radionuclide of the relatively long-lived 72 Se using a generator system. [92][93][94] Selenium-72 can be produced via various charged particle reactions on Ge, Br, or As targets, the most common routes being the 70 Ge(α,2n) 72 Se or 75 As(p,4n) 72 Se reaction, which are feasible only at multiparticle and intermediate-energy cyclotrons. 95,96 The production of 74 As can be realized best using the 74 Ge(p,n) 74 As or 73 Ge(d,n) 74 As reaction at a small-sized cyclotron.…”