Chromatographic behaviour of positional isomers on porous graphitic carbon

Wan, Qian; Shaw, P. Nicholas; Davies, Martyn C.; Barrett, David A.

doi:10.1016/0021-9673(94)00813-o

Cited by 61 publications

(22 citation statements)

References 10 publications

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“…It is an extremely strong adsorbent, because of the occurrence of large dispersion forces between the solute and the rigid planar graphite surface. PGC strongly retains polar solutes, mainly because of specific interactions with the electronic structure of the graphite, although the retention mechanism is still open to discussion [15,20,21]. The effects of temperature on the retention of natural cyclodextrins on PGC with methanolwater mobile phases have recently been reported; these results demonstrate the occurrence of a double-retention mechanism for solutes on a PGC stationary phase [21].…”

Section: Introductionmentioning

confidence: 88%

Chromatographic study of terpene-β-cyclodextrin complexes on porous graphitic carbon stationary phase

et al. 2001

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SummaryThe effect of temperature on the retention of terpene derivatives on a porous graphitic carbon stationary phase has been investigated with methanol-water mobile phases containing fl-cyclodextrin. Changes in Van't Hoff plots were evaluated in relation to the fl-cyclodextrin concentration. Thermodynamic data were determined for both (i) solute transfer from the mobile phase to the PGC stationary phase and (ii) complexation of the solute with the fl-CD. Enthalpyentropy compensation studies were performed for these I',,vo processes. Solute transfer was shown to be enthalpically driven and independent of terpene structure, fl-cyclodextrin concentration, and mobile phase methanol content. The complexation reaction was shown to be entropically controlled and independent of terpene structure and mobile-phase composition.Comparison of the compensation temperatures of these I',,vo physicochemical processes led to the conclusion that each process had an similar influence on the global retention process.

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Section: Introductionmentioning

confidence: 88%

Chromatographic study of terpene-β-cyclodextrin complexes on porous graphitic carbon stationary phase

et al. 2001

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“…Carbon stationary phases have been used to separate carbohydrate isomers [40], di-substituted benzene isomers [41] and alkylglycoside detergents [42] under RPLC conditions. Similarly, carboxylate-PGC was shown to have an isomeric selectivity (e.g., cytosine/isocytosine and salicyluric acid/␣-hydroxyhippuric acid pairs) [4].…”

Section: Isomeric Selectivity Of the Hybrid Carbon-silica Phasementioning

confidence: 99%

Hybrid carbon nanoparticles modified core–shell silica: A high efficiency carbon-based phase for hydrophilic interaction liquid chromatography

Ibrahim

Wahab

Lucy

2014

Analytica Chimica Acta

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“…Seven silica-based columns with wide pH range or different selectivities and one porous graphitized carbon were chosen. Several studies have presented the Hypercarb column as helpful in pharmaceutical analysis, not only for basic compounds but also for polar and closely related compounds [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Development of an HPLC Method for Determination of Related Impurities in Prilocaine Substance

et al. 2012

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Development of a reversed phase high performance liquid chromatographic method for determination of six related impurities in prilocaine substance is reported. The test of related impurities in European Pharmacopoeia (Ph. Eur.) cannot meet the demands with the chromatographic parameters given, therefore different types of chromatographic systems and eight columns have been evaluated in the present study. A new method with a Hypercarb column was developed and validated. This method fulfils the demands in the Ph. Eur., and the validation shows that the method is selective, reproducible, linear, accurate and robust with sufficient limits of detection (0.001-0.004% of 2.5 mg prilocaine mL -1 ) and quantification (0.002-0.009% of 2.5 mg prilocaine mL -1 ).

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Chromatographic behaviour of positional isomers on porous graphitic carbon

Cited by 61 publications

References 10 publications

Chromatographic study of terpene-β-cyclodextrin complexes on porous graphitic carbon stationary phase

Chromatographic study of terpene-β-cyclodextrin complexes on porous graphitic carbon stationary phase

Hybrid carbon nanoparticles modified core–shell silica: A high efficiency carbon-based phase for hydrophilic interaction liquid chromatography

Development of an HPLC Method for Determination of Related Impurities in Prilocaine Substance

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