Chromatin modifications during X-chromosome inactivation in female mammals

Shevchenko, Alexander I.; Павлова, С. В.; Дементьева, Е. В.; Golubeva, D V; Закиян, С М

doi:10.1134/s1022795406090080

Cited by 9 publications

(7 citation statements)

References 65 publications

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“…Subsequently, either the paternal or the maternal Xchromosome is randomly chosen to be inactivated (Mak et al 2004;Okamoto et al 2004). Both random and imprinted XCI in eutherians is triggered by upregulation of the X inactive specific transcript (Xist) gene on the future inactive X-chromosome (Xi; Heard 2005;Heard and Disteche 2006;Shevchenko et al 2006).…”

Section: Communicated By E Niggmentioning

confidence: 99%

Difference between random and imprinted X inactivation in common voles

et al. 2010

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During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance.

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Section: Communicated By E Niggmentioning

confidence: 99%

Difference between random and imprinted X inactivation in common voles

et al. 2010

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“…It is known that the Xi of eutherian mammals is depleted in the histone markers associated with transcriptionally active chromatin (Heard et al 2001;Boggs et al 2002;Okamoto et al 2004;Shevchenko et al 2006Shevchenko et al , 2009. We have demonstrated that the M. domestica inactive X chromosome is hypomethylated at H3K4 and hypoacetylated at H3K9.…”

Section: Discussionmentioning

confidence: 93%

“…It is known that the inactive X chromosome of humans, mice, and other eutherians displays decreased levels of active chromatin modifications (Heard et al 2001;Boggs et al 2002;Okamoto et al 2004;Shevchenko et al 2006Shevchenko et al , 2009. Depletion in the modifications was also observed on the Xi in M. eugenii (Wakefield et al 1997;Koina et al 2009).…”

Section: The Modifications Characteristic Of Active Chromatinmentioning

confidence: 87%

“…The histone H3 trimethylations at lysines 9 and 27 (H3K9me3 and H3K27me3) are known as modifications attributable to transcriptionally inactive chromatin, which is involved in Xchromosome inactivation in eutherian mammals (Chadwick and Willard 2004;Heard 2005;Shevchenko et al 2006Shevchenko et al , 2009. As for marsupials, the M. eugenii metaphase Xi and Xa do not differ in the distributions of H3K9me3 and H3K27me3; the heterochromatic regions on the short arms of both X chromosomes contain H3K9me3, whereas the long arms, which contain the regions homologous to the human X chromosome, display H3K27me3 (Koina et al 2009); however, in M. domestica interphase nuclei, the Xi was enriched in H3K27me3 (Mahadevaiah et al 2009).…”

Section: The Modifications Characteristic Of Inactive Chromatinmentioning

confidence: 99%

“…The Xi of eutherian mammals is depleted of the histone modifications attributable to transcriptionally active chromatin and enriched in those specific to inactive chromatin (see Heard 2005). It is known that the facultative heterochromatin in the human, bovine, and vole inactive X chromosome is represented by two distinct non-overlapping types differing in repressive histone modifications (Chadwick and Willard 2004;Chadwick 2007;Coppola et al 2008;Shevchenko et al 2006;Shevchenko et al 2009). Characteristic of the first type is H3K27 trimethylation (H3K27me3) while the second type is associated with H3K9 (H3K9me3) and H4K20 trimethylation.…”

Section: Introductionmentioning

confidence: 98%

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Histone H3 trimethylation at lysine 9 marks the inactive metaphase X chromosome in the marsupial Monodelphis domestica

et al. 2010

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In somatic cells of female marsupial and eutherian mammals, X chromosome inactivation (XCI) occurs. XCI results in the transcriptional silencing of one of the two X chromosomes and is accompanied by specific covalent histone modifications attributable to the inactive chromatin state. Because data about repressed chromatin of the inactive X chromosome (Xi) in marsupials are sparse, we examined in more detail the distribution of active and inactive chromatin markers on metaphase X chromosomes of an American marsupial, Monodelphis domestica. Consistent with data reported previously both for eutherian and marsupial mammals, we found that the Xi of M. domestica lacks active histone markers-H3K4 dimethylation and H3K9 acetylation. We did not observe on metaphase spreads enrichment of the Xi with H3K27 trimethylation which is involved in XCI in eutherians and was detected on the Xi in the interphase nuclei of mature female M. domestica in an earlier study. Moreover, we found that the Xi of M. domestica was specifically marked with H3K9 trimethylation, which is known to be a component of the Xi chromatin in eutherians and is involved in both marsupials and eutherians in meiotic sex chromosome inactivation which has been proposed as an ancestral mechanism of XCI.

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X‐chromosome upregulation and inactivation: two sides of the dosage compensation mechanism in mammals

2009

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Mammals have a very complex, tightly controlled, and developmentally regulated process of dosage compensation. One form of the process equalizes expression of the X-linked genes, present as a single copy in males (XY) and as two copies in females (XX), by inactivation of one of the two X-chromosomes in females. The second form of the process leads to balanced expression between the X-linked and autosomal genes by transcriptional upregulation of the active X in males and females. However, not all X-linked genes are absolutely balanced. This review is focused on the recent advances in studying the dosage compensation phenomenon in mammals.

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Chromatin modifications during X-chromosome inactivation in female mammals

Cited by 9 publications

References 65 publications

Difference between random and imprinted X inactivation in common voles

Difference between random and imprinted X inactivation in common voles

Histone H3 trimethylation at lysine 9 marks the inactive metaphase X chromosome in the marsupial Monodelphis domestica

X‐chromosome upregulation and inactivation: two sides of the dosage compensation mechanism in mammals

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