Chromatic Induction in Migraine

Cerda-Company, Xim; Penacchio, Olivier; Otazu, Xavier

doi:10.3390/vision5030037

Cited by 2 publications

(2 citation statements)

References 48 publications

(70 reference statements)

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“…Since visual stimulus downregulates GABAergic neurotransmitters in a concentration-dependent manner, lactate levels in the occipital brain of MWA are elevated in response to the visual stimulations. Maybe because of the biochemical correlation of impaired inhibitory mechanisms that could be lactate-induced downregulation of GABA activity in the occipital cortex [ 69 ], greater GABA levels are linked with a higher migraine burden [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of Habituation in Migraine Patients Based on High-Density EEG Analysis Using the Steady State of Visual Evoked Potential

Abdulhussein

Alyasseri

Mohammed

et al. 2022

Entropy

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Migraine is a periodic disorder in which a patient experiences changes in the morphological and functional brain, leading to the abnormal processing of repeated external stimuli in the inter-ictal phase, known as the habituation deficit. This is a significant feature clinically of migraine in both two types with aura or without aura and plays an essential role in studying pathophysiological differences between these two groups. Several studies indicated that the reason for migraine aura is cortical spreading depression (CSD) but did not clarify its impact on migraine without aura and lack of habituation. In this study, 22 migraine patients (MWA, N = 13), (MWoA, N = 9), and healthy controls (HC, N = 19) were the participants. Participants were exposed to the steady state of visual evoked potentials also known as (SSVEP), which are the signals for a natural response to the visual motivation at four Hz or six Hz for 2 s followed by the inter-stimulus interval that varies between 1 and 1.5 s. The order of the temporal frequencies was randomized, and each temporal frequency was shown 100 times. We recorded from 128 customized electrode locations using high-density electroencephalography (HD-EEG) and measured amplitude and habituation for the N1–P1 and P1–N2 from the first to the sixth blocks of 100 sweep features in patients and healthy controls. Using the entropy, a decrease in amplitude and SSVEP N1-P1 habituation between the first and the sixth block appeared in both MWA and MWoA (p = 0.0001, Slope = −0.4643), (p = 0.065, Slope = 0.1483), respectively, compared to HC. For SSVEP P1–N2 between the first and sixth block, it is varied in both MWA (p = 0.0029, Slope = −0.3597) and MWoA (p = 0.027, Slope = 0.2010) compared to HC. Therefore, migraine patients appear amplitude decrease and habituation deficit but with different rates between MWA, and MWoA compared to HCs. Our findings suggest this disparity between MWoA and MWA in the lack of habituation and amplitude decrease in the inter-ictal phase has a close relationship with CSD. In light of the fact that CSD manifests during the inter-ictal phase of migraine with aura, which is when migraine seizures are most likely to occur, multiple researchers have lately reached this conclusion. This investigation led us to the conclusion that CSD during the inter-ictal phase and migraine without aura are associated. In other words, even if previous research has not demonstrated it, CSD is the main contributor to both types of migraine (those with and without aura).

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Section: Discussionmentioning

confidence: 99%

Lack of Habituation in Migraine Patients Based on High-Density EEG Analysis Using the Steady State of Visual Evoked Potential

Abdulhussein

Alyasseri

Mohammed

et al. 2022

Entropy

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“…Visual stimuli have been found to decrease the activity of GABAergic neurotransmitters in a concentration-dependent manner [55]. As a result, lactate levels in the occipital region of the brain in individuals with MWA are elevated in response to visual stimulation.…”

Section: Discussionmentioning

confidence: 99%

Differential Cortical Connectivity in Migraine: Insights from High-Density EEG and Steady-State Visual Evoked Potentials

Abdulhussein,

Aldeen,

Al-Abboodi

2024

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This investigation explores cortical connectivity in individuals diagnosed with migraine, employing high-density electroencephalography (HD-EEG) and steady-state visual evoked potentials (SSVEP) to discern distinctions between migraine with aura (MWA) and migraine without aura (MWoA). The cohort comprised 22 participants suffering from migraines, categorized into MWA (13 participants, including 7 females) and MWoA (9 participants, with 5 females), alongside a control group of 19 healthy individuals (8 females), exhibiting no history of migraines. The ages of the migraine and control groups were 29±1 and 27±1 years, respectively. The methodology involved exposing subjects to visual stimuli at frequencies of four Hz and six Hz, each for a duration of 2 seconds, interspersed with interstimulus intervals of 1 to 1.5 seconds. The frequencies were presented in a randomized sequence, with each being delivered 100 times. Through the acquisition of EEG data from 128 custom electrode positions, inter-and intra-hemispheric coherence during the interictal phase was meticulously analyzed. It was observed that individuals with migraines exhibited a pronounced reduction in alpha-wave pattern uniformity across both intra-and interhemispheric connections, a phenomenon markedly accentuated in the MWA group. Further, a unique functional connectivity metric derived from HD-EEG data during repeated SSVEP stimulation emerged as a potential biomarker capable of differentiating between MWA and MWoA subjects. Notably, a significant discrepancy in the slope between Block 1 and Block 6 was observed in MWA subjects, highlighting a distinct response irrespective of stimulation frequency. These findings underscore the clinical significance of cortical connectivity measures in understanding migraine pathophysiology and developing targeted treatments. The variation in alpha-band coherence could reflect differential sensory processing and neural communication mechanisms, potentially linked to Cortical Spreading Depression (CSD). Despite the promising insights, the limited sample size underscores the need for cautious interpretation of the results and further research. This study contributes to the body of knowledge on migraine-induced alterations in brain function, paving the way for refined diagnostic and therapeutic strategies.

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Chromatic Induction in Migraine

Cited by 2 publications

References 48 publications

Lack of Habituation in Migraine Patients Based on High-Density EEG Analysis Using the Steady State of Visual Evoked Potential

Lack of Habituation in Migraine Patients Based on High-Density EEG Analysis Using the Steady State of Visual Evoked Potential

Differential Cortical Connectivity in Migraine: Insights from High-Density EEG and Steady-State Visual Evoked Potentials

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