Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells

Hofer, Doris; Schwach, Gert; Ghaffari-Tabrizi-Wizsy, Nassim; Sadjak, A.; Sturm, Sonja; Stuppner, Hermann; Pfragner, Roswitha

doi:10.3892/or.2013.2367

Cited by 23 publications

(16 citation statements)

References 20 publications

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“…Mariposa christia vespertilionis or also known as Rerama leaf is recently gained attention on its potentials to cure cancer. A decoction of the plant leaves is believed use as remedies or traditional medicine, anti-plasmodium and high cytotoxicity against Hela and MRC54 ( 1 ), inhibits neuroendocrine tumours ( 2 ) and inhibits growth of S180 tumour and H22 tumour cells ( 3 ). Although several pharmacological studies (as antiplasmodial, anti-tumour) have been carried out on this plant, there is no experimental evidence on its toxicity.…”

Section: Introductionmentioning

confidence: 99%

Subacute Oral Toxicity Assesment of Ethanol Extract ofMariposa christia vespertilionisLeaves in Male Sprague Dawley Rats

et al. 2018

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The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL). In this study, a total of 30 rats were divided into the control, 5% DMSO (vehicle), low dose (75 mg/kg), medium dose (125 mg/kg) and high dose (250 mg/kg) groups. The extract was administered daily from day 1 until day 28. At the end of the study, the animals were humanely sacrificed and assessed for the effect extract of Mariposa christia vespertilionis leaves on body weight and relative organ weights and haematological, biochemical and histopathological parameters. The haematological and serum biochemical parameters for the assessment of kidney and liver injuries were carried out. Results of haematological and serum biochemistry results showed no changes in the control and treated groups. In the histopathology, evaluation of kidney tissues in all treated groups showed no significant (p > 0.05) lesions. In contrast to kidney, liver tissues showed significant differences (p < 0.05) in lesions observed in low dose (430 mg), medium dose (700 mg) and high dose (1480 mg) groups with very mild, mild and mild to moderate lesion of hepatic necrosis, in the respective groups, and very mild hepatic degeneration and hepatitis were scored in all three groups.

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Section: Introductionmentioning

confidence: 99%

Subacute Oral Toxicity Assesment of Ethanol Extract ofMariposa christia vespertilionisLeaves in Male Sprague Dawley Rats

et al. 2018

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“…Moreover, plant-based bioactive phytochemicals are capable of inhibiting tumor cytogenesis through various means by inhibition or modification of epigenetic processes which suppresses gene initiation, suppression and progression [6]. In this regard, compounds such as polyphenols, terpenoids and alkaloids reported in plant extracts are mostly seen to demonstrate anti-proliferative and anti-cancer properties [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Christia vespertilionis Root and Leaf Extracts and Fractions against Breast Cancer Cell Lines

et al. 2020

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Christia vespertilionis, commonly known as ‘Daun Rerama’, has recently garnered attention from numerous sources in Malaysia as an alternative treatment. Its herbal decoction was believed to show anti-inflammatory and anti-cancer effects. The present study investigated the cytotoxicity of the extract of root and leaf of C. vespertilionis. The plant parts were successively extracted using the solvent maceration method. The most active extract was further fractionated to afford F1–F8. The cytotoxic effects were determined using MTT assay against human breast carcinoma cell lines (MCF-7 and MDA-MB-231). The total phenolic content (TPC) of the extracts were determined. The antioxidant properties of the extract were also studied using DPPH and β-carotene bleaching assays. The ethyl acetate root extract demonstrated selective cytotoxicity especially against MDA-MB-231 with the highest TPC and antioxidant properties compared to others (p < 0.05). The TPC and antioxidant results suggest the contribution of phenolic compounds toward its antioxidant strength leading to significant cytotoxicity. F3 showed potent cytotoxic effects while F4 showed better antioxidative strength compared to others (p < 0.05). Qualitative phytochemical screening of the most active fraction, F3, suggested the presence of flavonoids, coumarins and quinones to be responsible toward the cytotoxicity. The study showed the root extracts of C. vespertilionis to possess notable anti-breast cancer effects.

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“…Christia vespertilionis or butterfly wing plant is an herbaceous perennial plant and can be categorized as an ornamental plant [1]. The plant has very unique trifoliate leaves shaped and contains promising anti-inflammatory and anticancer properties [2]; [3].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Sexual and Vegetative Propagation of Medicinal Plant Christia vespertilionis (Butterfly Wing Plant)

Shah¹,

Rahman²,

Nawi³

et al. 2020

Proceedings of the 5th International Conference on Food, Agriculture and Natural Resources (FANRes 2019)

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Christia vespertilionis also known as butterfly wing plant is an ornamental and valuable medicinal plant grown in tropical and subtropical regions. Despite the importance, not much attention has been given to study economical propagation methods of C. vespertilionis. This work aims to evaluate between sexual (seeds) and vegetative (cuttings and in vitro) propagation techniques in terms of their viability and growth. Pretreatment of seeds showed that wet paper towel was observed induced a higher percentage of germination rate as compared to other treatments. A comparison between two types of cuttings indicated semi hardwood part propagated better than the softwood part. In the present study, in vitro shoot proliferation was obtained by culturing nodal node segments in Murashige and Skoog (MS) medium supplemented with 2.0 mg/L of 6-Benzyl amino purine (BAP). However, no root development was observed when well-developed shoots were transferred on rooting medium supplemented with various concentrations of Indolebutyric acid (IBA). We conclude that C. vespertilionis appear to propagate easily using seeds and semi-woody cuttings. Further investigation of in vitro propagation could potentially be used for future conservation and sustainable production of C. vespertilionis.

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Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells

Cited by 23 publications

References 20 publications

Subacute Oral Toxicity Assesment of Ethanol Extract ofMariposa christia vespertilionisLeaves in Male Sprague Dawley Rats

Subacute Oral Toxicity Assesment of Ethanol Extract ofMariposa christia vespertilionisLeaves in Male Sprague Dawley Rats

Cytotoxic Activity of Christia vespertilionis Root and Leaf Extracts and Fractions against Breast Cancer Cell Lines

The Evaluation of Sexual and Vegetative Propagation of Medicinal Plant Christia vespertilionis (Butterfly Wing Plant)

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