Choroidopathy after blunt trauma to the eye: a fluorescein and indocyanine green angiographic study

Kohno, Takeya; Miki, Tokuhiko; Hayashi, Kazuhiko

doi:10.1016/s0002-9394(98)00153-6

Cited by 33 publications

(23 citation statements)

References 13 publications

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“…A study using indocyanine green angiography revealed a triangularshaped area of delayed filling of the choroidal arteries, delayed filling of the choroidal veins, intrachoroidal indocyanine green leakage, and/or changes in choroidal vasculature. 50 Another experimental study using horseradish peroxidase suggested that extracellular edema occurs in the early stages of commotio retinae because of the disruption of the outer blood-retinal barrier. 51 Hui and associates 52 established a rabbit model of severe retinal contusion injury.…”

Section: Commotio Retinaementioning

confidence: 99%

Posterior Segment Manifestations of Closed-Globe Contusion Injury

Win¹,

Ober²

2006

Retina

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Section: Commotio Retinaementioning

confidence: 99%

Posterior Segment Manifestations of Closed-Globe Contusion Injury

Win¹,

Ober²

2006

Retina

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“…However, cases due to severe injuries may develop permanent retinal degeneration following retinal opacity and have poor visual prognosis [5, 6]. Retinal degeneration is sometimes seen as a triangular shape at various sites of the fundus [7, 8]. Experimental studies of blunt trauma to the eye showed damage to photoreceptors and the retinal pigment epithelium (RPE), which regenerated during follow-up [9, 10].…”

Section: Introductionmentioning

confidence: 99%

“…This suggests that disruption to the choroidal circulation occurs following breakdown of the short posterior ciliary arteries and may play a role in the pathogenesis of outer retinal damage secondary to ocular blunt trauma. Moreover, in both animal and human studies, indocyanine green angiography (ICGA) showed a defect in choroidal inflow or spasm of the choroidal artery corresponding to the lesion site [8, 11]. Therefore, ICGA is a useful tool that can evaluate various choroidal circulation disturbances in patients with the ocular blunt trauma [8].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in both animal and human studies, indocyanine green angiography (ICGA) showed a defect in choroidal inflow or spasm of the choroidal artery corresponding to the lesion site [8, 11]. Therefore, ICGA is a useful tool that can evaluate various choroidal circulation disturbances in patients with the ocular blunt trauma [8]. However, choroidal circulation hemodynamics in chorioretinopathy with ocular blunt trauma has not been examined quantitatively, because ICGA is a qualitative examination.…”

Section: Introductionmentioning

confidence: 99%

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Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma

et al. 2017

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Background: Choroidal circulation hemodynamics in eyes with ocular blunt trauma has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and thickness at the lesion site using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with chorioretinopathy associated with ocular blunt trauma. Case presentation: A 13-year-old boy developed a chorioretinal lesion with pigmentation extending from the optic disc to the superotemporal side in the right eye after ocular blunt trauma. The patient's best-corrected visual acuity (BCVA) was 0.2 in the right eye. Indocyanine green angiography showed hypofluorescence from the initial phase, with a decrease of mean blur rate (MBR) on LSFG color map, which corresponded to the chorioretinal lesion. The BCVA and foveal outer retinal morphologic abnormality spontaneously improved during follow-up. MBR and choroidal thickness increased by 23-31% and 13-17 μm at the lesion site and by 11-22% and 33-42 μm at the fovea, respectively, during the 6-month follow-up period after baseline measurements in the affected eye. In contrast, these parameters showed little or no changes at the normal retinal site in the affected eye and the fovea in the fellow eye. Conclusions: Current data revealed that both blood flow velocity and thickness in the choroid at the lesion site decreased in the acute stage and subsequently increased together with improvements in visual function and outer retinal morphology. These results suggest that LSFG and EDI-OCT may be useful indices that can noninvasively evaluate activity of choroidal involvement in ocular blunt trauma-associated chorioretinopathy.

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“…Owing to intense fluorescence, they are very efficient sensitizers in photography, biological stains, redox indicators, laser dyes [9] and fluorescence probes [10]. Compounds of this class have attracted attentions from medicinal chemists and clinicians because of their exhibit biological activities [11][12][13]. Four fluorescent dyes with planar aromatic ring systems were selected in this paper ( Fig.…”

Section: Introductionmentioning

confidence: 99%