Choroidal thickness following extrafoveal photodynamic treatment with verteporfin in patients with central serous chorioretinopathy

Abstract

ABSTRACT.Purpose: To evaluate the effect of verteporfin photodynamic treatment (PDT) on choroidal thickness in patients with central serous chorioretinopathy (CSC). Methods: Choroidal thickness was measured with enhanced depth imaging-optical coherence tomography (EDI-OCT) before and after verteporfin PDT (fulldose verteporfin, half-light dose) in 16 eyes in 16 patients with serous detachment of the fovea secondary to extrafoveal angiographic fluorescein leakage. Treatment was confined to the area of leakage, whereas choroidal thickness before and after treatment was assessed over a larger area of the fundus using OCT. Results: Complete resolution of the serous detachment was seen in all 16 eyes within 1 month of extrafoveal PDT, while choroidal thickness in the area where PDT was applied decreased from 407 lm [mean; 95% confidence interval (CI 95 ) 356-458 lm] to 349 lm (mean; CI 95 300-399 lm; p < 0.0001), and subfoveal choroidal thickness was reduced from 421 lm (mean; CI 95 352-489 lm) to 346 lm (mean; CI 95 278-414 lm; p = 0.0001). Initially, subfoveal choroidal thickness was significantly increased in the treated eye compared with the healthy fellow eye (mean 324 lm; CI 95 273-376 lm; p = 0.0003), but after treatment, the difference was not significant. Discussion: Photodynamic therapy of active CSC was followed by choroidal thickness reduction, not only locally but also at considerable distance from the treated area. Thus, the process that causes choroidal thickening in CSC appears to spread laterally within the choroid.

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity

“…They suggested 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) as a key mediator that might cause choroidal vaso-obliteration, thereby affecting CT through the induction of oxidant stress in ROP [3]. In addition, the application of laser treatment to the eyes could affect choroidal circulation [29]. In agreement with this finding, we observed a positive correlation of central CT and BCVA in children with a history of ROP.…”

Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy

“…Pryds and Larsen 29 reported that the reduction of choroidal thickness occurred not only inside the PDTapplied area but also outside the PDT-applied area after a half-light dose PDT for chronic CSC. In this study, choroidal thickness and the cross-sectional area of the large choroidal vein significantly decreased both inside and outside the PDT-applied area after 1/2 PDT.…”

Efficacy of 1/3-Dose Verteporfin Photodynamic Therapy for Subacute Central Serous Chorioretinopathy

“…Previous studies have shown that the choroidal thickness rapidly decreased after successful PDT and that it remained decreased for years [8] [26] [27] [28]. The previous study reported that choroidal thickness decreased by 4.1 μm for every year increase in age [29].…”